ES8602654A1 - Procedimiento para la obtencion de nuevos derivados de la piperidina - Google Patents
Procedimiento para la obtencion de nuevos derivados de la piperidinaInfo
- Publication number
- ES8602654A1 ES8602654A1 ES541109A ES541109A ES8602654A1 ES 8602654 A1 ES8602654 A1 ES 8602654A1 ES 541109 A ES541109 A ES 541109A ES 541109 A ES541109 A ES 541109A ES 8602654 A1 ES8602654 A1 ES 8602654A1
- Authority
- ES
- Spain
- Prior art keywords
- piperidine derivatives
- compounds
- formula
- preparation
- medicines based
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Hydrogenated Pyridines (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE NUEVOS DERIVADOS DE LA PIPERIDINA.COMPRENDE: A) CONDENSAR UN ESTER DE FORMULA (II) CON UN ESTER DE ACIDO (PIPERIDINOL-4) PROPIONICO DE FORMULA (III), EN PRESENCIA DE UNA BASE, TAL COMO UN ALCOHOLATO O UN HIDRURO METALICO, EN UN DISOLVENTE INERTE TAL COMO UN HIDROCARBURO A UNA TEMPERATURA QUE VARIA DE 0 C A LA TEMPERATURA DE EBULLICION DEL DISOLVENTE, PARA OBTENER UN COMPUESTO DE FORMULA (IV); Y B) HIDROLIZAR Y DESCARBOXILAR EL COMPUESTO DE CONDENSACION DE FORMULA (IV), PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: AR, RESTO AROMATICO ELEGIDO LOS CICLOS (A), (D) O (C); B, GRUPO PROTECTOR DE LA FUNCION AMINA ESTABLE EN MEDIO ALCALINO ANHIDRO; R, H O GRUPO ALQUILO DE C1 A 4; R1, GRUPO ALQUILO DE C1 A 2; R2, GRUPO ALQUILO DE C1 A 2; X, GRUPO -CO-; Y, H O GRUPO ALCOXI DE C1 A 3; Y Z, H O GRUPO ALCOXI DE C1 A 3. SE UTILIZA PARA EL TRATAMIENTO DE LOS TRASTORNOS DEL RITMO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8403670A FR2560873B1 (fr) | 1984-03-09 | 1984-03-09 | Medicaments a base de derives de la piperidine, nouveaux derives de la piperidine et leurs procedes de preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
ES541109A0 ES541109A0 (es) | 1985-12-01 |
ES8602654A1 true ES8602654A1 (es) | 1985-12-01 |
Family
ID=9301879
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES541109A Expired ES8602654A1 (es) | 1984-03-09 | 1985-03-08 | Procedimiento para la obtencion de nuevos derivados de la piperidina |
ES543345A Expired ES8700235A1 (es) | 1984-03-09 | 1985-05-21 | Procedimiento para la obtencion de nuevos derivados de la piperidina |
ES543346A Granted ES543346A0 (es) | 1984-03-09 | 1985-05-21 | Procedimiento para la obtencion de nuevos derivados de la piperidina |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES543345A Expired ES8700235A1 (es) | 1984-03-09 | 1985-05-21 | Procedimiento para la obtencion de nuevos derivados de la piperidina |
ES543346A Granted ES543346A0 (es) | 1984-03-09 | 1985-05-21 | Procedimiento para la obtencion de nuevos derivados de la piperidina |
Country Status (14)
Country | Link |
---|---|
US (1) | US4665076A (es) |
EP (1) | EP0173585B1 (es) |
JP (1) | JPS60204762A (es) |
AT (1) | ATE36705T1 (es) |
AU (1) | AU570541B2 (es) |
CA (1) | CA1217489A (es) |
DE (1) | DE3564572D1 (es) |
DK (1) | DK109285A (es) |
ES (3) | ES8602654A1 (es) |
FR (1) | FR2560873B1 (es) |
HU (1) | HU194846B (es) |
IL (1) | IL74533A (es) |
MA (1) | MA20369A1 (es) |
ZA (1) | ZA851698B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4921863A (en) * | 1988-02-17 | 1990-05-01 | Eisai Co., Ltd. | Cyclic amine derivatives |
