Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Lisac SA
Original Assignee
Lisac SA
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Publication date
Priority claimed from DD16872773Aexternal-prioritypatent/DD105447A1/xx
Application filed by Lisac SAfiledCriticalLisac SA
Priority to ES541206ApriorityCriticalpatent/ES8605272A3/en
Publication of ES541206A0publicationCriticalpatent/ES541206A0/en
Publication of ES8605272A3publicationCriticalpatent/ES8605272A3/en
4,8 -dipiperidino pyrimido (5,4-d) pyrimidine is made by (a) reacting 2,4,6,8-tetrahydroxy pyrimido (5,4-d) pyrimidine with PCl5 in POCl3 to form the tetra-chloro deriv; (b) dissolving the residue in inert organic solvent and conversion of the mixt. with piperidine and caustic soda to an acid medium of pH 1-3 by addn. of HCl or H2SO4; (c) removal of water by distn. concn. of the organic phase, taking up in methanol, boiling and cooling, when the required prod. separates out.