ES8606886A1 - Un procedimiento para producir interferon inmune humano recombinante intacto - Google Patents

Un procedimiento para producir interferon inmune humano recombinante intacto

Info

Publication number
ES8606886A1
ES8606886A1 ES536028A ES536028A ES8606886A1 ES 8606886 A1 ES8606886 A1 ES 8606886A1 ES 536028 A ES536028 A ES 536028A ES 536028 A ES536028 A ES 536028A ES 8606886 A1 ES8606886 A1 ES 8606886A1
Authority
ES
Spain
Prior art keywords
purification
immune interferon
interferon
extraction
human immune
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536028A
Other languages
English (en)
Other versions
ES536028A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24128473&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8606886(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8606886A1 publication Critical patent/ES8606886A1/es
Publication of ES536028A0 publication Critical patent/ES536028A0/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/57IFN-gamma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

METODO DE PRODUCCION DE INTERFERON INMUNE HUMANO RECOMBINANTE INTACTO QUE TIENE LA SECUENCIA DE AMINOACIDO (I), CON UN RESODUO OPCIONAL DE METIONINA ADICIONAL EN EL AMINO TERMICO, LIBRE DE SUS FRAGMENTOS PROTEOLITICOS DE MICROORGANISMOS TRANSFORMADOS CONTENIDOS EN DICHA PROTEINA. COMPRENDE LA EXTRACCION EN LA TERMINAL AMINO, HUMANO RECOMBINANTE INTACTO DE MICROORGANISMOS TRANSFORMADOS, SUSPENDIDOS EN UNA DISOLUCION DE GUANIDINA-HCL CON UN INHIBIDOR DE PROTEASA, TAL COMO UNA SAL DE GUANIDINA Y PURIFICACION DEL INTERFERON EXTRAIDO RESULTANTE, MEDIANTE ANTICUERPOS MONOCLONALES. ESTE INTERFERON TIENE APLICACIONES PARA LA PROFILAXIS O TRATAMIENTO DE TRASTORNOS VIRALES O NEOPLASTICOS O EN EL TRATAMIENTO DE CONDICIONES INMUNOSUPRESIVAS.
ES536028A 1983-09-20 1984-09-19 Un procedimiento para producir interferon inmune humano recombinante intacto Expired ES8606886A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53404083A 1983-09-20 1983-09-20

Publications (2)

Publication Number Publication Date
ES8606886A1 true ES8606886A1 (es) 1986-05-16
ES536028A0 ES536028A0 (es) 1986-05-16

Family

ID=24128473

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536028A Expired ES8606886A1 (es) 1983-09-20 1984-09-19 Un procedimiento para producir interferon inmune humano recombinante intacto

Country Status (19)

Country Link
EP (1) EP0138087B1 (es)
JP (1) JP2592441B2 (es)
KR (1) KR940004544B1 (es)
AT (1) ATE33842T1 (es)
AU (1) AU590712B2 (es)
DE (1) DE3470747D1 (es)
DK (1) DK162604C (es)
ES (1) ES8606886A1 (es)
FI (1) FI80293C (es)
GB (1) GB2146998B (es)
GR (1) GR80405B (es)
HU (1) HU196461B (es)
IL (1) IL72986A (es)
MC (1) MC1627A1 (es)
NO (1) NO161274C (es)
NZ (1) NZ209588A (es)
PH (1) PH23241A (es)
PT (1) PT79232B (es)
ZA (1) ZA846554B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2164650A (en) * 1984-09-25 1986-03-26 Fujisawa Pharmaceutical Co Process for production of y-interferon
GB8508340D0 (en) * 1985-03-29 1985-05-09 Creighton T E Production of protein
DE19755960C1 (de) 1997-12-16 1998-11-26 Hoechst Ag Verfahren zum Aufschluß von biologischem Material

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7404589A (nl) * 1974-04-03 1975-10-07 Stichting Rega V Z W Werkwijze voor het stabiliseren van interferon.
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
IL65475A0 (en) * 1981-04-17 1982-07-30 Meloy Lab Production of immune interferon and its mrna
IL63327A (en) * 1981-07-16 1985-11-29 Yeda Res & Dev Production of interferon beta1 and alpha-phage recombinants for its production in host bacteria
AU561343B2 (en) * 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
EP0088540A3 (en) * 1982-02-22 1984-10-17 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing human immune interferon-like polypeptides
IL68100A0 (en) * 1982-03-24 1983-06-15 Takeda Chemical Industries Ltd Novel dna and use thereof
IL69851A0 (en) * 1982-09-30 1983-12-30 Japan Found Cancer Novel dna and recombinant plasmid containing the same
WO1984002129A1 (en) * 1982-11-22 1984-06-07 Takeda Chemical Industries Ltd Human immune interferon protein and process for its preparation
JPH0740925B2 (ja) * 1983-03-14 1995-05-10 協和醗酵工業株式会社 新規ヒトインタ−フエロン−γポリペプチド
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor

Also Published As

Publication number Publication date
GB2146998B (en) 1987-10-07
GR80405B (en) 1985-01-21
FI80293C (fi) 1990-05-10
AU3330184A (en) 1985-03-28
EP0138087A1 (en) 1985-04-24
DK162604C (da) 1992-05-11
DK162604B (da) 1991-11-18
HU196461B (en) 1988-11-28
NO161274B (no) 1989-04-17
JPS6169800A (ja) 1986-04-10
PH23241A (en) 1989-06-06
GB2146998A (en) 1985-05-01
KR850002285A (ko) 1985-05-10
HUT35289A (en) 1985-06-28
FI843669L (fi) 1985-03-21
IL72986A (en) 1990-04-29
FI843669A0 (fi) 1984-09-19
PT79232A (en) 1984-10-01
KR940004544B1 (en) 1994-05-25
DK447784D0 (da) 1984-09-19
DK447784A (da) 1985-03-21
PT79232B (en) 1986-11-18
NO161274C (no) 1989-07-26
JP2592441B2 (ja) 1997-03-19
AU590712B2 (en) 1989-11-16
NO843750L (no) 1985-03-21
DE3470747D1 (en) 1988-06-01
MC1627A1 (fr) 1985-09-26
ZA846554B (en) 1985-04-24
IL72986A0 (en) 1984-12-31
EP0138087B1 (en) 1988-04-27
NZ209588A (en) 1989-05-29
ATE33842T1 (de) 1988-05-15
FI80293B (fi) 1990-01-31
ES536028A0 (es) 1986-05-16
GB8423748D0 (en) 1984-10-24

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ES8606886A1 (es) Un procedimiento para producir interferon inmune humano recombinante intacto

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009