ES8604522A1 - Procedimiento para la obtencion de acidos quinoloncarboxili-cos halogenados - Google Patents
Procedimiento para la obtencion de acidos quinoloncarboxili-cos halogenadosInfo
- Publication number
- ES8604522A1 ES8604522A1 ES545255A ES545255A ES8604522A1 ES 8604522 A1 ES8604522 A1 ES 8604522A1 ES 545255 A ES545255 A ES 545255A ES 545255 A ES545255 A ES 545255A ES 8604522 A1 ES8604522 A1 ES 8604522A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- pref
- halogen
- quinolinoncarboxylic
- halogenated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 abstract 1
- UNFOICLZNBECOR-UHFFFAOYSA-N 2-quinolin-2-ylacetonitrile Chemical compound C1=CC=CC2=NC(CC#N)=CC=C21 UNFOICLZNBECOR-UHFFFAOYSA-N 0.000 abstract 1
- UTTLJDQCSWMGRE-UHFFFAOYSA-N 3-(2,4-dichloro-5-fluorophenyl)-3-oxopropanenitrile Chemical compound FC1=CC(C(=O)CC#N)=C(Cl)C=C1Cl UTTLJDQCSWMGRE-UHFFFAOYSA-N 0.000 abstract 1
- DQEGAMGTZFDDPN-UHFFFAOYSA-N 3-amino-2-benzoylprop-2-enenitrile Chemical compound NC=C(C#N)C(=O)C1=CC=CC=C1 DQEGAMGTZFDDPN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- FHPCKNJINJXSIC-UHFFFAOYSA-N ethyl 2,4-dichloro-5-fluorobenzoate Chemical compound CCOC(=O)C1=CC(F)=C(Cl)C=C1Cl FHPCKNJINJXSIC-UHFFFAOYSA-N 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical compound C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS QUINOLONCARBOXILICOS HALOGENADOS. COMPRENDE: A) CICLOCONDENSAR AL 2-BENZOIL-3-AMINOCRILONITRILO DE FORMULA (III) CON CARBONATO POTASICO, EN DIMETILFORMAMIDA Y A UNA TEMPERATURA DE 150JC, PARA OBTENER A LOS NITRILOS DE ACIDO QUINOLONCARBOXILICO DE FORMULA (II); B) SAPONIFICAR A LOS NITRILOS DE ACIDO QUINOLONCARBOXILICO DE FORMULA (II), EN MEDIO ALCALINO O ACIDO, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: R ALQUILO DE C 1 A 3, 2-FLUORETILO, FENILO Y OTROS; X HALOGENO, CLORO O BROMO; X1 Y X2 HIDROGENO O HALOGENO; Y X3 HALOGENO, CLORO O FLUOR. SE UTILIZAN COMO PRODUCTOS INTERMEDIOS PARA LA SINTESIS DE MEDICAMENTOS ANTIBACTERIAALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3426483A DE3426483A1 (de) | 1984-07-18 | 1984-07-18 | Verfahren zur herstellung von halogenierten chinoloncarbonsaeuren |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8604522A1 true ES8604522A1 (es) | 1986-02-01 |
ES545255A0 ES545255A0 (es) | 1986-02-01 |
Family
ID=6240968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES545255A Expired ES8604522A1 (es) | 1984-07-18 | 1985-07-16 | Procedimiento para la obtencion de acidos quinoloncarboxili-cos halogenados |
Country Status (12)
Country | Link |
---|---|
US (4) | US4680401A (es) |
EP (1) | EP0168737A3 (es) |
JP (1) | JPS6136265A (es) |
KR (1) | KR910003616B1 (es) |
CA (1) | CA1273936A (es) |
DD (1) | DD236524A5 (es) |
DE (1) | DE3426483A1 (es) |
DK (1) | DK325685A (es) |
ES (1) | ES8604522A1 (es) |
HU (2) | HU195488B (es) |
IL (1) | IL75812A (es) |
ZA (1) | ZA855385B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3426483A1 (de) * | 1984-07-18 | 1986-01-30 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von halogenierten chinoloncarbonsaeuren |
JPS61118370A (ja) * | 1985-10-30 | 1986-06-05 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸とその製造方法 |
US4772706A (en) * | 1986-01-13 | 1988-09-20 | Warner-Lambert Company | Process for quinoline-3-carboxylic acid antibacterial agents |
DE3615767A1 (de) * | 1986-05-10 | 1987-11-12 | Bayer Ag | Verfahren zur herstellung von 4-hydroxy-chinolin-3-carbonsaeuren |
JPS6416767A (en) * | 1987-07-09 | 1989-01-20 | Dainippon Pharmaceutical Co | 8-halogenoquinoline derivative, its ester and salt |
EP0303291B1 (en) * | 1987-08-14 | 1995-04-26 | Asahi Glass Company Ltd. | Fluorinated benzoyl compounds |
JPH0780815B2 (ja) * | 1988-08-26 | 1995-08-30 | 旭硝子株式会社 | 核フッ素化芳香族カルボン酸エステル類及びその製造方法 |
EP0355774B1 (en) * | 1988-08-26 | 1995-04-26 | Asahi Glass Company Ltd. | Nucleus-fluorinated aromatic carboxylates and processes for their production |
US5656573A (en) * | 1989-09-11 | 1997-08-12 | Rhone-Poulenc Agriculture Ltd. | Herbicidal 4-substituted isoxazoles |
US5650533A (en) * | 1989-09-11 | 1997-07-22 | Rhone-Poulenc Agriculture Ltd. | Intermediates to herbicidal 4-substituted isoxazoles |
GB8920519D0 (en) * | 1989-09-11 | 1989-10-25 | Rhone Poulenc Ltd | New compositions of matter |
US5747424A (en) * | 1989-09-11 | 1998-05-05 | Rhone-Poulenc Agriculture Ltd. | Herbicidal 4-substituted isoxazol |
