Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Inke SA
Original Assignee
Inke SA
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Filing date
Publication date
Application filed by Inke SAfiledCriticalInke SA
Priority to ES549018ApriorityCriticalpatent/ES8604933A1/es
Publication of ES8604933A1publicationCriticalpatent/ES8604933A1/es
Publication of ES549018A0publicationCriticalpatent/ES549018A0/es
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE LA N-1-2-(4-METOXIFENIL)ETIL-4-PIPERIDINIL-1H-BENCIMIDAZOL-2-AMINA. COMPRENDE: A) HACER REACCIONAR A LA 4-AMINO-N-2-(4-METOXIFENIL)ETILPIPERIDINA DE FORMULA (II) CON EL 2-CLORO-BENCIMIDAZOL DE FORMULA (III), EN RELACION MOLAR (II/III) (1/1), EN PRESENCIA DE UN AGENTE CAPTADOR DE ACIDO COMO CO3 NA2 O TRIETILAMINA, UN ALCOHOL ISOAMILICO, N-METILPIROLIDINA O CRESOL Y A UNA TEMPERATURA ENTRE 150 Y 220JC, PARA OBTENER LA N-1-2-(4-METOXIFENIL)ETIL-4-PIPERIDINIL-1H-BENCIMIDAZOL-2-AMINA DE FORMULA (I); Y B) RECRISTALIZAR A (I) EN ETANOL O ISOPROPANOL, PARA OBTENERLO QUIMICAMENTE PURO.
ES549018A1985-11-191985-11-19Procedimiento para la obtencion de la n-(1-(2-(4-metoxife- nil)etil)-4-piperidinil)-1h-bencimidazol-2-amina
ExpiredES8604933A1
(es)