ES8604193A1 - Procedimiento para la obtencion de piperacinil-oxo-quinoli- nas - Google Patents

Procedimiento para la obtencion de piperacinil-oxo-quinoli- nas

Info

Publication number
ES8604193A1
ES8604193A1 ES543820A ES543820A ES8604193A1 ES 8604193 A1 ES8604193 A1 ES 8604193A1 ES 543820 A ES543820 A ES 543820A ES 543820 A ES543820 A ES 543820A ES 8604193 A1 ES8604193 A1 ES 8604193A1
Authority
ES
Spain
Prior art keywords
antibacterial activity
quinolone compounds
compounds
aroyloxyalkyl
alkoxycarbonyloxyalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543820A
Other languages
English (en)
Other versions
ES543820A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Publication of ES8604193A1 publication Critical patent/ES8604193A1/es
Publication of ES543820A0 publication Critical patent/ES543820A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE PIPERACINIL-OXO-QUINOLINAS, DE SUS ENANTIOMEROS Y DIASTEREOISOMEROS, DE SUS HIDRATOS Y SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 ES HIDROGENO O ALQUILO INFERIOR Y R PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. COMPRENDE LA REACCION DE CICLIZACION DE DIESTERES DE FORMULA (II), EN LA QUE R TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); SEGUIDA DE LA REDUCCION DEL GRUPO NITRO DEL COMPUESTO FORMADO A GRUPO AMINA, TRATAMIENTO CON SALES DE DIETANOLAMINA N-SUSTITUIDA, DE FORMULA R1-N-(CH2CH2OH)2, EN LA QUE R1 ES METILO O BENCILOXICARBONILO, EN PRESENCIA DE BASES TERCIARIAS; Y, FINALMENTE, ALQUILACION EN POSICION 1 MEDIANTE HALUROS, SULFATOS O TOSILATOS DE ALQUILO, EN PRESENCIA DE UNA BASE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIANA.
ES543820A 1984-06-04 1985-06-03 Procedimiento para la obtencion de piperacinil-oxo-quinoli- nas Expired ES8604193A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8421241A IT1213173B (it) 1984-06-04 1984-06-04 Composti ad attivita'antibatterica, procedimento per laloro preparazione e relative composizioni farmaceutiche.

Publications (2)

Publication Number Publication Date
ES8604193A1 true ES8604193A1 (es) 1986-01-16
ES543820A0 ES543820A0 (es) 1986-01-16

Family

ID=11178899

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543820A Expired ES8604193A1 (es) 1984-06-04 1985-06-03 Procedimiento para la obtencion de piperacinil-oxo-quinoli- nas

Country Status (7)

Country Link
KR (1) KR870000286B1 (es)
BE (1) BE902586A (es)
CH (1) CH666264A5 (es)
ES (1) ES8604193A1 (es)
GB (1) GB2160519B (es)
IT (1) IT1213173B (es)
PT (1) PT80590B (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2048110A1 (es) * 1992-07-22 1994-03-01 Prodesfarma Sa Procedimiento de preparacion de 2,2-dioxidos de pirazino (2,3-c)-1,2,6-tiadiazina n(1) sustituidos.
ES2050594A1 (es) * 1991-12-31 1994-05-16 Ind Quimica Agropecuaria S A Procedimiento para la obtencion de acidos 6-fluoro-1,4-dihidro-4-oxo-7-piperazino-quinolin-3-carboxilicos sustituidos en 1-n.

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3525108A1 (de) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen Antibakteriell wirksame chinoloncarbonsaeureester
US5286754A (en) * 1986-01-21 1994-02-15 Bayer Aktiengesellschaft Pharmaceutical formulations of ciprofloxacin
DE3601566A1 (de) * 1986-01-21 1987-07-23 Bayer Ag Pharmazeutische zubereitungen von ciprofloxacin
FR2594439B1 (fr) * 1986-02-19 1989-04-21 Vetoquinol Sa Nouveaux derives ester, thioester et amide de quinolone, leur procede de preparation et leur application en therapeutique
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
US5066800A (en) * 1990-04-27 1991-11-19 Hoffmann-La Roche Inc. Qunoline intermediates useful therein for synthesizing antibacterial compounds
EP1609818B1 (de) * 2004-06-24 2010-03-10 Bayer MaterialScience AG Thermostabilisierte Polycarbonat-Zusammensetzungen
CN109942488A (zh) * 2019-04-04 2019-06-28 山东省联合农药工业有限公司 一种喹啉羧酸酯类化合物及其制备方法与用途

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2050594A1 (es) * 1991-12-31 1994-05-16 Ind Quimica Agropecuaria S A Procedimiento para la obtencion de acidos 6-fluoro-1,4-dihidro-4-oxo-7-piperazino-quinolin-3-carboxilicos sustituidos en 1-n.
ES2048110A1 (es) * 1992-07-22 1994-03-01 Prodesfarma Sa Procedimiento de preparacion de 2,2-dioxidos de pirazino (2,3-c)-1,2,6-tiadiazina n(1) sustituidos.

Also Published As

Publication number Publication date
KR860000282A (ko) 1986-01-27
PT80590A (en) 1985-07-01
ES543820A0 (es) 1986-01-16
BE902586A (fr) 1985-09-30
IT1213173B (it) 1989-12-14
GB2160519A (en) 1985-12-24
PT80590B (en) 1987-04-21
GB8513962D0 (en) 1985-07-03
KR870000286B1 (ko) 1987-02-25
IT8421241A0 (it) 1984-06-04
CH666264A5 (it) 1988-07-15
GB2160519B (en) 1988-07-20

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