AU583267B2 - 9-halogen prostane derivatives - Google Patents

9-halogen prostane derivatives

Info

Publication number
AU583267B2
AU583267B2 AU42345/85A AU4234585A AU583267B2 AU 583267 B2 AU583267 B2 AU 583267B2 AU 42345/85 A AU42345/85 A AU 42345/85A AU 4234585 A AU4234585 A AU 4234585A AU 583267 B2 AU583267 B2 AU 583267B2
Authority
AU
Australia
Prior art keywords
group
rest
formula
alkyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
AU42345/85A
Other versions
AU4234585A (en
Inventor
Walter Elger
Olaf Loge
Bernd Raduchel
Werner Skuballa
Helmut Vorbruggen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU4234585A publication Critical patent/AU4234585A/en
Application granted granted Critical
Publication of AU583267B2 publication Critical patent/AU583267B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen

Abstract

9-halogen-prostane having the formula (I) wherein Hal represents a chlorine or fluorine atom in position $g(a) or $g(b); R1? represents the rest CH2?OH or the formula (A) with R2? representing a hydrogen atom, an alkyl, cycloalkyl, aryl or heterocyclic rest or R1? represents the rest of formula (B) with R3? representing an acid rest or the rest R2?; A is a group -CH2?-CH2?-, -CH=CH- trans or -C=C-; W is free or functionally transformed hydroxy methylene group or a free or functionally transformed group having the formula (C), the group OH susceptible of being in position $g(a) or $g(b); D and E represent together a direct bound or D represents a straight branched or cyclic chain alkylene group with 1 to 10 atoms of carbon, substituted optionally by fluorine atoms, and E represents oxygen or sulfur, a direction bound, a bound -C=C- or a group -CR6?=CR7?, R6? and R7? being different and representing hydrogen, chlorine or alkyl with 1 to 4 atoms of carbon; R4? is a free or functionally modified hydroxy group; R5? is a hydrogen atom, an alkyl, a halogen-substituted alkyl, a cycloalkyl, an optionally substituted aryl or a heterocyclic group; as well as, if R2? represents a hydrogen atom, the salts thereof with physiologically acceptable bases, the preparation process thereof and the pharmaceutical utilization thereof.
AU42345/85A 1984-04-13 1985-04-12 9-halogen prostane derivatives Expired - Fee Related AU583267B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843414509 DE3414509A1 (en) 1984-04-13 1984-04-13 NEW 9-HALOGEN PROSTAGLANDINE
DE3414509 1984-04-13

Publications (2)

Publication Number Publication Date
AU4234585A AU4234585A (en) 1985-11-01
AU583267B2 true AU583267B2 (en) 1989-04-27

Family

ID=6233830

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42345/85A Expired - Fee Related AU583267B2 (en) 1984-04-13 1985-04-12 9-halogen prostane derivatives

Country Status (12)

Country Link
EP (1) EP0213129B1 (en)
JP (1) JPS61501915A (en)
AT (1) ATE82258T1 (en)
AU (1) AU583267B2 (en)
CA (1) CA1251201A (en)
DD (1) DD234668A5 (en)
DE (2) DE3414509A1 (en)
DK (1) DK578785A (en)
ES (1) ES542173A0 (en)
HU (1) HU196746B (en)
IL (1) IL74877A0 (en)
WO (1) WO1985004656A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807892A (en) * 1994-09-30 1998-09-15 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU484291B2 (en) * 1973-07-05 1975-01-09 Syntex Corporation Prostatrienoic acid derivatives and process
AU505899B2 (en) * 1975-06-23 1979-12-06 Syntex (U.S.A.) Inc. 16 phencxy frosta 4, 5, 13 trienoic acid derivatives
AU527516B2 (en) * 1978-07-10 1983-03-10 Syntex (U.S.A.) Inc. (d1)-16-phenoxy-and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1414383A (en) * 1972-11-14 1975-11-19 Syntex Corp Prostatrienoic acid derivatives and process
DE2950027A1 (en) * 1979-12-10 1981-06-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin 9-CHLORINE PROSTAGLAND DERIVATIVES, METHOD FOR THE PRODUCTION AND USE AS A MEDICINAL PRODUCT

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU484291B2 (en) * 1973-07-05 1975-01-09 Syntex Corporation Prostatrienoic acid derivatives and process
AU505899B2 (en) * 1975-06-23 1979-12-06 Syntex (U.S.A.) Inc. 16 phencxy frosta 4, 5, 13 trienoic acid derivatives
AU527516B2 (en) * 1978-07-10 1983-03-10 Syntex (U.S.A.) Inc. (d1)-16-phenoxy-and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives

Also Published As

Publication number Publication date
WO1985004656A1 (en) 1985-10-24
AU4234585A (en) 1985-11-01
HU196746B (en) 1989-01-30
ES8603172A1 (en) 1985-12-16
HUT38307A (en) 1986-05-28
CA1251201A (en) 1989-03-14
EP0213129A1 (en) 1987-03-11
ES542173A0 (en) 1985-12-16
IL74877A0 (en) 1985-07-31
DK578785D0 (en) 1985-12-13
DE3586828D1 (en) 1992-12-17
ATE82258T1 (en) 1992-11-15
JPS61501915A (en) 1986-09-04
DE3414509C2 (en) 1992-07-02
DE3414509A1 (en) 1985-10-24
DD234668A5 (en) 1986-04-09
EP0213129B1 (en) 1992-11-11
DK578785A (en) 1985-12-13

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