ES8602771A1 - Procedimiento de preparacion de derivados de indol - Google Patents

Procedimiento de preparacion de derivados de indol

Info

Publication number
ES8602771A1
ES8602771A1 ES535062A ES535062A ES8602771A1 ES 8602771 A1 ES8602771 A1 ES 8602771A1 ES 535062 A ES535062 A ES 535062A ES 535062 A ES535062 A ES 535062A ES 8602771 A1 ES8602771 A1 ES 8602771A1
Authority
ES
Spain
Prior art keywords
group
indole derivatives
alkyl
preparation
therapeutical application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535062A
Other languages
English (en)
Other versions
ES535062A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8313198A external-priority patent/FR2550532B1/fr
Priority claimed from FR8316473A external-priority patent/FR2553415B2/fr
Priority claimed from FR8318121A external-priority patent/FR2554815A2/fr
Priority claimed from FR8401998A external-priority patent/FR2559482A2/fr
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES535062A0 publication Critical patent/ES535062A0/es
Publication of ES8602771A1 publication Critical patent/ES8602771A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DEL INDOL. COMPRENDE: A) HACER REACCIONAR UN ESTER DE FORMULA (II) CON UN COMPUESTO DE FORMULA R1X, EN UN DISOLVENTE COMO ACETONA, METILETILCETONA O DIMETILFORMAMIDA, A TEMPERATURA AMBIENTE, CON YODURO DE SODIO COMO CATALIZADOR, PARA OBTENER UN COMPUESTO DE FORMULA (III); B) SOMETER A ALQUILACION CON UN HALOGENURO R2Y EN PRESENCIA DE BUTIL-LITIO Y DIISOPROPILAMINA, PARA OBTENER UN COMPUESTO DE FORMULA (IV); Y C) TRANSFORMAR EL COMPUESTO DE FORMULA (IV) CON ETILENDIAMINA, EN PRESENCIZ DE TRIMETILALUMINIO, CON AYUDA DE HIDROGENO BAJO PRESION Y CON PALADIO SOBRE CARBONO, PARA OBTENER EL COMPUESTO DE FORMULA (I), SIENDO: R1, ALQUILO DE C 1 A 6 NAFTILMETILO, Y OTROS; R2, H, ALQUILO DE C 1 A 4; R ALQUILO DE C 1 A 4; Y X E Y, ATOMOS DE BR Y I. SE UTILIZAN COMO ANTIDEPRESIVOS, HIPOTENSION, ASMA Y OBESIDAD.
ES535062A 1983-08-11 1984-08-10 Procedimiento de preparacion de derivados de indol Expired ES8602771A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8313198A FR2550532B1 (fr) 1983-08-11 1983-08-11 Derives de l'indole, leur preparation et leur application en therapeutique
FR8316473A FR2553415B2 (fr) 1983-10-17 1983-10-17 Derives de l'indole, leur preparation et leur application en therapeutique
FR8318121A FR2554815A2 (fr) 1983-11-15 1983-11-15 Derives de l'indole, leur preparation et leur application en therapeutique
FR8401998A FR2559482A2 (fr) 1984-02-09 1984-02-09 Derives de l'indole, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
ES535062A0 ES535062A0 (es) 1985-12-01
ES8602771A1 true ES8602771A1 (es) 1985-12-01

Family

ID=27446455

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535062A Expired ES8602771A1 (es) 1983-08-11 1984-08-10 Procedimiento de preparacion de derivados de indol

Country Status (16)

Country Link
US (1) US4598086A (es)
EP (1) EP0141686B1 (es)
KR (1) KR850001749A (es)
AT (1) ATE29494T1 (es)
AU (1) AU563559B2 (es)
CA (1) CA1236464A (es)
DE (1) DE3465993D1 (es)
DK (1) DK385984A (es)
ES (1) ES8602771A1 (es)
FI (1) FI843155A (es)
GR (1) GR80101B (es)
HU (1) HU192416B (es)
IL (1) IL72647A0 (es)
NO (1) NO843203L (es)
NZ (1) NZ209174A (es)
PT (1) PT79067B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0211698B1 (fr) * 1985-02-08 1991-01-30 Synthelabo Dérivés de (dihydro-4,5 1H-imidazolyl-2)-2 dihydro-2,3 indole, leur préparation et leur application en thérapeutique
US4908376A (en) * 1985-09-03 1990-03-13 Ciba-Geigy Corporation 2,3-dihydro-2-(4,5-dihydroimidazol-2-yl)-indoles in composition form for reducing intraocular pressure
US4912125A (en) * 1985-09-03 1990-03-27 Ciba-Geigy Corporation 2,3-dihydro-2-(4,5-dihydroimidazol-2-yl)-indoles for reducing intraocular pressure
GB9022858D0 (en) * 1990-10-20 1990-12-05 Reckitt & Colmann Prod Ltd Derivatives of indoles
US20020006469A1 (en) * 1996-08-14 2002-01-17 Gilles Baillet Method for incorporating additives in an ophthalmic article by means of a supercritical fluid
WO1999032112A1 (en) * 1997-12-19 1999-07-01 Eli Lilly And Company Method for treating diabetes
CN101304989A (zh) * 2005-11-11 2008-11-12 弗·哈夫曼-拉罗切有限公司 作为凝血因子xa抑制剂的碳环稠合环胺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2358890A1 (fr) * 1976-05-24 1978-02-17 Science Union & Cie Nouvelles aryl trifluoroethylamines, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
US4378357A (en) * 1977-02-03 1983-03-29 Rohm And Haas Company Novel heterocyclic compounds
IT1128095B (it) * 1979-02-22 1986-05-28 Wellcome Found Derivati imidazolici e loro sali dotati di attivita farmacologica e procedimento per la loro preparazione
US4280327A (en) * 1979-04-30 1981-07-28 The Garrett Corporation Solar powered turbine system
DE3049405A1 (de) * 1980-12-23 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue derivate von antiphlogistisch wirksamen carbonsaeuren, ihre herstellung und medizinische anwendung
NZ201219A (en) * 1981-07-28 1984-10-19 Reckitt & Colmann Prod Ltd Dihydrobenzofuranyl-2-imidazolines and pharmaceutical compositions
DE3141063A1 (de) * 1981-10-13 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

Also Published As

Publication number Publication date
GR80101B (en) 1984-12-14
EP0141686A1 (fr) 1985-05-15
KR850001749A (ko) 1985-04-01
NO843203L (no) 1985-02-12
DK385984D0 (da) 1984-08-10
DE3465993D1 (en) 1987-10-15
PT79067B (fr) 1986-11-14
CA1236464A (en) 1988-05-10
PT79067A (fr) 1984-09-01
IL72647A0 (en) 1984-11-30
FI843155A (fi) 1985-02-12
HU192416B (en) 1987-06-29
FI843155A0 (fi) 1984-08-10
DK385984A (da) 1985-02-12
NZ209174A (en) 1986-12-05
HUT35670A (en) 1985-07-29
ATE29494T1 (de) 1987-09-15
US4598086A (en) 1986-07-01
ES535062A0 (es) 1985-12-01
AU563559B2 (en) 1987-07-16
EP0141686B1 (fr) 1987-09-09
AU3180284A (en) 1985-02-14

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