ES8507531A1 - Un procedimiento para preparar espiro (benzofuran-2(3h), 1'cicloalcanos) sustituidos en posicion 2' - Google Patents

Un procedimiento para preparar espiro (benzofuran-2(3h), 1'cicloalcanos) sustituidos en posicion 2'

Info

Publication number
ES8507531A1
ES8507531A1 ES529361A ES529361A ES8507531A1 ES 8507531 A1 ES8507531 A1 ES 8507531A1 ES 529361 A ES529361 A ES 529361A ES 529361 A ES529361 A ES 529361A ES 8507531 A1 ES8507531 A1 ES 8507531A1
Authority
ES
Spain
Prior art keywords
medicaments
compounds
substituted
cycloalkanes
benzofuran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529361A
Other languages
English (en)
Other versions
ES529361A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/313,097 external-priority patent/US4404221A/en
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of ES8507531A1 publication Critical patent/ES8507531A1/es
Publication of ES529361A0 publication Critical patent/ES529361A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ESPIRO-BENZOFURAN-2(3H),1-CICLOALCANOS SUSTITUIDOS EN POSICION 2, QUE CORRESPONDEN A LA FORMULA ESTRUCTURAL (I), EN LA QUE X ES AMINO SUSTITUIDO CON ALCOHILO INFERIOR O NITRO; M ES 1, 2 O 3; N ES 0, 1 O 2; P ES 0, 1 O 2; Y R1 Y R2 SON CADA UNO DE ELLOS HIDROGENO O ALCOHILO INFERIOR, Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES.COMPRNDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE NITRA UN COMPUESTO DE FORMULA (I), EN LA QUE X ES HIDROGENO, PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LA QUE X ES -NO2; SEGUNDA, SE REDUCE EL COMPUESTO DE FORMULA (I) OBTENIDO ANTERIORMENTE PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LA QUE X ES -NH2; Y POR ULTIMO, OPCIONALMENTE SE HIDROGENA UN COMPUESTO DE FORMULA (I), EN LA QUE X ES -NO2, JUNTO CON FORMALDEHIDO Y EN PRESENCIA DE UN CATALIZADOR DE PALADIO, PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LA QUE X ES -N(CH3)2.DE APLICACION EN EL TRATAMIENTO DE LA DEPRESION EN LOS MAMIFEROS.
ES529361A 1981-10-19 1984-02-01 Un procedimiento para preparar espiro (benzofuran-2(3h), 1'cicloalcanos) sustituidos en posicion 2' Granted ES529361A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/313,097 US4404221A (en) 1981-10-19 1981-10-19 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and its pharmaceutical use
US06/416,446 US4517311A (en) 1981-10-19 1982-09-13 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their analgesic and anti-depressant compositions

Publications (2)

Publication Number Publication Date
ES8507531A1 true ES8507531A1 (es) 1985-09-01
ES529361A0 ES529361A0 (es) 1985-09-01

Family

ID=26978681

Family Applications (3)

Application Number Title Priority Date Filing Date
ES516610A Expired ES8404341A1 (es) 1981-10-19 1982-10-18 "un procedimiento para preparar espiro benzofuran-2(3h), 1- cicloalcanos sustituidos en posicion 2".
ES529361A Granted ES529361A0 (es) 1981-10-19 1984-02-01 Un procedimiento para preparar espiro (benzofuran-2(3h), 1'cicloalcanos) sustituidos en posicion 2'
ES529362A Granted ES529362A0 (es) 1981-10-19 1984-02-01 Un procedimiento para preparar espiro (benzofuran-2(3h), 1'-cicloalcanos) sustituidos en posicion 2'

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES516610A Expired ES8404341A1 (es) 1981-10-19 1982-10-18 "un procedimiento para preparar espiro benzofuran-2(3h), 1- cicloalcanos sustituidos en posicion 2".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES529362A Granted ES529362A0 (es) 1981-10-19 1984-02-01 Un procedimiento para preparar espiro (benzofuran-2(3h), 1'-cicloalcanos) sustituidos en posicion 2'

Country Status (7)

Country Link
US (1) US4517311A (es)
EP (1) EP0077536B1 (es)
KR (1) KR880001814B1 (es)
AU (1) AU564232B2 (es)
DE (1) DE3272035D1 (es)
ES (3) ES8404341A1 (es)
IL (1) IL67011A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910323A (en) * 1981-10-19 1990-03-20 Hoechst Roussel Pharmaceuticals, Inc. 2'-substituted-spiro(benzofuran-2(3H),1'-cyclohexanes) and intermediates thereof
US4623657A (en) 1985-09-05 1986-11-18 Hoechst-Roussel Pharmaceuticals Inc. Spiro [benzofuran-2(3H),1'-cycloheptane]s and their therapeutic use
US5173499A (en) * 1988-04-15 1992-12-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
US5506247A (en) * 1988-04-15 1996-04-09 T Cell Sciences, Inc. Compounds that inhibit complement and/or suppress immune activity
US5366986A (en) * 1988-04-15 1994-11-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB913535A (en) * 1960-05-16 1962-12-19 Ici Ltd Coumaran derivatives
SE7308238L (es) * 1973-06-15 1974-12-13 Sandoz Ag
US3959475A (en) * 1973-12-12 1976-05-25 American Hoechst Corporation Substituted 1,3-dihydrospiro(isobenzofuran)s
US4166119A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4166120A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4263317A (en) * 1979-09-06 1981-04-21 Hoechst-Roussel Pharmaceuticals, Inc. Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s
US4404221A (en) * 1981-10-19 1983-09-13 Hoechst-Roussel Pharmaceuticals Inc. 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and its pharmaceutical use

Also Published As

Publication number Publication date
IL67011A (en) 1988-07-31
AU8944082A (en) 1983-04-28
US4517311A (en) 1985-05-14
ES8506688A1 (es) 1985-07-16
DE3272035D1 (en) 1986-08-21
KR840001967A (ko) 1984-06-07
EP0077536B1 (en) 1986-07-16
ES516610A0 (es) 1984-04-16
ES529362A0 (es) 1985-07-16
ES8404341A1 (es) 1984-04-16
EP0077536A3 (en) 1983-08-03
ES529361A0 (es) 1985-09-01
IL67011A0 (en) 1983-02-23
AU564232B2 (en) 1987-08-06
EP0077536A2 (en) 1983-04-27
KR880001814B1 (ko) 1988-09-19

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506