ES8606395A1 - Un metodo de preparar peptidos farmaceuticamente activos - Google Patents

Un metodo de preparar peptidos farmaceuticamente activos

Info

Publication number
ES8606395A1
ES8606395A1 ES532813A ES532813A ES8606395A1 ES 8606395 A1 ES8606395 A1 ES 8606395A1 ES 532813 A ES532813 A ES 532813A ES 532813 A ES532813 A ES 532813A ES 8606395 A1 ES8606395 A1 ES 8606395A1
Authority
ES
Spain
Prior art keywords
hydrogen
carbamyl
intermediates
preparation
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532813A
Other languages
English (en)
Other versions
ES532813A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES8606395A1 publication Critical patent/ES8606395A1/es
Publication of ES532813A0 publication Critical patent/ES532813A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE PREPARAR PEPTIDOS FARMACEUTICAMENTE ACTIVOS. COMPRENDE: A) HACER REACCIONAR UN REACTIVO DE FORMULA (II) CON OTRO REACTIVO DE FORMULA (III) ESTANDO LOS REACTIVOS (II) Y (III) OPCIONALMENTE PROTEGIDOS Y/O ACTIVADOS; B) DESPROTEGER EL PRODUCTO PARA OBTENER UN COMPUESTO DE FORMULA (I) O SUS SALES. SIENDO: R1 H, ALQUILO DE C 1 A 2, O UN GRUPO AMIDINO; R2 ES ALQUILO DE C 1 A 2; R3 ES H O CARBAMILO; X2 ES UN RADICAL D DE FORMULA (IV); Y1 ES UNA SECUENCIA RADICAL PARCIAL IDENTICA A LA SECUENCIA RADICAL PARCIAL N-TERMINAR DE LA FORMULA (I); Y2 ES IDENTICO AL RESTO DEL PRODUCTO PEPTIDO INCLUYENDO LA SECUENCIA RADICAL PARCIAL C-TERMINAL; Z1 Y Z2 SON H, HAL Y OTROS; M ES 2, 3 O 4; Y N ES 0, 1 O 2 CON LA CONDICION DE QUE CUANDO R3 ES CARBAMILO ENTONCES N ES SIEMPRE 1.
ES532813A 1983-05-26 1984-05-25 Un metodo de preparar peptidos farmaceuticamente activos Expired ES8606395A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838314646A GB8314646D0 (en) 1983-05-26 1983-05-26 Pharmaceutical amides

Publications (2)

Publication Number Publication Date
ES8606395A1 true ES8606395A1 (es) 1986-04-01
ES532813A0 ES532813A0 (es) 1986-04-01

Family

ID=10543432

Family Applications (2)

Application Number Title Priority Date Filing Date
ES532813A Expired ES8606395A1 (es) 1983-05-26 1984-05-25 Un metodo de preparar peptidos farmaceuticamente activos
ES545189A Expired ES8604991A1 (es) 1983-05-26 1985-07-15 Un metodo para preparar peptidos farmaceuticamente activos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES545189A Expired ES8604991A1 (es) 1983-05-26 1985-07-15 Un metodo para preparar peptidos farmaceuticamente activos

Country Status (17)

Country Link
US (1) US4540682A (es)
EP (1) EP0127154B1 (es)
JP (1) JPS59231053A (es)
KR (1) KR850000467A (es)
AT (1) ATE57188T1 (es)
AU (1) AU575324B2 (es)
CA (1) CA1251898A (es)
DE (1) DE3483338D1 (es)
DK (1) DK258884A (es)
ES (2) ES8606395A1 (es)
FI (1) FI82254C (es)
GB (1) GB8314646D0 (es)
GR (1) GR81890B (es)
HU (1) HU193569B (es)
IL (1) IL71932A (es)
NZ (1) NZ208283A (es)
ZA (1) ZA844004B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8622090D0 (en) * 1986-09-12 1986-10-22 Wellcome Found Pharmacologically active compounds
WO1994025482A1 (en) * 1993-04-23 1994-11-10 Evans Herbert J Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5965698A (en) * 1993-04-23 1999-10-12 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US5952465A (en) * 1993-04-23 1999-09-14 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5928896A (en) * 1993-04-23 1999-07-27 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US6258550B1 (en) 1993-04-23 2001-07-10 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US6084066A (en) * 1993-10-29 2000-07-04 Virginia Commonwealth University Polypetides that include conformation-constraining groups which flank a protein-protein interaction site
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6027890A (en) 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
DE69625620T2 (de) * 1996-08-23 2003-08-21 Sederma Sa Synthetische peptide und ihre verwendung in kosmetischen oder dermopharmazeutischen zusammensetzungen
US20100093643A1 (en) * 2006-08-17 2010-04-15 Irina Bobrova Cardioprotective compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4178371A (en) * 1977-12-15 1979-12-11 Reckitt & Colman Products Limited Tetrapeptide derivatives
US4288432A (en) * 1979-06-12 1981-09-08 Richter Gedeon Vegyeszeti Gyar Rt. Novel enkephalin analogs and process for the preparation thereof
US4265808A (en) * 1979-12-17 1981-05-05 Eli Lilly And Company Pharmacologically active peptides
US4322339A (en) * 1980-10-20 1982-03-30 Eli Lilly And Company Pharmacologically active peptides

Also Published As

Publication number Publication date
GB8314646D0 (en) 1983-06-29
CA1251898A (en) 1989-03-28
JPS59231053A (ja) 1984-12-25
EP0127154A3 (en) 1987-05-06
KR850000467A (ko) 1985-02-27
NZ208283A (en) 1988-07-28
AU575324B2 (en) 1988-07-28
FI842104A0 (fi) 1984-05-25
HU193569B (en) 1987-10-28
ATE57188T1 (de) 1990-10-15
ES545189A0 (es) 1986-03-01
DK258884A (da) 1984-11-27
GR81890B (es) 1984-12-12
IL71932A0 (en) 1984-09-30
FI82254B (fi) 1990-10-31
ES532813A0 (es) 1986-04-01
AU2870184A (en) 1984-11-29
HUT34764A (en) 1985-04-28
EP0127154A2 (en) 1984-12-05
US4540682A (en) 1985-09-10
DK258884D0 (da) 1984-05-25
ES8604991A1 (es) 1986-03-01
IL71932A (en) 1987-10-20
FI842104A (fi) 1984-11-27
ZA844004B (en) 1986-01-29
DE3483338D1 (de) 1990-11-08
EP0127154B1 (en) 1990-10-03
FI82254C (fi) 1991-02-11

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960401