ES8603412A1 - Procedimiento para la obtencion de acemetacina - Google Patents

Procedimiento para la obtencion de acemetacina

Info

Publication number
ES8603412A1
ES8603412A1 ES542755A ES542755A ES8603412A1 ES 8603412 A1 ES8603412 A1 ES 8603412A1 ES 542755 A ES542755 A ES 542755A ES 542755 A ES542755 A ES 542755A ES 8603412 A1 ES8603412 A1 ES 8603412A1
Authority
ES
Spain
Prior art keywords
acemetacin
formula
hal
reacted
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542755A
Other languages
English (en)
Other versions
ES542755A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8603412A1 publication Critical patent/ES8603412A1/es
Publication of ES542755A0 publication Critical patent/ES542755A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACEMETACINA. CONSISTE EN LA REACCION DE UNA INDOMETACINA DE FORMULA (I) CON UN HALOGENOACETATO DE TERC-BUTILO, DE FORMULA HAL-CH2-COO-C(CH3)3, EN LAS QUE HAL ES CLORO, BROMO O YODO Y R REPRESENTA UNO DE VARIOS TIPOS DE RADICALES, EN UN DISOLVENTE ORGANICO INERTE, O UNA MEZCLA DE DISOLVENTES, EN PRESENCIA DE UN CATALIZADOR DE TRANSFERENCIA DE FASES, A UNA TEMPERATURA COMPRENDIDA ENTRE C30JC Y 70JC; SEGUIDA DEL TRATAMIENTO DEL COMPUESTO FORMADO CON ACIDO SULFURICO O ACIDO SULFONICO, A TEMPERATURA ENTRE C30JC Y 120JC. ESTE COMPUESTO TIENE APLICACIONES EN MEDICINA HUMANA Y VETERINARIA COMO ANTIFLOGISTICO.
ES542755A 1984-05-08 1985-04-30 Procedimiento para la obtencion de acemetacina Granted ES542755A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843416895 DE3416895A1 (de) 1984-05-08 1984-05-08 Verfahren zur herstellung von acemetacin

Publications (2)

Publication Number Publication Date
ES8603412A1 true ES8603412A1 (es) 1985-12-16
ES542755A0 ES542755A0 (es) 1985-12-16

Family

ID=6235188

Family Applications (1)

Application Number Title Priority Date Filing Date
ES542755A Granted ES542755A0 (es) 1984-05-08 1985-04-30 Procedimiento para la obtencion de acemetacina

Country Status (7)

Country Link
US (1) US4600783A (es)
EP (1) EP0163926B1 (es)
JP (1) JPS60239465A (es)
AT (1) ATE44527T1 (es)
DE (2) DE3416895A1 (es)
ES (1) ES542755A0 (es)
GR (1) GR851083B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030060657A1 (en) * 1998-04-28 2003-03-27 Russinsky Limited Process for the preparation of Aceclofenac
CN108440374B (zh) * 2018-05-22 2022-01-18 荆楚理工学院 一种阿西美辛的制备方法
CN111960986A (zh) * 2019-05-19 2020-11-20 河南东泰制药有限公司 一种阿西美辛的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4104278A (en) * 1972-11-25 1978-08-01 Troponwerke Dinklage & Co. Process for the production of compounds with antiphlogistic activity
JPS52156862A (en) * 1976-06-22 1977-12-27 Hisamitsu Pharmaceut Co Inc Novel indoleacetic acid ester derivatives
CH653326A5 (de) * 1981-12-28 1985-12-31 Siegfried Ag Verfahren zur herstellung eines indolderivates.
DE3206885A1 (de) * 1982-02-26 1983-09-15 Troponwerke GmbH & Co KG, 5000 Köln Indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3206889A1 (de) * 1982-02-26 1983-09-15 Troponwerke GmbH & Co KG, 5000 Köln Verfahren zur herstellung von 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indolacetoxyessigsaeure
JPS59204172A (ja) * 1983-04-28 1984-11-19 Kowa Co アセメタシンの製造法

Also Published As

Publication number Publication date
EP0163926A3 (en) 1986-07-30
GR851083B (es) 1985-11-25
ES542755A0 (es) 1985-12-16
US4600783A (en) 1986-07-15
DE3571434D1 (en) 1989-08-17
JPS60239465A (ja) 1985-11-28
EP0163926A2 (de) 1985-12-11
DE3416895A1 (de) 1985-11-14
ATE44527T1 (de) 1989-07-15
EP0163926B1 (de) 1989-07-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051011