ES8600245A1 - Un procedimiento para preparar derivados de piridina. - Google Patents

Un procedimiento para preparar derivados de piridina.

Info

Publication number
ES8600245A1
ES8600245A1 ES527994A ES527994A ES8600245A1 ES 8600245 A1 ES8600245 A1 ES 8600245A1 ES 527994 A ES527994 A ES 527994A ES 527994 A ES527994 A ES 527994A ES 8600245 A1 ES8600245 A1 ES 8600245A1
Authority
ES
Spain
Prior art keywords
alkyl
group
formula
chem
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527994A
Other languages
English (en)
Other versions
ES527994A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838322347A external-priority patent/GB8322347D0/en
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES8600245A1 publication Critical patent/ES8600245A1/es
Publication of ES527994A0 publication Critical patent/ES527994A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE PIRIDINA.COMPRENDE HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) Y EL PRODUCTO RESULTANTE HACERLO REACCIONAR CON UNA AMINA DE FORMULA (IV), PARA OBTENER UN COMPUESTO DERIVADO DE PIRIDINA DE FORMULA (I) O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE R1 ES HALOGENO, NITRO, AMINO O ALQUILO C 1 A 4; R2 ES HALOGENO, NITRO U OTROS; R3 ES UN GRUPO ALQUILENO C 1 A 3; Y R4 ES UN GRUPO DE FORMULA (V) DONDE R5 ES NCN, NNO2 NH O CHNO2, Y R6 ES HIDROXI, AMINO, ALQUILO C 1 A 6 U OTROS. LA REACCION SE LLEVA A CABO EN PRESENCIA DE UN DISOLVENTE Y A TEMPERATURAS ELEVADAS COMO LA DEL PUNTO DE EBULLICION DE LA MEZCLA DE REACCION.SE UTILIZAN FARMACEUTICAMENTE PARA EL TRATAMIENTO DE ENFERMEDADES COMO EL ASMA BRONQUIAL, LA RINITIS, LA FIEBRE DEL HENO Y OTRAS.
ES527994A 1982-12-14 1983-12-13 Un procedimiento para preparar derivados de piridina. Granted ES527994A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8235590 1982-12-14
GB838322347A GB8322347D0 (en) 1983-08-19 1983-08-19 Pyridine derivatives

Publications (2)

Publication Number Publication Date
ES8600245A1 true ES8600245A1 (es) 1985-10-01
ES527994A0 ES527994A0 (es) 1985-10-01

Family

ID=26284681

Family Applications (3)

Application Number Title Priority Date Filing Date
ES527994A Granted ES527994A0 (es) 1982-12-14 1983-12-13 Un procedimiento para preparar derivados de piridina.
ES543728A Expired ES8605513A1 (es) 1982-12-14 1985-05-31 Un procedimiento para preparar derivados de piridina
ES543729A Expired ES8607241A1 (es) 1982-12-14 1985-05-31 Un procedimiento para preparar derivados de piridina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES543728A Expired ES8605513A1 (es) 1982-12-14 1985-05-31 Un procedimiento para preparar derivados de piridina
ES543729A Expired ES8607241A1 (es) 1982-12-14 1985-05-31 Un procedimiento para preparar derivados de piridina

Country Status (8)

