ES8607223A1 - Procedimiento para la obtencion de un aducto bisulfiticio demenadionacolina - Google Patents

Procedimiento para la obtencion de un aducto bisulfiticio demenadionacolina

Info

Publication number
ES8607223A1
ES8607223A1 ES549335A ES549335A ES8607223A1 ES 8607223 A1 ES8607223 A1 ES 8607223A1 ES 549335 A ES549335 A ES 549335A ES 549335 A ES549335 A ES 549335A ES 8607223 A1 ES8607223 A1 ES 8607223A1
Authority
ES
Spain
Prior art keywords
preparation
bisulfite adduct
menadioncholine
menadione
adduct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549335A
Other languages
English (en)
Other versions
ES549335A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of ES549335A0 publication Critical patent/ES549335A0/es
Publication of ES8607223A1 publication Critical patent/ES8607223A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN ADUCTO BISULFITICIO DE MENADIONA-COLINA. COMPRENDE A) TRATAR A UNA SOLUCION DE BICARBONATO DE COLINA ACUOSA CONCENTRADA CON DIOXIDO DE AZUFRE LIQUIDO O GASEOSO A UN PH ENTRE 4 Y 5, PARA OBTENER BISULFITO DE COLINA DE FORMULA (II); B) HACER REACCIONAR AL BISULFITO DE COLINA DE FORMULA (II) CON LA MENADIONA FINAMENTE PULVERIZADA DE FORMULA (III), A UNA TEMPERATURA ENTRE 0J Y 80JC, PARA OBTENER UN ADUCTO BISULFITICO DE MENADIONA-COLINA DE FORMULA (I) SOLUBLE EN AGUA; C) AGREGAR UN DISOLVENTE MISCIBLE EN AGUA, COMO ALCOHOL DE C 3 O TETRAHIDROFURANO A LA SOLUCION DE (B) PARA CRISTALIZAR A (I); D) FILTRAR LA SOLUCION PARA SEPARAR LOS CRISTALES; Y E) SECAR A LOS CRISTALES. SE UTILIZAN COMO ANTIHEMORRAGICOS.
ES549335A 1984-11-28 1985-11-27 Procedimiento para la obtencion de un aducto bisulfiticio demenadionacolina Expired ES8607223A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843443270 DE3443270A1 (de) 1984-11-28 1984-11-28 Menadioncholinbisulfit-addukt und verfahren zu dessen herstellung

Publications (2)

Publication Number Publication Date
ES549335A0 ES549335A0 (es) 1986-05-16
ES8607223A1 true ES8607223A1 (es) 1986-05-16

Family

ID=6251307

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549335A Expired ES8607223A1 (es) 1984-11-28 1985-11-27 Procedimiento para la obtencion de un aducto bisulfiticio demenadionacolina

Country Status (6)

Country Link
US (1) US4735969A (es)
EP (1) EP0183194B1 (es)
JP (1) JPH0670000B2 (es)
DE (2) DE3443270A1 (es)
ES (1) ES8607223A1 (es)
IL (1) IL77141A (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3700812A1 (de) * 1987-01-14 1988-07-28 Basf Ag Stabilisierte menadionbisulfit-formulierungen und verfahren zu deren herstellung
WO1989011268A1 (en) * 1988-05-26 1989-11-30 Vsesojuzny Nauchno-Issledovatelsky I Ispytatelny I Injection-type hemostatic composition
EP2281465A1 (en) * 2009-08-05 2011-02-09 Lonza Ltd. Vitamin K3 derivative / NSA formulation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2295129A (en) * 1939-12-22 1942-09-08 Abbott Lab Process of preparing vitamin k concentrates
US2331808A (en) * 1941-05-01 1943-10-12 Wm S Merrell Co Composition of matter
CH260991A (de) * 1944-12-29 1949-04-15 Abbott Lab Verfahren zur Herstellung eines festen pharmazeutischen Präparates mit antihämorrhagischen Eigenschaften.
FR996080A (fr) * 1945-04-20 1951-12-12 Francolor Sa Procédé de préparation d'un dérivé soluble dans l'eau de la méthyl-2-naphtoquinone-1-4
US2827377A (en) * 1953-09-02 1958-03-18 Abbott Lab Animal feed composition
GB771180A (en) * 1954-09-16 1957-03-27 Abbott Lab 1,4-naphthoquinone addition product
DE1033017B (de) * 1955-03-14 1958-06-26 Abbott Lab Futtermittelmischung
NL143128B (nl) * 1962-11-09 1974-09-16 Randstad Chem Ind Werkwijze voor het bereiden van een zout van een organische base en menadionbisulfiet, alsmede werkwijze ter bereiding van een veterinair preparaat onder toepassing van een aldus bereid zout.
US3947491A (en) * 1972-03-24 1976-03-30 The Purdue Frederick Company Stabilized choline salicylate compounds
IT1097391B (it) * 1978-07-21 1985-08-31 Stoppani Luigi Spa Addotti di composti vitaminici del tipo k e vitamine stabilizzanti,loro preparazione e addotti stabilizzati cosi' ottenuti

Also Published As

Publication number Publication date
EP0183194A3 (en) 1986-07-30
ES549335A0 (es) 1986-05-16
JPS61143345A (ja) 1986-07-01
IL77141A0 (en) 1986-04-29
DE3560791D1 (en) 1987-11-26
EP0183194B1 (de) 1987-10-21
IL77141A (en) 1989-10-31
DE3443270A1 (de) 1986-05-28
JPH0670000B2 (ja) 1994-09-07
US4735969A (en) 1988-04-05
EP0183194A2 (de) 1986-06-04

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100623