ES8605689A1 - Un metodo mejoraddo de plasmaferesis - Google Patents

Un metodo mejoraddo de plasmaferesis

Info

Publication number
ES8605689A1
ES8605689A1 ES539188A ES539188A ES8605689A1 ES 8605689 A1 ES8605689 A1 ES 8605689A1 ES 539188 A ES539188 A ES 539188A ES 539188 A ES539188 A ES 539188A ES 8605689 A1 ES8605689 A1 ES 8605689A1
Authority
ES
Spain
Prior art keywords
module
conducting
fibers
plasma
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539188A
Other languages
English (en)
Other versions
ES539188A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES8605689A1 publication Critical patent/ES8605689A1/es
Publication of ES539188A0 publication Critical patent/ES539188A0/es
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
    • A61M1/3603—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
    • A61M1/3604—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in opposite directions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/247—Positive displacement blood pumps
    • A61M60/253—Positive displacement blood pumps including a displacement member directly acting on the blood
    • A61M60/268—Positive displacement blood pumps including a displacement member directly acting on the blood the displacement member being flexible, e.g. membranes, diaphragms or bladders
    • A61M60/279—Peristaltic pumps, e.g. roller pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
    • A61M60/37—Haemodialysis, haemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/424—Details relating to driving for positive displacement blood pumps
    • A61M60/438—Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being mechanical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/845—Constructional details other than related to driving of extracorporeal blood pumps
    • A61M60/851—Valves
    • A61M60/853—Valves the valve being formed by a flexible tube element which is clamped for restricting the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/147—Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/08—Prevention of membrane fouling or of concentration polarisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
    • A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20—By influencing the flow
    • B01D2321/2066—Pulsated flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20—By influencing the flow
    • B01D2321/2083—By reversing the flow

Abstract

PROCEDIMIENTO DE PLASMAFERESIS REALIZADO EN UN SISTEMA CON UNA PLURALIDAD DE FIBRAS HUECAS DE MEMBRANA POROSA, MOJABLES POR LA SANGRE, CON UN TAMAÑO DE PORO DE LA MEMBRANA SUSTANCIALMENTE UNIFORME Y CON EXTREMOS ABIERTOS DE ENTRADA Y EXTREMOS ABIERTOS DE SALIDA. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE CONDUCE LA SANGRE EN DIRECCION HACIA ADELANTE HASTA EL INTERIOR Y A TRAVES DE LAS FIBRAS, MIENTRAS SE MANTIENE UNA DIFERENCIA MEDIA POSITIVA DE PRESIONES A TRAVES DE LA MEMBRANA DESDE LAS ENTRADAS HASTA LAS SALIDAS; SEGUNDA, SE RECOGE LA SANGRE DEPLETADA EN PLASMA DE LAS SALIDAS DE LAS FIBRAS HUECAS; Y POR ULTIMO, SE RECOGE EL PLASMA QUE HA ATRAVESADO LOS POROS DE LAS MEMBRANAS.
ES539188A 1982-12-16 1984-12-28 Un metodo mejoraddo de plasmaferesis Expired ES8605689A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/450,221 US4668399A (en) 1982-02-16 1982-12-16 Hollow fiber plasmapheresis process

Publications (2)

Publication Number Publication Date
ES8605689A1 true ES8605689A1 (es) 1986-04-01
ES539188A0 ES539188A0 (es) 1986-04-01

Family

ID=23787248

Family Applications (2)

Application Number Title Priority Date Filing Date
ES528027A Granted ES528027A0 (es) 1982-12-16 1983-12-14 Un modulo de microfilamcion mejorado para separar sangre completa en una fraccion enriquecida celular y una fraccion enriquecida en plasma.
ES539188A Expired ES8605689A1 (es) 1982-12-16 1984-12-28 Un metodo mejoraddo de plasmaferesis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES528027A Granted ES528027A0 (es) 1982-12-16 1983-12-14 Un modulo de microfilamcion mejorado para separar sangre completa en una fraccion enriquecida celular y una fraccion enriquecida en plasma.

Country Status (15)

Country Link
US (1) US4668399A (es)
EP (1) EP0112173B1 (es)
JP (1) JPS59120162A (es)
AT (1) ATE45502T1 (es)
AU (1) AU570019B2 (es)
BR (1) BR8306936A (es)
CA (1) CA1258642A (es)
DE (1) DE3380399D1 (es)
DK (1) DK580083A (es)
ES (2) ES528027A0 (es)
GR (1) GR78782B (es)
IE (1) IE55079B1 (es)
IL (1) IL70456A (es)
MX (1) MX157826A (es)
ZA (1) ZA839291B (es)

