ES8600301A1 - Un procedimiento para la preparacion de una (4a, 11b)-3, 4, 4a, 5, 6, 11b-hexahidro-2h-(1) benzoxepino-(5, 4-b)-1, 4-oxazina - Google Patents
Un procedimiento para la preparacion de una (4a, 11b)-3, 4, 4a, 5, 6, 11b-hexahidro-2h-(1) benzoxepino-(5, 4-b)-1, 4-oxazinaInfo
- Publication number
- ES8600301A1 ES8600301A1 ES529720A ES529720A ES8600301A1 ES 8600301 A1 ES8600301 A1 ES 8600301A1 ES 529720 A ES529720 A ES 529720A ES 529720 A ES529720 A ES 529720A ES 8600301 A1 ES8600301 A1 ES 8600301A1
- Authority
- ES
- Spain
- Prior art keywords
- benzoxepino
- oxazine
- oxazine derivatives
- acylating
- trans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IHKALFITVBQHPG-UHFFFAOYSA-N 2h-[1]benzoxepino[5,4-b][1,4]oxazine Chemical class C1=COC2=CC=CC=C2C2=C1N=CCO2 IHKALFITVBQHPG-UHFFFAOYSA-N 0.000 title abstract 3
- -1 trans-(4a Chemical compound 0.000 abstract 2
- YRMMRFYPKHSIDT-PSASIEDQSA-N (4r,5r)-4-amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ol Chemical compound O[C@H]1[C@H](N)CCOC2=CC=CC=C21 YRMMRFYPKHSIDT-PSASIEDQSA-N 0.000 abstract 1
- XISPDFMAOWZEQG-UHFFFAOYSA-N 4h-1,4-oxazin-3-one Chemical compound O=C1COC=CN1 XISPDFMAOWZEQG-UHFFFAOYSA-N 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46640783A | 1983-02-15 | 1983-02-15 | |
| US56275983A | 1983-12-21 | 1983-12-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8600301A1 true ES8600301A1 (es) | 1985-10-01 |
| ES529720A0 ES529720A0 (es) | 1985-10-01 |
Family
ID=27041648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES529720A Granted ES529720A0 (es) | 1983-02-15 | 1984-02-14 | Un procedimiento para la preparacion de una (4a, 11b)-3, 4, 4a, 5, 6, 11b-hexahidro-2h-(1) benzoxepino-(5, 4-b)-1, 4-oxazina |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0116373B1 (enEXAMPLES) |
| KR (1) | KR900005471B1 (enEXAMPLES) |
| AU (1) | AU561700B2 (enEXAMPLES) |
| CA (1) | CA1236833A (enEXAMPLES) |
| DE (1) | DE3463142D1 (enEXAMPLES) |
| DK (1) | DK158986C (enEXAMPLES) |
| ES (1) | ES529720A0 (enEXAMPLES) |
| GR (1) | GR81510B (enEXAMPLES) |
| IE (1) | IE56788B1 (enEXAMPLES) |
| IL (1) | IL70941A (enEXAMPLES) |
| NO (1) | NO167571C (enEXAMPLES) |
| NZ (1) | NZ207110A (enEXAMPLES) |
| PH (1) | PH22343A (enEXAMPLES) |
| PT (1) | PT78109B (enEXAMPLES) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE939614C (de) * | 1949-02-26 | 1956-02-23 | Ernst Rodenhaeuser | Kolbendichtung fuer Kolbenfuellhalter |
| NZ207111A (en) * | 1983-02-15 | 1986-07-11 | Merrell Dow Pharma | (4a,11b)-3,4,4a,5,6,11b-hexahydro-2h-(1)benzoxepino(5,4-b)-1,4 oxazine derivatives and pharmaceutical compositions |
| US4766212A (en) * | 1983-02-15 | 1988-08-23 | Merrell Dow Pharmaceuticals Inc. | 2H-[1]benzoxepino[5,4-b]-1,4-oxazine derivatives |
| FR2698873B1 (fr) * | 1992-12-07 | 1995-02-24 | Lipha | Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant. |
| CA2800220C (en) | 2010-05-21 | 2019-04-30 | Research Triangle Institute | Phenylmorpholines and analogues thereof |
| WO2011146821A2 (en) | 2010-05-21 | 2011-11-24 | Research Triangle Institute | 1 - phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1593760A1 (de) * | 1967-02-01 | 1972-06-08 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung neuer Benz-epinderivate |
-
1984
- 1984-02-10 PH PH30228A patent/PH22343A/en unknown
- 1984-02-10 NZ NZ207110A patent/NZ207110A/en unknown
- 1984-02-13 CA CA000447245A patent/CA1236833A/en not_active Expired
- 1984-02-13 IL IL70941A patent/IL70941A/xx not_active IP Right Cessation
- 1984-02-13 AU AU24542/84A patent/AU561700B2/en not_active Ceased
- 1984-02-13 GR GR73786A patent/GR81510B/el unknown
- 1984-02-14 DK DK066284A patent/DK158986C/da active
- 1984-02-14 KR KR1019840000692A patent/KR900005471B1/ko not_active Expired
- 1984-02-14 ES ES529720A patent/ES529720A0/es active Granted
- 1984-02-14 EP EP84101520A patent/EP0116373B1/en not_active Expired
- 1984-02-14 NO NO840534A patent/NO167571C/no unknown
- 1984-02-14 DE DE8484101520T patent/DE3463142D1/de not_active Expired
- 1984-02-14 IE IE334/84A patent/IE56788B1/en not_active IP Right Cessation
- 1984-02-15 PT PT78109A patent/PT78109B/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PH22343A (en) | 1988-08-12 |
| AU2454284A (en) | 1984-08-23 |
| DK158986B (da) | 1990-08-13 |
| ES529720A0 (es) | 1985-10-01 |
| IL70941A0 (en) | 1984-05-31 |
| PT78109A (en) | 1984-03-01 |
| KR900005471B1 (ko) | 1990-07-30 |
| KR840007729A (ko) | 1984-12-10 |
| NZ207110A (en) | 1986-05-09 |
| DK66284D0 (da) | 1984-02-14 |
| DE3463142D1 (de) | 1987-05-21 |
| IE56788B1 (en) | 1991-12-18 |
| IL70941A (en) | 1987-12-31 |
| PT78109B (en) | 1986-05-20 |
| CA1236833A (en) | 1988-05-17 |
| EP0116373B1 (en) | 1987-04-15 |
| NO167571C (no) | 1991-11-20 |
| EP0116373A1 (en) | 1984-08-22 |
| DK158986C (da) | 1991-01-07 |
| IE840334L (en) | 1984-08-15 |
| AU561700B2 (en) | 1987-05-14 |
| NO167571B (no) | 1991-08-12 |
| NO840534L (no) | 1984-08-16 |
| GR81510B (enEXAMPLES) | 1984-12-11 |
| DK66284A (da) | 1984-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20040601 |