ES8604972A1 - 6-(substituted)methylene penicillanic acid and 6-(substituted)hydroxymethylpenicillanic acid and derivatives thereof - Google Patents
6-(substituted)methylene penicillanic acid and 6-(substituted)hydroxymethylpenicillanic acid and derivatives thereofInfo
- Publication number
- ES8604972A1 ES8604972A1 ES539890A ES539890A ES8604972A1 ES 8604972 A1 ES8604972 A1 ES 8604972A1 ES 539890 A ES539890 A ES 539890A ES 539890 A ES539890 A ES 539890A ES 8604972 A1 ES8604972 A1 ES 8604972A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- acid
- cooh
- alkyl
- thienyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
6-Substd.-methylenepenams of formula (I) and their acid-addn. and n=0, 1 or 2; R1=tetrahydropyranyl, allyl, benzyl, 4-nitro-benzyl, Ph2CH, Cl3CCH2, tBu or phenacyl, as protecting gp.; H; 3-phthalidyl, 4-crotonolactonyl, qamma-butyrolacton-4-yl, CR4R5-OCOR6, CR4R5-O-COOR6, CHR4-OCOR14 or a gp. of formula (II), as an ester gp. readily hydrolysable in vivo; R4, R50H or Me; R6=1-5C alkyl; R14=gp. of formula (III); R15=2-Ph-, 2-PhO-, D-2-amino-2-Ph-, D-2-amino-2-(p-hydroxyphenyl)-, 2-COOH-2-Ph-, 2-COOH-2-(2-thienyl)-, 2-COOH-2-(3-thienyl)- or D-2-(4-ethyl-2,3-dioxopiperazino carbonylamino)-2-Ph-acetoamido or 2,2-dimethyl-4-phenyl--5imidazolidi none-1-yl; one of R2, R3=H; and the other=Cl, CH2OH, vinyl, 1-4C alkylthio, 1-4C alkylsulphonyl, furyl, thienyl, N-methylpyrrolyl, N-acetylpyrrolyl, R7C6H4, R7C6H4S, (a)-(e) X1=S, O or NR11; R7=H, 1-4C alkyl, 1-4C alkoxy, allyloxy, OH, COOH, 2-5C alkoxycarbonyl, (1-5C)alkyl-carbonyl, Ph, PhCH2, naphthyl, pyridyl, NR8R9, CONR8R9, NHCOR10, NO2, Cl Br, CF3 or SR8; R8, R9=H, 1-4C alkyl, Ph or PhCH2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57535484A | 1984-01-30 | 1984-01-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8604972A1 true ES8604972A1 (en) | 1986-02-16 |
| ES539890A0 ES539890A0 (en) | 1986-02-16 |
Family
ID=24299979
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES539890A Expired ES8604972A1 (en) | 1984-01-30 | 1985-01-28 | 6-(substituted)methylene penicillanic acid and 6-(substituted)hydroxymethylpenicillanic acid and derivatives thereof |
| ES548428A Expired ES8702916A1 (en) | 1984-01-30 | 1985-10-31 | 6-(substituted)methylene penicillanic acid and 6-(substituted)hydroxymethylpenicillanic acid and derivatives thereof |
| ES548426A Expired ES8700860A1 (en) | 1984-01-30 | 1985-10-31 | 6-(substituted)methylene penicillanic acid and 6-(substituted)hydroxymethylpenicillanic acid and derivatives thereof |
| ES548429A Expired ES8704952A1 (en) | 1984-01-30 | 1985-10-31 | 6-(substituted)methylene penicillanic acid and 6-(substituted)hydroxymethylpenicillanic acid and derivatives thereof |
| ES548427A Expired ES8705451A1 (en) | 1984-01-30 | 1985-10-31 | 6-(substituted)methylene penicillanic acid and 6-(substituted)hydroxymethylpenicillanic acid and derivatives thereof |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES548428A Expired ES8702916A1 (en) | 1984-01-30 | 1985-10-31 | 6-(substituted)methylene penicillanic acid and 6-(substituted)hydroxymethylpenicillanic acid and derivatives thereof |
| ES548426A Expired ES8700860A1 (en) | 1984-01-30 | 1985-10-31 | 6-(substituted)methylene penicillanic acid and 6-(substituted)hydroxymethylpenicillanic acid and derivatives thereof |
| ES548429A Expired ES8704952A1 (en) | 1984-01-30 | 1985-10-31 | 6-(substituted)methylene penicillanic acid and 6-(substituted)hydroxymethylpenicillanic acid and derivatives thereof |
| ES548427A Expired ES8705451A1 (en) | 1984-01-30 | 1985-10-31 | 6-(substituted)methylene penicillanic acid and 6-(substituted)hydroxymethylpenicillanic acid and derivatives thereof |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS61109791A (en) |
| KR (1) | KR880001029B1 (en) |
| CS (5) | CS248747B2 (en) |
| DD (3) | DD234015A5 (en) |
| EG (1) | EG16904A (en) |
| ES (5) | ES8604972A1 (en) |
| FI (1) | FI85376C (en) |
| HU (2) | HU194891B (en) |
