GR851083B - - Google Patents
Info
- Publication number
- GR851083B GR851083B GR851083A GR850101083A GR851083B GR 851083 B GR851083 B GR 851083B GR 851083 A GR851083 A GR 851083A GR 850101083 A GR850101083 A GR 850101083A GR 851083 B GR851083 B GR 851083B
- Authority
- GR
- Greece
- Prior art keywords
- halogenoacetate
- indometacin
- acemetacin
- tert
- butyl
- Prior art date
Links
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 229960004892 acemetacin Drugs 0.000 abstract 1
- FSQKKOOTNAMONP-UHFFFAOYSA-N acemetacin Chemical compound CC1=C(CC(=O)OCC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 FSQKKOOTNAMONP-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 229960000905 indomethacin Drugs 0.000 abstract 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843416895 DE3416895A1 (de) | 1984-05-08 | 1984-05-08 | Verfahren zur herstellung von acemetacin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR851083B true GR851083B (enExample) | 1985-11-25 |
Family
ID=6235188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR851083A GR851083B (enExample) | 1984-05-08 | 1985-05-06 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4600783A (enExample) |
| EP (1) | EP0163926B1 (enExample) |
| JP (1) | JPS60239465A (enExample) |
| AT (1) | ATE44527T1 (enExample) |
| DE (2) | DE3416895A1 (enExample) |
| ES (1) | ES8603412A1 (enExample) |
| GR (1) | GR851083B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030060657A1 (en) * | 1998-04-28 | 2003-03-27 | Russinsky Limited | Process for the preparation of Aceclofenac |
| CN108440374B (zh) * | 2018-05-22 | 2022-01-18 | 荆楚理工学院 | 一种阿西美辛的制备方法 |
| CN111960986A (zh) * | 2019-05-19 | 2020-11-20 | 河南东泰制药有限公司 | 一种阿西美辛的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4104278A (en) * | 1972-11-25 | 1978-08-01 | Troponwerke Dinklage & Co. | Process for the production of compounds with antiphlogistic activity |
| JPS52156862A (en) * | 1976-06-22 | 1977-12-27 | Hisamitsu Pharmaceut Co Inc | Novel indoleacetic acid ester derivatives |
| CH653326A5 (de) * | 1981-12-28 | 1985-12-31 | Siegfried Ag | Verfahren zur herstellung eines indolderivates. |
| DE3206885A1 (de) * | 1982-02-26 | 1983-09-15 | Troponwerke GmbH & Co KG, 5000 Köln | Indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3206889A1 (de) * | 1982-02-26 | 1983-09-15 | Troponwerke GmbH & Co KG, 5000 Köln | Verfahren zur herstellung von 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indolacetoxyessigsaeure |
| JPS59204172A (ja) * | 1983-04-28 | 1984-11-19 | Kowa Co | アセメタシンの製造法 |
-
1984
- 1984-05-08 DE DE19843416895 patent/DE3416895A1/de not_active Withdrawn
-
1985
- 1985-04-25 US US06/726,880 patent/US4600783A/en not_active Expired - Lifetime
- 1985-04-29 DE DE8585105194T patent/DE3571434D1/de not_active Expired
- 1985-04-29 EP EP85105194A patent/EP0163926B1/de not_active Expired
- 1985-04-29 AT AT85105194T patent/ATE44527T1/de not_active IP Right Cessation
- 1985-04-30 ES ES542755A patent/ES8603412A1/es not_active Expired
- 1985-05-02 JP JP60093959A patent/JPS60239465A/ja active Pending
- 1985-05-06 GR GR851083A patent/GR851083B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0163926A2 (de) | 1985-12-11 |
| ES542755A0 (es) | 1985-12-16 |
| ES8603412A1 (es) | 1985-12-16 |
| DE3416895A1 (de) | 1985-11-14 |
| US4600783A (en) | 1986-07-15 |
| EP0163926A3 (en) | 1986-07-30 |
| ATE44527T1 (de) | 1989-07-15 |
| DE3571434D1 (en) | 1989-08-17 |
| JPS60239465A (ja) | 1985-11-28 |
| EP0163926B1 (de) | 1989-07-12 |
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