ES8608542A1 - Un metodo para producir una composicion de gamma-interferon de ser humano. - Google Patents

Un metodo para producir una composicion de gamma-interferon de ser humano.

Info

Publication number
ES8608542A1
ES8608542A1 ES544991A ES544991A ES8608542A1 ES 8608542 A1 ES8608542 A1 ES 8608542A1 ES 544991 A ES544991 A ES 544991A ES 544991 A ES544991 A ES 544991A ES 8608542 A1 ES8608542 A1 ES 8608542A1
Authority
ES
Spain
Prior art keywords
composition
interferon
gamma
stable composition
reconstitution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544991A
Other languages
English (en)
Other versions
ES544991A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1984/000352 external-priority patent/WO1986000531A1/ja
Priority claimed from PCT/JP1985/000190 external-priority patent/WO1986006080A1/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES544991A0 publication Critical patent/ES544991A0/es
Publication of ES8608542A1 publication Critical patent/ES8608542A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

METODO DE PREPARACION DE COMPOSICIONES DE GAMMA-INTERFERON DE SER HUMANO CONGELADAS O LIOFILIZADAS EN AUSENCIA DE SALES INORGANICAS Y EN PRESENCIA DE AMINOACIDOS. CONSISTE EN LA ADICION DE UN AMINOACIDO MONOAMINO-ALIFATICO, NEUTRO O ACIDO, A UNA DISOLUCION ACUOSA SUSTANCIALMENTE LIBRE DE SALES INORGANICAS QUE CONTIENE GAMMA-INTERFERON HUMANO RECOMBINANTE ALTAMENTE CONCENTRADA; AJUSTAR EL PH DE LA COMPOSICION A UN VALOR ENTRE 4,0 Y 5,0 SI EL AMINOACIDO ES NEUTRO, O A UN VALOR ENTRE 7,5 Y 8,5 SI EL AMINOACIDO ES ACIDO; CONGELAR LA DISOLUCION RESULTANTE Y, EVENTUALMENTE, SECAR LA COMPOSICION CONGELADA A PRESION REDUCIDA SI SE DESEA OBTENER LA COMPOSICION LIOFILIZADA. ESTAS COMPOSICIONES TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIVIRAL Y ANTITUMORAL.
ES544991A 1984-07-10 1985-07-09 Un metodo para producir una composicion de gamma-interferon de ser humano. Expired ES8608542A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP1984/000352 WO1986000531A1 (en) 1984-07-10 1984-07-10 Gamma-interferon composition
PCT/JP1985/000190 WO1986006080A1 (fr) 1985-04-12 1985-04-12 COMPOSITION D'INTERFERON-gamma

Publications (2)

Publication Number Publication Date
ES544991A0 ES544991A0 (es) 1986-06-16
ES8608542A1 true ES8608542A1 (es) 1986-06-16

Family

ID=26425053

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544991A Expired ES8608542A1 (es) 1984-07-10 1985-07-09 Un metodo para producir una composicion de gamma-interferon de ser humano.

Country Status (2)

Country Link
EP (1) EP0168008A3 (es)
ES (1) ES8608542A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150067A3 (en) * 1984-01-23 1986-12-30 Takeda Chemical Industries, Ltd. Stable composition of gamma-interferon
JPS60243028A (ja) * 1984-04-28 1985-12-03 Kyowa Hakko Kogyo Co Ltd インタ−フエロンの可溶化方法
NO861139L (no) * 1985-03-25 1986-09-26 Schering Corp Stabilt gamma-interferonpreparat.
US5183746A (en) * 1986-10-27 1993-02-02 Schering Aktiengesellschaft Formulation processes for pharmaceutical compositions of recombinant β-
US4895716A (en) * 1987-06-09 1990-01-23 Biogen, Inc. Stabilized formulations of gamma interferons
US5004605A (en) * 1987-12-10 1991-04-02 Cetus Corporation Low pH pharmaceutical compositions of recombinant β-interferon
US5078997A (en) * 1988-07-13 1992-01-07 Cetus Corporation Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers
BG52073B2 (en) * 1990-01-24 1996-04-30 Inst Molekuljarna Biolog Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
KR100652943B1 (ko) 1998-06-26 2006-12-01 오츠카 세이야쿠 가부시키가이샤 수용성 건조 조성물
EG24184A (en) 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
CA2501690C (en) * 2002-10-08 2012-04-03 Frank H. Gaertner Amended recombinant cells (arcs) for the production and delivery of antiviral agents, adjuvants and vaccine accelerants

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5821691A (ja) * 1981-07-29 1983-02-08 Mochida Pharmaceut Co Ltd α−及びβ−インタ−フェロンの精製方法
EP0082481B2 (en) * 1981-12-23 1990-09-12 Schering Corporation Stabilised alpha-interferon formulations and their preparation
JPS59181224A (ja) * 1983-03-29 1984-10-15 Sumitomo Chem Co Ltd 安定なインタ−フエロン製剤の製法
EP0150067A3 (en) * 1984-01-23 1986-12-30 Takeda Chemical Industries, Ltd. Stable composition of gamma-interferon
JPS60243028A (ja) * 1984-04-28 1985-12-03 Kyowa Hakko Kogyo Co Ltd インタ−フエロンの可溶化方法

Also Published As

Publication number Publication date
EP0168008A3 (en) 1986-12-30
ES544991A0 (es) 1986-06-16
EP0168008A2 (en) 1986-01-15

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