ES8505546A1 - Un metodo para preparar una solucion acuosa estable que contiene factor de necrosis de tumores. - Google Patents
Un metodo para preparar una solucion acuosa estable que contiene factor de necrosis de tumores.Info
- Publication number
- ES8505546A1 ES8505546A1 ES521266A ES521266A ES8505546A1 ES 8505546 A1 ES8505546 A1 ES 8505546A1 ES 521266 A ES521266 A ES 521266A ES 521266 A ES521266 A ES 521266A ES 8505546 A1 ES8505546 A1 ES 8505546A1
- Authority
- ES
- Spain
- Prior art keywords
- aqueous solution
- factor
- powder containing
- tumor necrosis
- stable aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
UN METODO PARA PREPARAR UNA SOLUCION ACUOSA ESTABLE QUE CONTIENE FACTOR DE NECROSIS DE TUMORES (FNT).COMPRENDE AN/ADIR AL MENOS UN MIEMBRO SELECCIONADO DEL GRUPO CONSTITUIDO POR UNA ALBUMINA, UNA GELATINA, UNA GLOBULINA, UNA PROTAMINA Y UNA SAL DE PROTAMINA A UNA SOLUCION ACUOSA DE POLVO QUE CONTIENE FNT. LA SOLUCION ACUOSA QUE CONTIENE FNT PUEDE ALMACENARSE DURANTE UN PERIODO PROLONGADO DE TIEMPO SIN PERDER SU ACTIVIDAD Y ES ESTABLE FRENTE A LA CONGELACION, DESCONGELACION, LIOFILIZACION, ETC.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57056690A JPS58174330A (ja) | 1982-04-07 | 1982-04-07 | ガン壊死因子の安定化法 |
JP57129560A JPS5920225A (ja) | 1982-07-27 | 1982-07-27 | ガン壊死因子の安定化方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8505546A1 true ES8505546A1 (es) | 1985-06-01 |
ES521266A0 ES521266A0 (es) | 1985-06-01 |
Family
ID=26397663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES521266A Granted ES521266A0 (es) | 1982-04-07 | 1983-04-06 | Un metodo para preparar una solucion acuosa estable que contiene factor de necrosis de tumores. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4447355A (es) |
EP (1) | EP0091258B2 (es) |
KR (1) | KR860000842B1 (es) |
CA (1) | CA1187412A (es) |
CH (1) | CH656534A5 (es) |
DE (1) | DE3373628D1 (es) |
ES (1) | ES521266A0 (es) |
FR (1) | FR2530472B1 (es) |
HU (1) | HU189251B (es) |
IT (1) | IT1162845B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6019719A (ja) * | 1983-07-15 | 1985-01-31 | Asahi Chem Ind Co Ltd | 抗腫瘍活性を有する蛋白質 |
US4524026A (en) * | 1983-08-29 | 1985-06-18 | Yoshio Sakagami | Novel proteinous cancer-cell proliferation inhibitory factors |
US4879226A (en) * | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
DE3583880D1 (de) * | 1984-04-09 | 1991-10-02 | Takeda Chemical Industries Ltd | Stabile interleukin-2-zusammensetzung. |
JPS60260522A (ja) | 1984-06-07 | 1985-12-23 | Asahi Chem Ind Co Ltd | 遺伝子組換体が生産する生理活性物質の安定化法 |
US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
US6686455B1 (en) | 1984-07-05 | 2004-02-03 | Genentech, Inc. | Tumor necrosis factor |
US5840522A (en) * | 1984-09-20 | 1998-11-24 | Chiron Corporation | Recombinant lectins |
US4677063A (en) * | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
US4677064A (en) * | 1984-11-09 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
EP0216934A4 (en) * | 1985-03-04 | 1987-07-09 | Sawai Seiyaku Kk | NOVEL SUBSTANCE INDUCING TUMOR NECROSIC FACTOR FROM ACID RESISTANT BACTERIA. |
US6084073A (en) * | 1985-03-25 | 2000-07-04 | Chiron Corporation | Recombinant ricin toxin |
US4770995A (en) * | 1985-08-29 | 1988-09-13 | New York Blood Center, Inc | Detection of the sensitivity of cells to the effects of tumor necrosis factor and lymphotoxin |
US4870163A (en) * | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
US5425940A (en) * | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