GB9310582D0 (en) * | 1993-05-22 | 1993-07-07 | Smithkline Beecham Plc | Pharmaceuticals |
US6894062B1 (en) | 2002-11-12 | 2005-05-17 | Pfizer Inc. | Quinoline derivatives |
MXPA05005111A (es) * | 2002-11-12 | 2005-07-01 | Pfizer Prod Inc | Derivados de quinolina. |
JP5682051B2 (ja) * | 2006-05-18 | 2015-03-11 | ファーマサイクリックス,インク. | 細胞内キナーゼ阻害剤 |
CN106117138B (zh) * | 2016-06-29 | 2018-06-15 | 云南中烟工业有限责任公司 | 一种具有抗菌活性的异喹啉生物碱类化合物、其制备方法和应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1197456B (de) * | 1960-06-24 | 1965-07-29 | Ruetgerswerke Ag | Verfahren zur Herstellung von Vinyl-verbindungen der Pyridin- und Chinolinreihe |
US3857847A (en) * | 1968-07-02 | 1974-12-31 | Hoffmann La Roche | 6,7 substituted 4 (3{8 3(r) alkyl, 4(s)piperidyl{9 -2-oxopropyl)quinoline and racemates |
BE791088A (fr) * | 1971-11-09 | 1973-03-01 | Richardson Merrell Inc | Nouveaux derives d'aryl (piperidyl-4) cetone, utiles notamment comme analgesiques et anticoagulants, et leur procede de preparation |
FR2443246A1 (fr) * | 1978-12-05 | 1980-07-04 | Pharmindustrie | Nouveaux medicaments a base de derives de la phenyl-1 (piperidyl-4)-3 propanone-1 |
US4246268A (en) * | 1979-02-09 | 1981-01-20 | Richardson-Merrell Inc. | Neuroleptic-4-(naphthylmethyl)piperidine derivatives |
-
1984
- 1984-03-09 FR FR8403670A patent/FR2560873B1/fr not_active Expired
-
1985
- 1985-03-05 MA MA20593A patent/MA20369A1/fr unknown
- 1985-03-06 AU AU39557/85A patent/AU570541B2/en not_active Ceased
- 1985-03-06 US US06/709,066 patent/US4665076A/en not_active Expired - Fee Related
- 1985-03-06 ZA ZA851698A patent/ZA851698B/xx unknown
- 1985-03-07 DE DE8585400438T patent/DE3564572D1/de not_active Expired
- 1985-03-07 EP EP85400438A patent/EP0173585B1/fr not_active Expired
- 1985-03-07 CA CA000475991A patent/CA1217489A/fr not_active Expired
- 1985-03-07 IL IL74533A patent/IL74533A/xx unknown
- 1985-03-07 AT AT85400438T patent/ATE36705T1/de not_active IP Right Cessation
- 1985-03-08 JP JP60044958A patent/JPS60204762A/ja active Pending
- 1985-03-08 ES ES541109A patent/ES8602654A1/es not_active Expired
- 1985-03-08 HU HU85878A patent/HU194846B/hu not_active IP Right Cessation
- 1985-03-08 DK DK109285A patent/DK109285A/da unknown
- 1985-05-21 ES ES543345A patent/ES8700235A1/es not_active Expired
- 1985-05-21 ES ES543346A patent/ES543346A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
CA1217489A (fr) | 1987-02-03 |
DK109285A (da) | 1985-09-10 |
ES541109A0 (es) | 1985-12-01 |
ES8603829A1 (es) | 1986-01-01 |
EP0173585B1 (fr) | 1988-08-24 |
HU194846B (en) | 1988-03-28 |
MA20369A1 (fr) | 1985-10-01 |
AU570541B2 (en) | 1988-03-17 |
ES543346A0 (es) | 1986-01-01 |
ZA851698B (en) | 1985-10-30 |
ATE36705T1 (de) | 1988-09-15 |
ES543345A0 (es) | 1986-10-01 |
HUT37413A (en) | 1985-12-28 |
AU3955785A (en) | 1985-09-12 |
EP0173585A1 (fr) | 1986-03-05 |
FR2560873B1 (fr) | 1986-09-26 |
DK109285D0 (da) | 1985-03-08 |
DE3564572D1 (en) | 1988-09-29 |
JPS60204762A (ja) | 1985-10-16 |
US4665076A (en) | 1987-05-12 |
IL74533A0 (en) | 1985-06-30 |
FR2560873A1 (fr) | 1985-09-13 |
ES8700235A1 (es) | 1986-10-01 |
IL74533A (en) | 1988-03-31 |
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