GB776313A - Isonicotinamide - Google Patents

Isonicotinamide

Info

Publication number
GB776313A
GB776313A GB8698/55A GB869855A GB776313A GB 776313 A GB776313 A GB 776313A GB 8698/55 A GB8698/55 A GB 8698/55A GB 869855 A GB869855 A GB 869855A GB 776313 A GB776313 A GB 776313A
Authority
GB
United Kingdom
Prior art keywords
cyanopyridine
hydrolysis
aqueous
per cent
unreacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8698/55A
Inventor
Edward James Gasson
David James Hadley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Distillers Co Yeast Ltd
Distillers Co Ltd
Original Assignee
Distillers Co Yeast Ltd
Distillers Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Distillers Co Yeast Ltd, Distillers Co Ltd filed Critical Distillers Co Yeast Ltd
Priority to GB8698/55A priority Critical patent/GB776313A/en
Publication of GB776313A publication Critical patent/GB776313A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Isonicotinamide is prepared by hydrolysis of 4-cyanopyridine in an aqueous medium at elevated temperatures in the presence of a compound having a solubility in the aqueous medium of not more than 0.1 per cent at 20 DEG C. and a pH value between 8 and 11 in the saturated aqueous solution at the same temperature, terminating the reaction when a hydrolysis conversion of not more than 75 per cent is attained and separating isonicotinamide from the unreacted 4-cyanopyridine. The hydrolysis is preferably conducted at a temperature within the range 100 DEG to 130 DEG C. The aqueous hydrolysis medium may contain a proportion of a water-miscible solvent such as aliphatic alcohols and ketones. Concentrations of 4-cyanopyridine in the aqueous medium are preferably less than 15 per cent by weight when recovery of unreacted 4-cyanopyridine is by distillation and 15 to 30 per cent or more by weight when recovery of unreacted 4-cyanopyridine is by extraction with a suitable solvent. Ammonia present in the aqueous distillate of 4-cyanopyridine may be removed by means of an ion exchange resin and the resulting solution recycled to the hydrolysis process. Direct extraction of 4-cyanopyridine from the aqueous reaction mixture may be effected with benzene, toluene, carbon tetrachloride, petroleum ether or chloroform. Specified hydrolysis catalysts are magnesium oxide, magnesium hydroxide, calcium carbonate, strontium carbonate and barium carbonate. In the Provisional Specification magnesium carbonate is also specified as a hydrolysis catalyst.
GB8698/55A 1955-03-25 1955-03-25 Isonicotinamide Expired GB776313A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB8698/55A GB776313A (en) 1955-03-25 1955-03-25 Isonicotinamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8698/55A GB776313A (en) 1955-03-25 1955-03-25 Isonicotinamide

Publications (1)

Publication Number Publication Date
GB776313A true GB776313A (en) 1957-06-05

Family

ID=9857523

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8698/55A Expired GB776313A (en) 1955-03-25 1955-03-25 Isonicotinamide

Country Status (1)

Country Link
GB (1) GB776313A (en)

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