ES8603172A1 - Procedimiento para la preparacion de derivados de 9-haloge- no-prostano - Google Patents

Procedimiento para la preparacion de derivados de 9-haloge- no-prostano

Info

Publication number
ES8603172A1
ES8603172A1 ES542173A ES542173A ES8603172A1 ES 8603172 A1 ES8603172 A1 ES 8603172A1 ES 542173 A ES542173 A ES 542173A ES 542173 A ES542173 A ES 542173A ES 8603172 A1 ES8603172 A1 ES 8603172A1
Authority
ES
Spain
Prior art keywords
alkyl
substd
free
functionally modified
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542173A
Other languages
English (en)
Other versions
ES542173A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES8603172A1 publication Critical patent/ES8603172A1/es
Publication of ES542173A0 publication Critical patent/ES542173A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 9-HALOGENO-PROSTANO. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON TETRACLORURO DE CARBONO/TRIFENILFOSFINA, HEXACLOROETANO/TRIFENILFOSFINA O DIMETILAMINO-TRIFLUORURO DE AZUFRE, O DESPUES DE HABER TRANSFORMADO EL GRUPO 9-HIDROXI EN UN 9-ESTER DE ACIDO SULFONICO, CON FLUORURO DE TETRA-N-BUTILAMONIO, PONER EN LIBERTAR LOS GRUPOS HIDROXI PROTEGIDOS Y/O ESTERIFICARLOS, PARA OBTENER DERIVADOS DE 9-HALOGENO-PROSTANO DE FORMULA (I) DONDE HAL ES UN ATOMO DE CLORO O FLUOR, SITUADO EN POSICION A O B; R1 SIGNIFICA EL RADICAL CH2OH U OTROS; A SIGNIFICA UN GRUPO -CH2-CH2-, TRANS-CHFCH O -CFC-; W SIGNIFICA UN GRUPO HIDROXIMETILENO Y OTROS; D Y E EN COMUN SIGNIFICAN UN ENLACE DIRECTO; R4 SIGNIFICA UN GRUPO HIDROXI LIBRE O FUNCIONALMENTE MODIFICADO; Y R5 SIGNIFICA UN ATOMO DE H, UN GRUPO ALQUILO Y OTROS. LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, A TEMPERATURA ENTRE 0 Y 80JC Y EN PRESENCIA DE UNA BASE.
ES542173A 1984-04-13 1985-04-12 Procedimiento para la preparacion de derivados de 9-haloge- no-prostano Granted ES542173A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843414509 DE3414509A1 (de) 1984-04-13 1984-04-13 Neue 9-halogen-prostaglandine

Publications (2)

Publication Number Publication Date
ES8603172A1 true ES8603172A1 (es) 1985-12-16
ES542173A0 ES542173A0 (es) 1985-12-16

Family

ID=6233830

Family Applications (1)

Application Number Title Priority Date Filing Date
ES542173A Granted ES542173A0 (es) 1984-04-13 1985-04-12 Procedimiento para la preparacion de derivados de 9-haloge- no-prostano

Country Status (12)

Country Link
EP (1) EP0213129B1 (es)
JP (1) JPS61501915A (es)
AT (1) ATE82258T1 (es)
AU (1) AU583267B2 (es)
CA (1) CA1251201A (es)
DD (1) DD234668A5 (es)
DE (2) DE3414509A1 (es)
DK (1) DK578785D0 (es)
ES (1) ES542173A0 (es)
HU (1) HU196746B (es)
IL (1) IL74877A0 (es)
WO (1) WO1985004656A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807892A (en) * 1994-09-30 1998-09-15 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1414383A (en) * 1972-11-14 1975-11-19 Syntex Corp Prostatrienoic acid derivatives and process
ES449162A1 (es) * 1975-06-23 1977-12-16 Syntex Inc Un procedimiento para la preparacion de un compuesto racemi-co u 8r-antimerico.
US4178457A (en) * 1978-07-10 1979-12-11 Syntex (U.S.A.) Inc. (dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives and processes for the production thereof
DE2950027A1 (de) * 1979-12-10 1981-06-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin 9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel

Also Published As

Publication number Publication date
DK578785A (da) 1985-12-13
IL74877A0 (en) 1985-07-31
EP0213129B1 (de) 1992-11-11
HU196746B (en) 1989-01-30
CA1251201A (en) 1989-03-14
AU4234585A (en) 1985-11-01
DK578785D0 (da) 1985-12-13
DE3414509A1 (de) 1985-10-24
HUT38307A (en) 1986-05-28
ATE82258T1 (de) 1992-11-15
WO1985004656A1 (en) 1985-10-24
AU583267B2 (en) 1989-04-27
DE3586828D1 (de) 1992-12-17
EP0213129A1 (de) 1987-03-11
JPS61501915A (ja) 1986-09-04
DE3414509C2 (es) 1992-07-02
ES542173A0 (es) 1985-12-16
DD234668A5 (de) 1986-04-09

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