ES8505330A1 - Derivados de acido pentanodioico. - Google Patents

Derivados de acido pentanodioico.

Info

Publication number
ES8505330A1
ES8505330A1 ES520799A ES520799A ES8505330A1 ES 8505330 A1 ES8505330 A1 ES 8505330A1 ES 520799 A ES520799 A ES 520799A ES 520799 A ES520799 A ES 520799A ES 8505330 A1 ES8505330 A1 ES 8505330A1
Authority
ES
Spain
Prior art keywords
beta
acid derivatives
pentanedioic acid
hydroxy
inhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520799A
Other languages
English (en)
Other versions
ES520799A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES520799A0 publication Critical patent/ES520799A0/es
Publication of ES8505330A1 publication Critical patent/ES8505330A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/305—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • C07C59/31—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/18—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part
    • C07C33/20—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/26—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/29—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ACIDO PENTANODIOICO.CONSISTE EN OZONOLIZAR EL BIS-ALILCARBINOL DE FORMULA (II) POR TRATAMIENTO CON OZONO, A UNA TEMPERATURA DE C60 A 30JC PARA FORMAR EL DERIVADO DE FORMULA (III), EL CUAL SE ESTERIFICA AL ACIDO PENTANODIOICO DE FORMULA (I), DONDE R1 Y R2 SON H, ALQUILO C 1 A 6; R3, R4 Y R5 SON H, ALQUILO C 1 A 6, CICLOALQUILO C 3 A 10 Y OTROS; M ES 0 A 15; N ES 0 A 15; X ES -CH2- Y -O-, ALQUILENO C 2 A 15 Y OTROS.TIENEN UTILIDAD PARA INHIBIR LA FORMACION DE COLESTEROL EN SUERO.
ES520799A 1982-03-22 1983-03-21 Derivados de acido pentanodioico. Expired ES8505330A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36054382A 1982-03-22 1982-03-22

Publications (2)

Publication Number Publication Date
ES520799A0 ES520799A0 (es) 1985-05-16
ES8505330A1 true ES8505330A1 (es) 1985-05-16

Family

ID=23418429

Family Applications (1)

Application Number Title Priority Date Filing Date
ES520799A Expired ES8505330A1 (es) 1982-03-22 1983-03-21 Derivados de acido pentanodioico.

Country Status (12)

Country Link
EP (1) EP0089674B1 (es)
JP (1) JPS58172341A (es)
AU (1) AU564466B2 (es)
CA (1) CA1249268A (es)
DE (1) DE3361607D1 (es)
DK (1) DK162713C (es)
ES (1) ES8505330A1 (es)
IE (1) IE54626B1 (es)
NO (1) NO158416C (es)
NZ (1) NZ203637A (es)
PT (1) PT76419B (es)
ZA (1) ZA831983B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554359A (en) * 1984-01-09 1985-11-19 G. D. Searle & Co. 3-Substituted pentanedioic acids and derivatives thereof
US5055613A (en) * 1988-02-18 1991-10-08 G. D. Searle & Co. Metabolites of pentanedioic acid derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112249A (en) * 1962-12-10 1963-11-26 Commw Engineering Co Of Ohio Process of splitting steroids
US3629449A (en) * 1968-04-22 1971-12-21 Majid Siddiqi Process of combatting hypercholesterolemia
US3818080A (en) * 1972-07-20 1974-06-18 Searle & Co 3-hydroxy-3-substituted glutaric acid derivatives
FR2244485A1 (en) * 1973-08-06 1975-04-18 Aries Robert Lithium dicarboxylic acid salts - in compositions for treatment of psychoses, esp. manic depression

Also Published As

Publication number Publication date
DK162713B (da) 1991-12-02
DK125483D0 (da) 1983-03-18
AU1261783A (en) 1983-09-29
ES520799A0 (es) 1985-05-16
IE54626B1 (en) 1989-12-20
AU564466B2 (en) 1987-08-13
EP0089674A1 (en) 1983-09-28
DK162713C (da) 1992-04-21
PT76419A (en) 1983-04-01
JPH0525866B2 (es) 1993-04-14
CA1249268A (en) 1989-01-24
PT76419B (en) 1985-12-09
DE3361607D1 (de) 1986-02-06
NZ203637A (en) 1986-08-08
ZA831983B (en) 1984-11-28
NO158416B (no) 1988-05-30
IE830604L (en) 1983-09-22
NO158416C (no) 1988-09-07
NO830981L (no) 1983-09-23
JPS58172341A (ja) 1983-10-11
EP0089674B1 (en) 1985-12-27
DK125483A (da) 1983-09-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401