ES8604477A1 - Procedimiento para preparar antraciclinonas - Google Patents

Procedimiento para preparar antraciclinonas

Info

Publication number
ES8604477A1
ES8604477A1 ES544275A ES544275A ES8604477A1 ES 8604477 A1 ES8604477 A1 ES 8604477A1 ES 544275 A ES544275 A ES 544275A ES 544275 A ES544275 A ES 544275A ES 8604477 A1 ES8604477 A1 ES 8604477A1
Authority
ES
Spain
Prior art keywords
formula
cpd
iii
reacting
reducing agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544275A
Other languages
English (en)
Other versions
ES544275A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES544275A0 publication Critical patent/ES544275A0/es
Publication of ES8604477A1 publication Critical patent/ES8604477A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ANTRACICLINONAS, DE FORMULA GENERAL (I), EN LA QUE R SIGNIFICA ALQUILO C1-C4; R1 SIGNIFICA HIDROXI; R2 Y R3 SIGNIFICAN HIDROGENO O HIDROXI; Y R4 Y R5 SIGNIFICAN HIDROGENO O HIDROXI. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R Y R1 TIENEN LOS SIGNIFICADOS YA MENCIONADOS, SEGUN UNA REACCION DE TRANSFERENCIA DE FASE, CON UNA LEJIA ALCALINA EN UN HIDROCARBURO CLORADO Y CON ADICION DE HIDROGENOSULFATO DE TETRABUTILAMONIO, PARA OBTENER UN COMPUESTO DE FORMULA GENERAL (III). A CONTINUACION DICHO COMPUESTO DE FORMULA GENERAL (III) SE HIDROLIZA PARA OBTENER EL COMPUESTO DE FORMULA GENERAL (I). DE APLICACION EN MEDICINA Y FARMACIA POR SU ACTIVIDAD ANTITUMORAL.
ES544275A 1983-08-12 1985-06-17 Procedimiento para preparar antraciclinonas Expired ES8604477A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3329185A DE3329185A1 (de) 1983-08-12 1983-08-12 Verfahren zur herstellung von anthracyclinonen

Publications (2)

Publication Number Publication Date
ES544275A0 ES544275A0 (es) 1986-02-01
ES8604477A1 true ES8604477A1 (es) 1986-02-01

Family

ID=6206423

Family Applications (3)

Application Number Title Priority Date Filing Date
ES535071A Granted ES535071A0 (es) 1983-08-12 1984-08-10 Procedimiento para preparar antraciclinonas
ES544275A Expired ES8604477A1 (es) 1983-08-12 1985-06-17 Procedimiento para preparar antraciclinonas
ES544276A Expired ES8604478A1 (es) 1983-08-12 1985-06-17 Procedimiento para preparar antraciclinonas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES535071A Granted ES535071A0 (es) 1983-08-12 1984-08-10 Procedimiento para preparar antraciclinonas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES544276A Expired ES8604478A1 (es) 1983-08-12 1985-06-17 Procedimiento para preparar antraciclinonas

Country Status (7)

Country Link
US (1) US4613464A (es)
EP (1) EP0134016B1 (es)
JP (1) JPS6058935A (es)
AT (1) ATE35129T1 (es)
DE (2) DE3329185A1 (es)
DK (1) DK388284A (es)
ES (3) ES535071A0 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4859752A (en) * 1987-09-11 1989-08-22 S. C. Johnson & Son, Inc. Alkene/excess maleic anhydride polymer manufacture

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215062A (en) * 1978-05-22 1980-07-29 University Of Kansas Endowment Association Anthracycline synthesis
FR2464937A1 (fr) * 1979-09-13 1981-03-20 Interox Procede pour la fabrication d'anthraquinones substituees
JPS59116246A (ja) * 1982-12-23 1984-07-05 Meiji Seika Kaisha Ltd 新規アンスラサイクリノンおよびその製造法

Also Published As

Publication number Publication date
ES8602583A1 (es) 1985-12-01
JPS6058935A (ja) 1985-04-05
EP0134016A3 (en) 1986-02-05
ES535071A0 (es) 1985-12-01
EP0134016A2 (de) 1985-03-13
ES544275A0 (es) 1986-02-01
DE3329185A1 (de) 1985-02-28
ATE35129T1 (de) 1988-07-15
DK388284D0 (da) 1984-08-10
ES544276A0 (es) 1986-02-01
ES8604478A1 (es) 1986-02-01
US4613464A (en) 1986-09-23
DK388284A (da) 1985-02-13
EP0134016B1 (de) 1988-06-15
DE3472100D1 (en) 1988-07-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603