Country Link
US (2) US4532252A (es)
EP (1) EP0112142B1 (es)
AU (1) AU2222083A (es)
DE (1) DE3381674D1 (es)
DK (1) DK572583A (es)
ES (3) ES527994A0 (es)
GR (1) GR79163B (es)
PT (1) PT77808B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8301063A (nl) * 1982-03-29 1983-10-17 Bristol Myers Co Gesubstitueerde 3,4-diamino-1,2,5-thiadiazolen met histamine h2-receptor antagonistische werkzaamheid; gesubstitueerde ethaandiimidamiden.
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives
PT78358B (en) * 1983-04-07 1986-05-30 Smith Kline French Lab Chemical process
US4728648A (en) * 1985-02-09 1988-03-01 Smith Kline & French Laboratories Limited Histamine antagonist triadiazole derivatives, compositions, and method of use therefor
CA1286297C (en) * 1985-06-13 1991-07-16 George S. Sach Pyridine derivatives
GB8610867D0 (en) * 1986-05-02 1986-06-11 Smith Kline French Lab 3-hydroxypyridines
IE71183B1 (en) * 1988-12-27 1997-01-29 Takeda Chemical Industries Ltd Guanidine derivatives their production and insecticides
NZ332859A (en) * 1996-06-17 2000-06-23 American Home Prod pyridinyl, pyrimidinyl or benzofuranyl methylamino substituted cyclobutene-3,4-dione derivatives
US5872139A (en) * 1996-06-17 1999-02-16 American Home Products Corporation Heterocyclymethylamino derivatives of cyclobutene-3,4-diones
ATE422203T1 (de) * 2002-10-09 2009-02-15 Schering Corp Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden
MXPA06007076A (es) * 2003-12-19 2006-08-31 Pharmacopeia Drug Discovery Tiadiazoles como ligandos del receptor cxc y cc-quimiocina.
JP4851943B2 (ja) * 2003-12-22 2012-01-11 シェーリング コーポレイション Ｃｘｃ−ケモカインレセプターリガンドおよびｃｃ−ケモカインレセプターリガンドとしてのイソチアゾールジオキシド
ES2327840T3 (es) * 2004-12-23 2009-11-04 Gpc Biotech Ag Derivados de acido escuarico con actividad antiproliferativa.
JP2009500328A (ja) * 2005-06-29 2009-01-08 シェーリング コーポレイション Ｃｘｃ−ケモカインレセプターリガンドとしての５，６−ジ−置換オキサジアゾロピラジンおよびチアジアゾロピラジン
EP1912971A2 (en) * 2005-06-29 2008-04-23 Shering Corporation Di-substituted oxadiazoles as cxc-chemokine receptor ligands
US8450348B2 (en) * 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3535328A (en) * 1967-09-01 1970-10-20 Exxon Research Engineering Co Certain substituted aminothioethoxy pyridines
US3968216A (en) * 1969-10-29 1976-07-06 Smith Kline & French Laboratories Limited Method of inhibiting histamine activity with guanidine compounds
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
GB1497260A (en) * 1974-06-28 1978-01-05 Smith Kline French Lab Guanidine derivatives
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
US4120973A (en) * 1975-07-31 1978-10-17 Smithkline & French Laboratories Limited Imidazolyl alkylaminocyclobutenediones
GB1595291A (en) * 1976-09-21 1981-08-12 Smith Kline French Lab Pyrimidone and thiopyrimidone derivatives
US4210658A (en) * 1977-09-08 1980-07-01 Smith Kline & French Laboratories Limited Amidinosulphonic acid derivatives
IL57415A (en) * 1978-05-30 1984-08-31 Smith Kline French Lab Nitropyrrole compounds,process for preparing them and pharmaceutical compositions containing them
ZA792608B (en) * 1978-05-30 1980-06-25 Smith Kline French Lab Nitro compounds
US4250316A (en) * 1978-11-24 1981-02-10 Bristol-Myers Company Pyridyl guanidine anti-ulcer agents
US4394508A (en) * 1980-06-07 1983-07-19 Bristol-Myers Company Chemical compounds
US4380639A (en) * 1981-03-03 1983-04-19 Bristol-Myers Company Substituted 1,2,5-thiadiazole derivatives
US4503051A (en) * 1981-05-18 1985-03-05 Bristol-Myers Company Substituted 3-cyclobutene-1,2-diones, pharmaceutical compositions thereof and methods of use
US4390701A (en) * 1981-05-18 1983-06-28 Bristol-Myers Company 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione
NL8301063A (nl) * 1982-03-29 1983-10-17 Bristol Myers Co Gesubstitueerde 3,4-diamino-1,2,5-thiadiazolen met histamine h2-receptor antagonistische werkzaamheid; gesubstitueerde ethaandiimidamiden.
US4528375A (en) * 1982-03-29 1985-07-09 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
GB2131683B (en) * 1982-12-11 1986-03-12 Alma Ruby Skelcher Walking aid foot device
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives
PT77855B (en) * 1982-12-23 1986-04-16 Smith Kline French Lab Pyridine derivatives
US4440933A (en) * 1983-03-16 1984-04-03 Bristol-Myers Company Process for preparing 1,2,5-thiadiazoles

