ES8606886A1 - Un procedimiento para producir interferon inmune humano recombinante intacto - Google Patents
Un procedimiento para producir interferon inmune humano recombinante intactoInfo
- Publication number
- ES8606886A1 ES8606886A1 ES536028A ES536028A ES8606886A1 ES 8606886 A1 ES8606886 A1 ES 8606886A1 ES 536028 A ES536028 A ES 536028A ES 536028 A ES536028 A ES 536028A ES 8606886 A1 ES8606886 A1 ES 8606886A1
- Authority
- ES
- Spain
- Prior art keywords
- purification
- immune interferon
- interferon
- extraction
- human immune
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
METODO DE PRODUCCION DE INTERFERON INMUNE HUMANO RECOMBINANTE INTACTO QUE TIENE LA SECUENCIA DE AMINOACIDO (I), CON UN RESODUO OPCIONAL DE METIONINA ADICIONAL EN EL AMINO TERMICO, LIBRE DE SUS FRAGMENTOS PROTEOLITICOS DE MICROORGANISMOS TRANSFORMADOS CONTENIDOS EN DICHA PROTEINA. COMPRENDE LA EXTRACCION EN LA TERMINAL AMINO, HUMANO RECOMBINANTE INTACTO DE MICROORGANISMOS TRANSFORMADOS, SUSPENDIDOS EN UNA DISOLUCION DE GUANIDINA-HCL CON UN INHIBIDOR DE PROTEASA, TAL COMO UNA SAL DE GUANIDINA Y PURIFICACION DEL INTERFERON EXTRAIDO RESULTANTE, MEDIANTE ANTICUERPOS MONOCLONALES. ESTE INTERFERON TIENE APLICACIONES PARA LA PROFILAXIS O TRATAMIENTO DE TRASTORNOS VIRALES O NEOPLASTICOS O EN EL TRATAMIENTO DE CONDICIONES INMUNOSUPRESIVAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53404083A | 1983-09-20 | 1983-09-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8606886A1 true ES8606886A1 (es) | 1986-05-16 |
ES536028A0 ES536028A0 (es) | 1986-05-16 |
Family
ID=24128473
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES536028A Expired ES8606886A1 (es) | 1983-09-20 | 1984-09-19 | Un procedimiento para producir interferon inmune humano recombinante intacto |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0138087B1 (es) |
JP (1) | JP2592441B2 (es) |
KR (1) | KR940004544B1 (es) |
AT (1) | ATE33842T1 (es) |
AU (1) | AU590712B2 (es) |
DE (1) | DE3470747D1 (es) |
DK (1) | DK162604C (es) |
ES (1) | ES8606886A1 (es) |
FI (1) | FI80293C (es) |
GB (1) | GB2146998B (es) |
GR (1) | GR80405B (es) |
HU (1) | HU196461B (es) |
IL (1) | IL72986A (es) |
MC (1) | MC1627A1 (es) |
NO (1) | NO161274C (es) |
NZ (1) | NZ209588A (es) |
PH (1) | PH23241A (es) |
PT (1) | PT79232B (es) |
ZA (1) | ZA846554B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2164650A (en) * | 1984-09-25 | 1986-03-26 | Fujisawa Pharmaceutical Co | Process for production of y-interferon |
GB8508340D0 (en) * | 1985-03-29 | 1985-05-09 | Creighton T E | Production of protein |
DE19755960C1 (de) | 1997-12-16 | 1998-11-26 | Hoechst Ag | Verfahren zum Aufschluß von biologischem Material |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7404589A (nl) * | 1974-04-03 | 1975-10-07 | Stichting Rega V Z W | Werkwijze voor het stabiliseren van interferon. |
DE3005897A1 (de) * | 1980-02-16 | 1981-09-03 | Hoechst Ag, 6000 Frankfurt | Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus |
IL65475A0 (en) * | 1981-04-17 | 1982-07-30 | Meloy Lab | Production of immune interferon and its mrna |
IL63327A (en) * | 1981-07-16 | 1985-11-29 | Yeda Res & Dev | Production of interferon beta1 and alpha-phage recombinants for its production in host bacteria |
AU561343B2 (en) * | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
JPS58110548A (ja) * | 1981-12-24 | 1983-07-01 | Asahi Chem Ind Co Ltd | 新規な生理活性ペプチド |
EP0088540A3 (en) * | 1982-02-22 | 1984-10-17 | Biogen, Inc. | Dna sequences, recombinant dna molecules and processes for producing human immune interferon-like polypeptides |
