ES8608685A1 - Procedimiento de preparar anticuerpos monoclonales y metodo de preparar reactivos para detectar canceres - Google Patents
Procedimiento de preparar anticuerpos monoclonales y metodo de preparar reactivos para detectar canceresInfo
- Publication number
- ES8608685A1 ES8608685A1 ES546696A ES546696A ES8608685A1 ES 8608685 A1 ES8608685 A1 ES 8608685A1 ES 546696 A ES546696 A ES 546696A ES 546696 A ES546696 A ES 546696A ES 8608685 A1 ES8608685 A1 ES 8608685A1
- Authority
- ES
- Spain
- Prior art keywords
- monoclonal antibody
- cancer
- reagent
- preparing same
- associated antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 201000011510 cancer Diseases 0.000 title abstract 5
- 239000000427 antigen Substances 0.000 title abstract 4
- 102000036639 antigens Human genes 0.000 title abstract 4
- 108091007433 antigens Proteins 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 3
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 abstract 2
- 102100032412 Basigin Human genes 0.000 abstract 1
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 101000798441 Homo sapiens Basigin Proteins 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- HFZNPKDYLSOGBE-SCEMAYBHSA-N nrc-12 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(C)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C1=CC=C(O)C=C1 HFZNPKDYLSOGBE-SCEMAYBHSA-N 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000009257 reactivity Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
METODO DE PREPARACION DE ANTICUERPOS MONOCLONALES, DOTADOS DE ESPECIFICIDAD DE UNION PARA ANTIGENOS ASOCIADOS CON EL CANCER DE PANCREAS, CON EL CANCER DE INTESTINO GRUESO Y CON EL HEPATOMA, QUE TIENEN APLICACIONES COMO REACTIVOS PARA DETECTAR DICHOS CANCERES. CONSISTE EN LA FUSION DE UNA CELULA FORMADORA DE ANTICUERPO CON UNA CELULA DE MIELOMA PARA FORMAR CELULAS DE HIBRIDOMA, CLONACION DE ESTAS PARA OBTENER CLONES QUE PRODUCEN ANTICUERPOS QUE TIENEN ESPECIFIDAD DE UNION CON LOS ANTIGENOS ASOCIADOS CON EL CANCER DE PANCREAS, CON EL CANCER DE INTESTINO GRUESO Y CON HEPATOMA; SEGUIDA DEL CULTIVO DEL CLON PARA PRODUCIR UN ANTICUERPO MONOCLONAL, Y RECOGER EL ANTICUERPO CON EL QUE SE SENSIBILIZAN CELULAS SANGUINEAS O UN LATEX.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59166980A JPS6144900A (ja) | 1984-08-08 | 1984-08-08 | モノクロ−ナル抗体及び癌抗原検出用試薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES546696A0 ES546696A0 (es) | 1986-07-16 |
| ES8608685A1 true ES8608685A1 (es) | 1986-07-16 |
Family
ID=15841169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES546696A Expired ES8608685A1 (es) | 1984-08-08 | 1985-08-08 | Procedimiento de preparar anticuerpos monoclonales y metodo de preparar reactivos para detectar canceres |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4959320A (es) |
| EP (1) | EP0171083B1 (es) |
| JP (1) | JPS6144900A (es) |
| KR (1) | KR860001593A (es) |
| CA (1) | CA1309039C (es) |
| DE (1) | DE3580538D1 (es) |
| ES (1) | ES8608685A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4701408A (en) * | 1984-01-30 | 1987-10-20 | Smithkline Beckman Corporation | Monoclonal antibody to activated macrophages |
| JPH0623763B2 (ja) * | 1985-02-15 | 1994-03-30 | 日清製粉株式会社 | モノクローナル抗体を含む肝疾患診断剤 |
| US4916055A (en) * | 1985-12-13 | 1990-04-10 | Baylor College Of Medicine | Detection of human cancer with a monoclonal antibody specific for antigen gp650 |
| JPH0673470B2 (ja) * | 1986-07-15 | 1994-09-21 | 協和醗酵工業株式会社 | 抗ヒト胃癌単クロ−ン性抗体ａｍｃ−４６２ |
| JPS6357596A (ja) * | 1986-08-29 | 1988-03-12 | Nisshin Flour Milling Co Ltd | モノクロ−ナル抗体、その製法およびそれからなる肝疾患診断剤 |
| EP0259773A3 (en) * | 1986-09-10 | 1990-05-30 | Asahi Kasei Kogyo Kabushiki Kaisha | A novel antibody specific for a cancer antigen |
| US4857452A (en) * | 1986-12-04 | 1989-08-15 | E. I. Du Pont De Nemours And Company | Assay for carcinoma of breast, colon and ovary |
| JPH0798000B2 (ja) * | 1987-05-23 | 1995-10-25 | 萩原 義秀 | ガン関連抗原特異的ヒト免疫グロブリン |
| DE3909799A1 (de) | 1989-03-24 | 1990-09-27 | Behringwerke Ag | Monoklonale antikoerper (mak) gegen tumorassoziierte antigene, ihre herstellung und verwendung |
| JPH06113831A (ja) * | 1992-04-08 | 1994-04-26 | Dev Center For Biotechnol | ハイブリドーマおよびその抗体 |
| US6225049B1 (en) | 1992-06-17 | 2001-05-01 | The United States Of America As Represented By The Department Of Health And Human Services | Human insulinoma-associated cDNA |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4471057A (en) * | 1981-06-30 | 1984-09-11 | The Wistar Institute | Detection of colorectal carcinoma |
| JPS59205327A (ja) * | 1983-03-11 | 1984-11-20 | スロ−ン−ケツタリング・インステイテユ−ト・フオ−・キヤンサ−・リサ−チ | ヒト膀胱及び尿管がんに対するモノクロ−ナル抗体及び方法 |
| US4683200A (en) * | 1984-05-17 | 1987-07-28 | Setsuo Hirohashi | Monoclonal antibody to human cancer antigen and method for producing same |
-
1984
- 1984-08-08 JP JP59166980A patent/JPS6144900A/ja active Granted
-
1985
- 1985-08-08 EP EP85110006A patent/EP0171083B1/en not_active Expired - Lifetime
- 1985-08-08 KR KR1019850005719A patent/KR860001593A/ko not_active Application Discontinuation
- 1985-08-08 ES ES546696A patent/ES8608685A1/es not_active Expired
- 1985-08-08 DE DE8585110006T patent/DE3580538D1/de not_active Expired - Lifetime
- 1985-08-08 CA CA000488311A patent/CA1309039C/en not_active Expired - Lifetime
- 1985-08-08 US US06/763,587 patent/US4959320A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4959320A (en) | 1990-09-25 |
| EP0171083A2 (en) | 1986-02-12 |
| JPH0429358B2 (es) | 1992-05-18 |
| DE3580538D1 (de) | 1990-12-20 |
| ES546696A0 (es) | 1986-07-16 |
| EP0171083A3 (en) | 1987-12-02 |
| CA1309039C (en) | 1992-10-20 |
| EP0171083B1 (en) | 1990-11-14 |
| KR860001593A (ko) | 1986-03-20 |
| JPS6144900A (ja) | 1986-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970203 |