US5028707A (en) * | 1989-11-20 | 1991-07-02 | Board Of Regents, University Of Texas | 4-hydroxyquinaldic acid derivatives |
US5059709A (en) * | 1990-11-13 | 1991-10-22 | American Cyanamid Company | Process for the synthesis of α-[(dialkylamino)substituted-methylene]-β-oxo-(substituted)propanentriles |
ES2036136B1 (es) * | 1991-10-16 | 1994-03-01 | Inke Sa | Procedimiento para la obtencion del acido 1-(2,4-difluorofenil)-6-fluoro-7-(3-metilpiperacinil)-4-oxo-1, 4-dihidroquinolin-3-carboxilico y sus sales. |
DE10021900A1 (de) | 2000-05-08 | 2001-11-15 | Bayer Ag | Phenyl-substituierte 2-Enamino-Ketonitrile |
US7778203B2 (en) | 2008-02-01 | 2010-08-17 | Microsoft Corporation | On-demand MAC address lookup |
CN101456825B (zh) * | 2008-12-30 | 2012-01-11 | 浙江国邦药业有限公司 | 一种丙烯腈衍生物的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2726947A (en) * | 1950-12-22 | 1955-12-13 | Goodrich Co B F | Herbicidal compositions comprising alkyl polychlorobenzoates |
GB830832A (en) * | 1957-02-15 | 1960-03-23 | Ici Ltd | New quinolones and therapeutic compositions containing them |
US3047574A (en) * | 1960-03-28 | 1962-07-31 | Searle & Co | 2-cyclohexyl-4-(2-hydroxyethyl)-3-methylmorpholine esters of substituted benzoic acids |
NL7101049A (es) * | 1970-01-28 | 1971-07-30 | ||
US4309566A (en) * | 1979-11-05 | 1982-01-05 | Fmc Corporation | Plant regulator |
DE3036967A1 (de) * | 1980-10-01 | 1982-05-13 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 3-brom-4-fluor-benzylalkohol und neue zwischenprodukte hierfuer |
DE3141659A1 (de) * | 1981-10-21 | 1983-05-05 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von in o-stellung substituierten fluoraromaten |
US4665079A (en) * | 1984-02-17 | 1987-05-12 | Warner-Lambert Company | Antibacterial agents |
DE3248506A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3248507A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | Mikrobizide mittel auf chinoloncarbonsaeure basis |
US4529725A (en) * | 1984-04-26 | 1985-07-16 | Abbott Laboratories | 1-Pyridine substituted quino-benzothiazine |
DE3426483A1 (de) * | 1984-07-18 | 1986-01-30 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von halogenierten chinoloncarbonsaeuren |
US4686221A (en) * | 1985-10-01 | 1987-08-11 | Kanebo, Ltd. | Quinolinecarboxylic acid compounds and antimicrobial agent containing the same |
-
1984
- 1984-07-18 DE DE3426483A patent/DE3426483A1/de not_active Withdrawn
-
1985
- 1985-06-28 CA CA000486146A patent/CA1273936A/en not_active Expired - Lifetime
- 1985-07-08 EP EP85108421A patent/EP0168737A3/de not_active Withdrawn
- 1985-07-12 US US06/754,563 patent/US4680401A/en not_active Expired - Fee Related
- 1985-07-15 IL IL75812A patent/IL75812A/xx unknown
- 1985-07-16 KR KR1019850005069A patent/KR910003616B1/ko not_active IP Right Cessation
- 1985-07-16 ES ES545255A patent/ES8604522A1/es not_active Expired
- 1985-07-16 DD DD85278634A patent/DD236524A5/de not_active IP Right Cessation
- 1985-07-17 HU HU872465A patent/HU195488B/hu not_active IP Right Cessation
- 1985-07-17 DK DK325685A patent/DK325685A/da not_active Application Discontinuation
- 1985-07-17 ZA ZA855385A patent/ZA855385B/xx unknown
- 1985-07-17 HU HU852747A patent/HU194177B/hu not_active IP Right Cessation
- 1985-07-17 JP JP15617085A patent/JPS6136265A/ja active Pending
-
1987
- 1987-03-24 US US07/029,939 patent/US4782156A/en not_active Expired - Fee Related
-
1988
- 1988-06-21 US US07/209,751 patent/US4914228A/en not_active Expired - Fee Related
-
1990
- 1990-01-19 US US07/467,630 patent/US4990646A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HU195488B (en) | 1988-05-30 |
DE3426483A1 (de) | 1986-01-30 |
US4782156A (en) | 1988-11-01 |
US4914228A (en) | 1990-04-03 |
DK325685A (da) | 1986-01-19 |
ZA855385B (en) | 1986-02-26 |
DD236524A5 (de) | 1986-06-11 |
US4990646A (en) | 1991-02-05 |
HUT38911A (en) | 1986-07-28 |
US4680401A (en) | 1987-07-14 |
EP0168737A2 (de) | 1986-01-22 |
EP0168737A3 (de) | 1987-11-25 |
KR860001070A (ko) | 1986-02-22 |
CA1273936A (en) | 1990-09-11 |
IL75812A0 (en) | 1985-11-29 |
IL75812A (en) | 1988-11-15 |
KR910003616B1 (ko) | 1991-06-07 |
ES545255A0 (es) | 1986-02-01 |
JPS6136265A (ja) | 1986-02-20 |
HU194177B (en) | 1988-01-28 |
DK325685D0 (da) | 1985-07-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20010402 |