ES8602718A1 - Procedimiento para la preparacion de derivados de tiazolidina. - Google Patents

Procedimiento para la preparacion de derivados de tiazolidina.

Info

Publication number
ES8602718A1
ES8602718A1 ES541707A ES541707A ES8602718A1 ES 8602718 A1 ES8602718 A1 ES 8602718A1 ES 541707 A ES541707 A ES 541707A ES 541707 A ES541707 A ES 541707A ES 8602718 A1 ES8602718 A1 ES 8602718A1
Authority
ES
Spain
Prior art keywords
preparation
thiazolidine derivatives
pharmaceutical preparations
hydrogen
intermediates therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541707A
Other languages
English (en)
Other versions
ES541707A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8602718A1 publication Critical patent/ES8602718A1/es
Publication of ES541707A0 publication Critical patent/ES541707A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE TIAZOLIDINA. COMPRENDE TRATAR AL COMPUESTO DE FORMULA GENERAL (II) CON UN AGENTE ACILANTE O ALQUILANTE, SIENDO R21 AMINO O HIDROXILO, PARA OBTENER COMPUESTOS DE FORMULA GENERAL (I), DONDE X SIGNIFICA METILENO, OXIGENO O AZUFRE; R1 SIGNIFICA HALOGENO; R2 SIGNIFICA OR3 O NHR3; R3 SIGNIFICA ALQUILO, ACILO O UN GRUPO -CO-OR4 O -CO-NHR4; Y R4 SIGNIFICA ALQUILO, ARILO O ARALQUILO, Y SUS SALES CON CATIONES FISIOLOGICAMENTE COMPATIBLES. APLICACION PARA EL TRATAMIENTO DE DIABETES MELLITUS Y PARA LA PREVENCION DE COMPLICACIONES COMO CATARATAS Y NEUROPATIAS ASOCIADAS A ELLA.
ES541707A 1983-06-23 1985-03-29 Procedimiento para la preparacion de derivados de tiazolidina. Granted ES541707A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH343283 1983-06-23
CH186084 1984-04-13

Publications (2)

Publication Number Publication Date
ES8602718A1 true ES8602718A1 (es) 1985-12-01
ES541707A0 ES541707A0 (es) 1985-12-01

Family

ID=25688868

Family Applications (4)

Application Number Title Priority Date Filing Date
ES533624A Expired ES8602820A1 (es) 1983-06-23 1984-06-22 Procedimiento para la preparacion de derivados de tiazolidina
ES541707A Granted ES541707A0 (es) 1983-06-23 1985-03-29 Procedimiento para la preparacion de derivados de tiazolidina.
ES541705A Expired ES8602716A1 (es) 1983-06-23 1985-03-29 Procedimiento para la preparacion de derivados de tiazolidina.
ES541708A Expired ES8602719A1 (es) 1983-06-23 1985-03-29 Procedimiento para la preparacion de derivados de tiazolidina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES533624A Expired ES8602820A1 (es) 1983-06-23 1984-06-22 Procedimiento para la preparacion de derivados de tiazolidina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES541705A Expired ES8602716A1 (es) 1983-06-23 1985-03-29 Procedimiento para la preparacion de derivados de tiazolidina.
ES541708A Expired ES8602719A1 (es) 1983-06-23 1985-03-29 Procedimiento para la preparacion de derivados de tiazolidina.

Country Status (11)

Country Link
US (1) US4587256A (es)
EP (1) EP0129747A3 (es)
AU (1) AU2947784A (es)
DK (1) DK277484A (es)
ES (4) ES8602820A1 (es)
FI (1) FI842327A (es)
HU (1) HUT34509A (es)
IL (1) IL72139A0 (es)
MC (1) MC1601A1 (es)
NO (1) NO842515L (es)
PT (1) PT78778B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537892A (en) * 1983-09-14 1985-08-27 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
JPH06772B2 (ja) * 1984-07-09 1994-01-05 鐘淵化学工業株式会社 ３―（４―フルオロフエノキシ）プロピオニトリルを用いる６―フルオロ―４―クロマノンの製造法
JPS61200991A (ja) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US6756360B1 (en) 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
IL149887A0 (en) * 1999-12-22 2002-11-10 Metabasis Therapeutics Inc Novel bisamidate phosphonate prodrugs
US7563774B2 (en) * 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US20070281938A1 (en) * 2004-05-24 2007-12-06 Amgen Inc. Inhibitors of 11-Beta-Hydroxy Steroid Dehydrogenase Type 1
US8686011B2 (en) 2004-05-24 2014-04-01 Amgen Inc. Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
BRPI0514372A (pt) * 2004-08-18 2008-06-10 Metabasis Therapeutics Inc inibidores de tiazol de frutose 1, 6-bisfosfatase
US7828840B2 (en) * 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
CN115322208B (zh) * 2021-05-10 2023-04-11 中国药科大学 2-氨基噻唑类衍生物及其制备方法和医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210756A (en) * 1976-10-18 1980-07-01 Pfizer Inc. Tetrahydroquinoline hydantoins for chronic diabetic complications
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4226875A (en) * 1979-04-02 1980-10-07 Pfizer Inc. Novel spiro-oxazolidinediones
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines

Also Published As

Publication number Publication date
ES541705A0 (es) 1985-12-01
HUT34509A (en) 1985-03-28
ES533624A0 (es) 1985-12-16
ES8602716A1 (es) 1985-12-01
US4587256A (en) 1986-05-06
ES541708A0 (es) 1985-12-01
DK277484D0 (da) 1984-06-04
MC1601A1 (fr) 1985-05-09
ES8602719A1 (es) 1985-12-01
DK277484A (da) 1984-12-24
IL72139A0 (en) 1984-10-31
PT78778A (en) 1984-07-01
ES8602820A1 (es) 1985-12-16
NO842515L (no) 1984-12-27
EP0129747A3 (de) 1985-09-25
FI842327A (fi) 1984-12-24
EP0129747A2 (de) 1985-01-02
AU2947784A (en) 1985-01-03
PT78778B (en) 1986-09-15
FI842327A0 (fi) 1984-06-08
ES541707A0 (es) 1985-12-01

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