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Publication number Priority date Publication date Assignee Title
DE3672898D1 (de) * 1985-05-27 1990-08-30 Asahi Medical Co Hydrophile poroese composite-membran, verfahren zu ihrer herstellung und ein plasma-separator.
EP0266683B1 (en) * 1986-10-29 1993-07-21 ASAHI MEDICAL Co., Ltd. A blood components collector unit
US4950224A (en) * 1988-08-05 1990-08-21 Healthdyne, Inc. Apparatus and method for in vivo plasma separation
US5008012A (en) * 1989-05-25 1991-04-16 Asahi Medical Co., Ltd. Compact plasma separator and an apparatus containing the same
US5017293A (en) * 1989-08-24 1991-05-21 Pfizer Hospital Products Group, Inc. Multi-pass blood washing and plasma removal device and method
DK119490D0 (da) * 1990-05-14 1990-05-14 Unes As Apparat til fremstilling af et koncentrat af koagulationsfaktorer, saasom fibrinogen, fra en blodportion
US5234608A (en) * 1990-12-11 1993-08-10 Baxter International Inc. Systems and methods for processing cellular rich suspensions
DK167517B1 (da) * 1991-11-11 1993-11-15 Squibb & Sons Inc Beholder til optagelse og adskillelse af en vaeske, fortrinsvis blodplasma, i dennes bestanddele
US5554293A (en) * 1993-06-28 1996-09-10 C. R. Bard, Inc. Disposable blood washing and apheresis device and method of using thereof
ZA948564B (en) * 1993-11-19 1995-07-26 Bristol Myers Squibb Co Liquid separation apparatus and method
ATE405335T1 (de) * 1994-12-02 2008-09-15 Vivolution As Methode und vorrichtung zum abtrennen von fibrinmonomer aus blutplasma
CZ164697A3 (cs) * 1994-12-02 1998-03-18 Bristol-Myers Sguibb Company Způsob oddělování složky z plazmy a zařízení k provádění tohoto způsobu
US5733446A (en) * 1994-12-02 1998-03-31 Bristol-Myers Squibb Company Centrifuge with annular filter
DE69929986T2 (de) * 1998-08-31 2006-10-19 Ambrus, Julian L. Verfahren zur entfernung von hiv und anderen viren aus blut
US7291122B2 (en) * 2000-03-24 2007-11-06 Immunocept, L.L.C. Hemofiltration methods for treatment of diseases in a mammal
ES2198216B1 (es) * 2002-07-02 2005-04-16 Juan Carlos Instituto Cientifico Y Tecnologico De Navarra, S.A.(67%). Medio de cultivo de celulas madre-progenitoras autologas humanas y sus aplicaciones.
WO2004014315A2 (en) * 2002-08-13 2004-02-19 Arbios Systems, Inc. Selective plasma exchange therapy
CA2516403C (en) 2003-01-17 2014-08-12 Aethlon Medical, Inc. Method for removal of viruses from blood by lectin affinity hemodialysis
US8142844B2 (en) * 2003-09-17 2012-03-27 Gambro Lundia Ab Separating material
US7740804B2 (en) * 2005-04-12 2010-06-22 Chromedx Inc. Spectroscopic sample holder
CA2517299A1 (en) * 2005-08-26 2007-02-26 Chromedx Inc. Hollow needle assembly
US20100245803A1 (en) * 2005-04-12 2010-09-30 Chromedx Inc. Blood sample holder for spectroscopic analysis
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
CA2507323A1 (en) * 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
US8747669B1 (en) 2005-12-29 2014-06-10 Spf Innovations, Llc Method and apparatus for the filtration of biological samples
US7384549B2 (en) 2005-12-29 2008-06-10 Spf Innovations, Llc Method and apparatus for the filtration of biological solutions
AU2011271943B2 (en) * 2010-06-28 2013-09-05 Kyowakiden Industry Co., Ltd. Hollow fiber forward osmosis membrane
JP2016533497A (ja) * 2013-07-09 2016-10-27 エスアールアイ インターナショナルＳＲＩ Ｉｎｔｅｒｎａｔｉｏｎａｌ 放射線傷害の線量評価のためのバイオマーカーパネルおよびマイクロ血漿フィルター
AU2019231885B2 (en) 2018-03-08 2022-03-24 Repligen Corporation Tangential flow depth filtration systems and methods of filtration using same
AU2019273030B2 (en) 2018-05-25 2022-08-18 Repligen Corporation Tangential flow filtration systems and methods

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US3342729A (en) * 1964-12-09 1967-09-19 Dow Chemical Co Permeability separatory cell and apparatus and method of using the same
GB1381410A (en) * 1971-12-10 1975-01-22 Kroyer K K K Process of diluting or concentrating a solution by osmosis dialysis or ultra-filtration and apparatus for carrying out said process
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US3853756A (en) * 1973-02-12 1974-12-10 Westinghouse Electric Corp Reverse pressure cleaning of supported semipermeable membranes
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US4247498A (en) * 1976-08-30 1981-01-27 Akzona Incorporated Methods for making microporous products
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JPS559227A (en) * 1978-06-30 1980-01-23 Fujitsu Ltd Character display system using gas discharge panel
JPS56110625A (en) * 1980-02-05 1981-09-01 Takeda Chem Ind Ltd Separating method of blood plasma and apparatus for the same
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US4343705A (en) * 1980-10-31 1982-08-10 Instrumentation Laboratory Biological liquid fractionation using alternate opposite flow directions across a membrane
DE3279765D1 (en) * 1981-07-22 1989-07-20 Du Pont Plasmapheresis by reciprocatory pulsatile filtration

Also Published As

Publication number Publication date
EP0112173B1 (en) 1989-08-16
EP0112173A3 (en) 1986-02-26
DK580083D0 (da) 1983-12-15
ES8600946A1 (es) 1985-11-01
IE55079B1 (en) 1990-05-23
GR78782B (es) 1984-10-02
ZA839291B (en) 1985-07-31
MX157826A (es) 1988-12-15
JPS59120162A (ja) 1984-07-11
US4668399A (en) 1987-05-26
ATE45502T1 (de) 1989-09-15
IE832954L (en) 1984-06-16
DK580083A (da) 1984-06-17
EP0112173A2 (en) 1984-06-27
IL70456A (en) 1988-02-29
AU570019B2 (en) 1988-03-03
ES539188A0 (es) 1986-04-01
IL70456A0 (en) 1984-03-30
ES528027A0 (es) 1985-11-01
DE3380399D1 (en) 1989-09-21
BR8306936A (pt) 1984-07-24
AU2244983A (en) 1984-06-21
CA1258642A (en) 1989-08-22

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