IL68100A0 (en) * | 1982-03-24 | 1983-06-15 | Takeda Chemical Industries Ltd | Novel dna and use thereof |
IL69851A0 (en) * | 1982-09-30 | 1983-12-30 | Japan Found Cancer | Novel dna and recombinant plasmid containing the same |
WO1984002129A1 (en) * | 1982-11-22 | 1984-06-07 | Takeda Chemical Industries Ltd | Human immune interferon protein and process for its preparation |
JPH0740925B2 (ja) * | 1983-03-14 | 1995-05-10 | 協和醗酵工業株式会社 | 新規ヒトインタ−フエロン−γポリペプチド |
US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
-
1984
- 1984-08-22 ZA ZA846554A patent/ZA846554B/xx unknown
- 1984-09-18 NZ NZ209588A patent/NZ209588A/xx unknown
- 1984-09-18 EP EP19840111130 patent/EP0138087B1/en not_active Expired
- 1984-09-18 GR GR80405A patent/GR80405B/el unknown
- 1984-09-18 AT AT84111130T patent/ATE33842T1/de not_active IP Right Cessation
- 1984-09-18 DE DE8484111130T patent/DE3470747D1/de not_active Expired
- 1984-09-18 IL IL72986A patent/IL72986A/xx not_active IP Right Cessation
- 1984-09-19 KR KR84005714A patent/KR940004544B1/ko not_active IP Right Cessation
- 1984-09-19 MC MC841728A patent/MC1627A1/xx unknown
- 1984-09-19 NO NO843750A patent/NO161274C/no unknown
- 1984-09-19 PT PT79232A patent/PT79232B/pt not_active IP Right Cessation
- 1984-09-19 GB GB08423748A patent/GB2146998B/en not_active Expired
- 1984-09-19 JP JP59196499A patent/JP2592441B2/ja not_active Expired - Lifetime
- 1984-09-19 ES ES536028A patent/ES8606886A1/es not_active Expired
- 1984-09-19 PH PH31245A patent/PH23241A/en unknown
- 1984-09-19 AU AU33301/84A patent/AU590712B2/en not_active Ceased
- 1984-09-19 HU HU843509A patent/HU196461B/hu not_active IP Right Cessation
- 1984-09-19 FI FI843669A patent/FI80293C/fi not_active IP Right Cessation
- 1984-09-19 DK DK447784A patent/DK162604C/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GB2146998B (en) | 1987-10-07 |
GR80405B (en) | 1985-01-21 |
FI80293C (fi) | 1990-05-10 |
AU3330184A (en) | 1985-03-28 |
EP0138087A1 (en) | 1985-04-24 |
DK162604C (da) | 1992-05-11 |
DK162604B (da) | 1991-11-18 |
HU196461B (en) | 1988-11-28 |
NO161274B (no) | 1989-04-17 |
JPS6169800A (ja) | 1986-04-10 |
PH23241A (en) | 1989-06-06 |
GB2146998A (en) | 1985-05-01 |
KR850002285A (ko) | 1985-05-10 |
HUT35289A (en) | 1985-06-28 |
FI843669L (fi) | 1985-03-21 |
IL72986A (en) | 1990-04-29 |
FI843669A0 (fi) | 1984-09-19 |
PT79232A (en) | 1984-10-01 |
KR940004544B1 (en) | 1994-05-25 |
DK447784D0 (da) | 1984-09-19 |
DK447784A (da) | 1985-03-21 |
PT79232B (en) | 1986-11-18 |
NO161274C (no) | 1989-07-26 |
JP2592441B2 (ja) | 1997-03-19 |
AU590712B2 (en) | 1989-11-16 |
NO843750L (no) | 1985-03-21 |
DE3470747D1 (en) | 1988-06-01 |
MC1627A1 (fr) | 1985-09-26 |
ZA846554B (en) | 1985-04-24 |
IL72986A0 (en) | 1984-12-31 |
EP0138087B1 (en) | 1988-04-27 |
NZ209588A (en) | 1989-05-29 |
ATE33842T1 (de) | 1988-05-15 |
FI80293B (fi) | 1990-01-31 |
ES536028A0 (es) | 1986-05-16 |
GB8423748D0 (en) | 1984-10-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ209589A (en) | Method of extracting human immune interferon from transformed microorganisms in the precence of a protease inhibitor | |
PT76360B (en) | Expression processing and secretion of heterologus protein by yeast | |
AU577314B2 (en) | Human y interferon fragment and production from recombinant microbes | |
MY101457A (en) | Toxins and antibodies of c.difficile. | |
ES8606886A1 (es) | Un procedimiento para producir interferon inmune humano recombinante intacto |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20001009 |