ES8506630A1 - Procedimiento para la preparacion de esteres de acido 6-metil-nicotinico - Google Patents

Procedimiento para la preparacion de esteres de acido 6-metil-nicotinico

Info

Publication number
ES8506630A1
ES8506630A1 ES531095A ES531095A ES8506630A1 ES 8506630 A1 ES8506630 A1 ES 8506630A1 ES 531095 A ES531095 A ES 531095A ES 531095 A ES531095 A ES 531095A ES 8506630 A1 ES8506630 A1 ES 8506630A1
Authority
ES
Spain
Prior art keywords
methyl
mixture
nitric acid
reaction mixture
heated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531095A
Other languages
English (en)
Other versions
ES531095A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of ES531095A0 publication Critical patent/ES531095A0/es
Publication of ES8506630A1 publication Critical patent/ES8506630A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ESTERES DE ACIDO 6-METIL-NICOTINICO.CONSISTE EN MEZCLAR 2-METIL-5-ETIL-PIRIDINA, ENFRIADO, CON POR LO MENOS LA CANTIDAD EQUIMOLAR DE ACIDO SULFURICO; CALENTAR LA MEZCLA A TEMPERATURA ENTRE 140 A 225JC; AN/ADIR A LA MEZCLA CALENTADA 3 MOLES DE ACIDO NITRICO POR CADA MOL DE EDUCTO, DE MANERA TAL QUE CONSTANTEMENTE SE SEPAREN POR DESTILACION AGUA Y/O ACIDO NITRICO DILUIDO; PROSEGUIR LA SEPARACION POR DESTILACION TRAS LA ADICION DE LA CANTIDAD DE ACIDO NITRICO NECESITADA PARA LA OXIDACION TODAVIA HASTA TANTO QUE SE HAYAN ELIMINADO TODO EL AGUA Y TODO EL ACIDO NITRICO; MEZCLAR LA MEZCLA DE REACCION CON UN ALCOHOL Y CALENTAR HASTA QUE ESTEN ESTERIFICADOS LOS ACIDOS CONTENIDOS EN LA MEZCLA DE REACCION Y; AISLAR EL ACIDO 6-METIL-NICOTICO A PARTIR DE LA MEZCLA DE ESTERES.
ES531095A 1983-05-10 1984-03-29 Procedimiento para la preparacion de esteres de acido 6-metil-nicotinico Expired ES8506630A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2542/83A CH654577A5 (de) 1983-05-10 1983-05-10 Verfahren zur herstellung von 6-methylnikotinsaeureester.

Publications (2)

Publication Number Publication Date
ES531095A0 ES531095A0 (es) 1985-07-16
ES8506630A1 true ES8506630A1 (es) 1985-07-16

Family

ID=4236137

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531095A Expired ES8506630A1 (es) 1983-05-10 1984-03-29 Procedimiento para la preparacion de esteres de acido 6-metil-nicotinico

Country Status (9)

Country Link
US (1) US4579953A (es)
EP (1) EP0128279B1 (es)
JP (1) JPS59206354A (es)
CA (1) CA1237434A (es)
CH (1) CH654577A5 (es)
DE (1) DE3476384D1 (es)
ES (1) ES8506630A1 (es)
IE (1) IE57120B1 (es)
MX (1) MX156101A (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH665838A5 (de) * 1985-06-20 1988-06-15 Lonza Ag 3-hydroxy-3-(2-methyl-5-pyridyl)-propionsaeurealkylester, ihre herstellung und verwendung.
CN112824387B (zh) * 2019-11-21 2023-03-21 济南尚博生物科技有限公司 一种2-甲基烟酸酯及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2522163A (en) * 1950-09-12 Process of manufacturing
US2475969A (en) * 1945-03-22 1949-07-12 Allied Chem & Dye Corp Oxidation of heterocyclic aromatic nitrogen compounds
US2694070A (en) * 1952-03-26 1954-11-09 Allied Chem & Dye Corp Process for preparing pyridine carboxylic acids
US2749350A (en) * 1953-03-30 1956-06-05 Phillips Petroleum Co Selective oxidation of nitrogen-containing heterocyclic compounds
US2993904A (en) * 1957-02-06 1961-07-25 Phillips Petroleum Co Preparation of 6-methylnicotinic acid
US2991285A (en) * 1958-09-09 1961-07-04 Rohm & Haas Process of cyanation and nitriles produced thereby

Also Published As

Publication number Publication date
JPH0475230B2 (es) 1992-11-30
JPS59206354A (ja) 1984-11-22
MX156101A (es) 1988-07-08
US4579953A (en) 1986-04-01
CA1237434A (en) 1988-05-31
ES531095A0 (es) 1985-07-16
DE3476384D1 (en) 1989-03-02
CH654577A5 (de) 1986-02-28
EP0128279A2 (de) 1984-12-19
EP0128279A3 (en) 1985-11-06
IE840749L (en) 1984-11-10
IE57120B1 (en) 1992-05-06
EP0128279B1 (de) 1989-01-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20011110