DE3631413A1 (de) * | 1986-09-16 | 1988-03-24 | Knoll Ag | Therapeutisches system zur lokalen applikation von pharmawirkstoffen |
US5215743A (en) * | 1988-04-13 | 1993-06-01 | Maninder Singh | Tumor necrosis factor formulations |
DE3839639A1 (de) * | 1988-11-24 | 1990-05-31 | Basf Ag | Verwendung von tnf bei der behandlung von hautkrankheiten |
US5223395A (en) * | 1988-12-01 | 1993-06-29 | Centocor, Inc. | Immunometric assays for tumor necrosis factor-alpha and methods for preventing the loss of biological activity of tumor necrosis factor-alpha in biological samples |
US5653974A (en) * | 1990-10-18 | 1997-08-05 | Board Of Regents,The University Of Texas System | Preparation and characterization of liposomal formulations of tumor necrosis factor |
EP0495187B1 (en) * | 1991-01-15 | 1997-01-22 | Hemosphere, Inc. | Protein nanomatrixes and method of production |
US5344644A (en) * | 1991-08-01 | 1994-09-06 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release |
DE4239877C1 (de) * | 1992-11-27 | 1994-03-17 | Boehringer Ingelheim Int | Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung |
JPH0776527A (ja) * | 1993-06-28 | 1995-03-20 | Hayashibara Biochem Lab Inc | 半固形製剤とその製造方法 |
US5556771A (en) * | 1995-02-10 | 1996-09-17 | Gen-Probe Incorporated | Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification |
ES2180416B1 (es) | 2001-03-12 | 2004-06-01 | BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A. | Procedimiento para la preparacion de mezclas de reaccion estabilizadas, total o parcialmente desecadas, que comprenden, al menos, una enzima, mezclas de reaccion y kits que las contienen. |
RU2377253C2 (ru) * | 2002-12-02 | 2009-12-27 | Амген Фремонт,Инк. | Антитела, специфичные к фактору некроза опухолей, и их применение |
JP2010143860A (ja) * | 2008-12-19 | 2010-07-01 | Chisso Corp | タンパク質の安定化剤 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3637640A (en) * | 1970-05-04 | 1972-01-25 | Diagnostic Data Inc | Orgotein stabilized with saccharide process and products |
JPS5668607A (en) * | 1979-11-07 | 1981-06-09 | Teikoku Hormone Mfg Co Ltd | Medical preparation with storage stability |
-
1983
- 1983-03-23 US US06/477,866 patent/US4447355A/en not_active Expired - Lifetime
- 1983-03-23 HU HU83981A patent/HU189251B/hu unknown
- 1983-03-28 DE DE8383301740T patent/DE3373628D1/de not_active Expired
- 1983-03-28 EP EP83301740A patent/EP0091258B2/en not_active Expired
- 1983-03-29 CA CA000424749A patent/CA1187412A/en not_active Expired
- 1983-04-05 IT IT67372/83A patent/IT1162845B/it active
- 1983-04-05 FR FR8305540A patent/FR2530472B1/fr not_active Expired
- 1983-04-06 ES ES521266A patent/ES521266A0/es active Granted
- 1983-04-06 KR KR1019830001415A patent/KR860000842B1/ko not_active IP Right Cessation
- 1983-04-07 CH CH1885/83A patent/CH656534A5/fr not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0091258B1 (en) | 1987-09-16 |
KR860000842B1 (ko) | 1986-07-09 |
HU189251B (en) | 1986-06-30 |
IT1162845B (it) | 1987-04-01 |
EP0091258A3 (en) | 1984-09-19 |
US4447355A (en) | 1984-05-08 |
FR2530472A1 (fr) | 1984-01-27 |
CA1187412A (en) | 1985-05-21 |
KR840004365A (ko) | 1984-10-15 |
FR2530472B1 (fr) | 1986-04-25 |
IT8367372A0 (it) | 1983-04-05 |
EP0091258B2 (en) | 1992-12-16 |
ES521266A0 (es) | 1985-06-01 |
DE3373628D1 (en) | 1987-10-22 |
EP0091258A2 (en) | 1983-10-12 |
CH656534A5 (fr) | 1986-07-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC2A | Transfer of patent |
Free format text: DAINIPPON PHARMACEUTICAL CO, LTD.(TITULAR AL 50%) |