ES8603412A1 - Procedimiento para la obtencion de acemetacina - Google Patents
Procedimiento para la obtencion de acemetacinaInfo
- Publication number
- ES8603412A1 ES8603412A1 ES542755A ES542755A ES8603412A1 ES 8603412 A1 ES8603412 A1 ES 8603412A1 ES 542755 A ES542755 A ES 542755A ES 542755 A ES542755 A ES 542755A ES 8603412 A1 ES8603412 A1 ES 8603412A1
- Authority
- ES
- Spain
- Prior art keywords
- acemetacin
- formula
- hal
- reacted
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960004892 acemetacin Drugs 0.000 title abstract 3
- FSQKKOOTNAMONP-UHFFFAOYSA-N acemetacin Chemical compound CC1=C(CC(=O)OCC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 FSQKKOOTNAMONP-UHFFFAOYSA-N 0.000 title abstract 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical class CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843416895 DE3416895A1 (de) | 1984-05-08 | 1984-05-08 | Verfahren zur herstellung von acemetacin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES542755A0 ES542755A0 (es) | 1985-12-16 |
| ES8603412A1 true ES8603412A1 (es) | 1985-12-16 |
Family
ID=6235188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES542755A Expired ES8603412A1 (es) | 1984-05-08 | 1985-04-30 | Procedimiento para la obtencion de acemetacina |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4600783A (enExample) |
| EP (1) | EP0163926B1 (enExample) |
| JP (1) | JPS60239465A (enExample) |
| AT (1) | ATE44527T1 (enExample) |
| DE (2) | DE3416895A1 (enExample) |
| ES (1) | ES8603412A1 (enExample) |
| GR (1) | GR851083B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030060657A1 (en) * | 1998-04-28 | 2003-03-27 | Russinsky Limited | Process for the preparation of Aceclofenac |
| CN108440374B (zh) * | 2018-05-22 | 2022-01-18 | 荆楚理工学院 | 一种阿西美辛的制备方法 |
| CN111960986A (zh) * | 2019-05-19 | 2020-11-20 | 河南东泰制药有限公司 | 一种阿西美辛的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4104278A (en) * | 1972-11-25 | 1978-08-01 | Troponwerke Dinklage & Co. | Process for the production of compounds with antiphlogistic activity |
| JPS52156862A (en) * | 1976-06-22 | 1977-12-27 | Hisamitsu Pharmaceut Co Inc | Novel indoleacetic acid ester derivatives |
| CH653326A5 (de) * | 1981-12-28 | 1985-12-31 | Siegfried Ag | Verfahren zur herstellung eines indolderivates. |
| DE3206885A1 (de) * | 1982-02-26 | 1983-09-15 | Troponwerke GmbH & Co KG, 5000 Köln | Indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3206889A1 (de) * | 1982-02-26 | 1983-09-15 | Troponwerke GmbH & Co KG, 5000 Köln | Verfahren zur herstellung von 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indolacetoxyessigsaeure |
| JPS59204172A (ja) * | 1983-04-28 | 1984-11-19 | Kowa Co | アセメタシンの製造法 |
-
1984
- 1984-05-08 DE DE19843416895 patent/DE3416895A1/de not_active Withdrawn
-
1985
- 1985-04-25 US US06/726,880 patent/US4600783A/en not_active Expired - Lifetime
- 1985-04-29 DE DE8585105194T patent/DE3571434D1/de not_active Expired
- 1985-04-29 EP EP85105194A patent/EP0163926B1/de not_active Expired
- 1985-04-29 AT AT85105194T patent/ATE44527T1/de not_active IP Right Cessation
- 1985-04-30 ES ES542755A patent/ES8603412A1/es not_active Expired
- 1985-05-02 JP JP60093959A patent/JPS60239465A/ja active Pending
- 1985-05-06 GR GR851083A patent/GR851083B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0163926A2 (de) | 1985-12-11 |
| ES542755A0 (es) | 1985-12-16 |
| DE3416895A1 (de) | 1985-11-14 |
| US4600783A (en) | 1986-07-15 |
| EP0163926A3 (en) | 1986-07-30 |
| ATE44527T1 (de) | 1989-07-15 |
| DE3571434D1 (en) | 1989-08-17 |
| JPS60239465A (ja) | 1985-11-28 |
| EP0163926B1 (de) | 1989-07-12 |
| GR851083B (enExample) | 1985-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20051011 |