Also Published As

Publication number Publication date
EP0112142A2 (en) 1984-06-27
DE3381674D1 (de) 1990-07-26
EP0112142A3 (en) 1986-01-15
US4640926A (en) 1987-02-03
US4532252A (en) 1985-07-30
PT77808B (en) 1986-03-26
DK572583A (da) 1984-06-15
GR79163B (es) 1984-10-02
ES543728A0 (es) 1986-03-16
ES8607241A1 (es) 1986-05-16
DK572583D0 (da) 1983-12-13
ES543729A0 (es) 1986-05-16
ES8605513A1 (es) 1986-03-16
ES527994A0 (es) 1985-10-01
EP0112142B1 (en) 1990-06-20
PT77808A (en) 1984-01-01
AU2222083A (en) 1984-06-21

Similar Documents

Publication Publication Date Title
ES8605513A1 (es) Un procedimiento para preparar derivados de piridina
RU92004336A (ru) Водорастворимые производные камптотецина, способ их получения, фармацевтическая композиция, способ ингибирования энзима топоизомеразы, промежуточные продукты
FI900613A0 (fi) Menetelmä farmakologisesti aktiivisten heterosyklisten yhdisteiden valmistamiseksi
LU91196I2 (fr) Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
HUT68856A (en) Acridine derivatives, pharmaceutical compositions comprising the same compouds as effective substances and a process for producing the compounds and the pharmaceutical compositions
MX9202142A (es) Nuevos derivados de urea, proceso para su preparacion, y composicion farmaceutica que los comprende.
DE68906183D1 (de) 2'-desoxy-5-fluoruridinderivate.
CA1272482C (en) QUINOLINECARBOXYLIC ACID DERIVATIVES
AR006619A1 (es) Derivados de aminopiridina, composicion farmaceutica que los contien, metodo para elaborar un medicamento, intermediario quimico para la produccionde dichos compuestos y procedimiento para preparar los derivados de aminopiridina
FR2592879B1 (fr) Nouveaux derives de la decahydroquinoleine, leur procede de preparation, les intermediaires de preparation, leur application a titre de medicaments et les compositions les renfermant
PT90912A (pt) Processo para a preparacao de derivados de tiofenol
NZ227400A (en) Thiol-ketone and thiol-aldehyde derivatives, intermediates thereof and pharmaceutical compositions
ES8500935A1 (es) Un procedimiento para preparar derivados de piridina.
SE8303913L (sv) Heterocykliska foreningar
ES2001944A6 (es) Procedimiento de obtencion de derivados de xantina con actividad broncodilatadora y antiasmatica.
ES8504768A1 (es) Un procedimiento para preparar derivados de pirimidona
ES8504771A1 (es) Un procedimiento para preparar derivados de piridina
JO1274B1 (en) Pyridine derivatives
DE3070032D1 (en) Aminoalkyl benzofuran derivatives, their production and compositions containing them
EA199900608A1 (ru) Новые ингибиторы фарнезилтрансферазы, способы их получения, содержащие их фармацевтические композиции и их применение для получения медикаментов
FI101071B (fi) Menetelmä terapeuttisesti käyttökelpoisten 3,4-dihydroisokinoliini-N-o ksidien valmistamiseksi
KR860004040A (ko) 3,4-디아졸 유도체의 제조방법
ES535795A0 (es) Un procedimiento para preparar nuevas 5-aminometil-imidazol-1-il-1,3-dialquil-1h-pirazol-4-il-aroil-metanonas
ES2076995T3 (es) Procedimiento para preparar derivados de carbamato de lankacidina.