| IL (1) | IL74190A (en) |
| NO (1) | NO165594C (en) |
| PL (5) | PL145130B1 (en) |
| PT (1) | PT79893B (en) |
| SU (4) | SU1395144A3 (en) |
| YU (5) | YU44770B (en) |
| ZA (1) | ZA85682B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0276942B1 (en) * | 1987-01-27 | 1992-04-01 | Pfizer Inc. | 6-beta(substituted)-(s)-hydroxymethylpenicillanic acids and derivatives thereof |
| EP0966471B1 (en) | 1997-12-29 | 2002-06-12 | Research Corporation Technologies, Inc | 2-beta-substituted-6-alkylidene penicillanic acid derivatives as beta-lactamase inhibitors |
| US6407091B1 (en) | 1999-04-15 | 2002-06-18 | Research Corporation Technologies, Inc. | β-lactamase inhibiting compounds |
| JP2005502687A (en) | 2001-07-24 | 2005-01-27 | アラムクス エルエルシー | 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors |
| JP2005525399A (en) | 2002-04-04 | 2005-08-25 | アラムクス エルエルシー | Inhibitors of serine and metallo-β-lactamases |
| GB0711776D0 (en) * | 2007-06-18 | 2007-07-25 | Syngenta Participations Ag | Substituted aromatic heterocyclic compounds as fungicides |
| JP6183053B2 (en) * | 2012-08-22 | 2017-08-23 | 宇部興産株式会社 | Method for producing tetrahydropyranylpyrimidine compound |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4272439A (en) * | 1978-06-02 | 1981-06-09 | Schering Corporation | 6-(Substituted-hydroxymethylene penams) |
| DE2927004A1 (en) * | 1979-07-04 | 1981-05-27 | Bayer Ag, 5090 Leverkusen | PENICILLANIC ACID 1,1-DIOXIDES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS AS MEDICINAL PRODUCTS |
| US4287181A (en) * | 1979-10-22 | 1981-09-01 | Pfizer Inc. | Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors |
-
1985
- 1985-01-28 DD DD272804A patent/DD234015A5/en unknown
- 1985-01-28 PT PT79893A patent/PT79893B/en not_active IP Right Cessation
- 1985-01-28 ES ES539890A patent/ES8604972A1/en not_active Expired
- 1985-01-28 SU SU853844124A patent/SU1395144A3/en active
- 1985-01-28 DD DD85286333A patent/DD247678A5/en unknown
- 1985-01-28 DD DD85286332A patent/DD247677A5/en unknown
- 1985-01-29 PL PL1985251750A patent/PL145130B1/en unknown
- 1985-01-29 ZA ZA85682A patent/ZA85682B/en unknown
- 1985-01-29 PL PL1985256016A patent/PL149797B1/en unknown
- 1985-01-29 PL PL1985256015A patent/PL147514B1/en unknown
- 1985-01-29 CS CS856933A patent/CS248747B2/en unknown
- 1985-01-29 CS CS856934A patent/CS248748B2/en unknown
- 1985-01-29 EG EG54/85A patent/EG16904A/en active
- 1985-01-29 IL IL74190A patent/IL74190A/en unknown
- 1985-01-29 PL PL1985256014A patent/PL145990B1/en unknown
- 1985-01-29 CS CS856932A patent/CS248746B2/en unknown
- 1985-01-29 CS CS85619A patent/CS248733B2/en unknown
- 1985-01-29 FI FI850375A patent/FI85376C/en not_active IP Right Cessation
- 1985-01-29 HU HU85759A patent/HU194891B/en not_active IP Right Cessation
- 1985-01-29 HU HU85322A patent/HU194567B/en not_active IP Right Cessation
- 1985-01-29 NO NO850350A patent/NO165594C/en unknown
- 1985-01-29 PL PL1985256013A patent/PL149242B1/en unknown
- 1985-01-29 KR KR1019850000547A patent/KR880001029B1/en not_active IP Right Cessation
- 1985-01-29 CS CS856935A patent/CS248749B2/en unknown
- 1985-01-30 JP JP60016368A patent/JPS61109791A/en active Pending
- 1985-01-30 YU YU140/85A patent/YU44770B/en unknown
- 1985-10-31 ES ES548428A patent/ES8702916A1/en not_active Expired
- 1985-10-31 ES ES548426A patent/ES8700860A1/en not_active Expired
- 1985-10-31 ES ES548429A patent/ES8704952A1/en not_active Expired
- 1985-10-31 ES ES548427A patent/ES8705451A1/en not_active Expired
-
1986
- 1986-03-17 SU SU864027136A patent/SU1503683A3/en active
- 1986-03-17 SU SU864027101A patent/SU1508961A3/en active
- 1986-03-17 SU SU864027223A patent/SU1396969A3/en active
-
1987
- 1987-06-25 YU YU1196/87A patent/YU44805B/en unknown
- 1987-06-25 YU YU1197/87A patent/YU44636B/en unknown
- 1987-06-25 YU YU1194/87A patent/YU44634B/en unknown
- 1987-06-25 YU YU1195/87A patent/YU44635B/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970519 |