ES8502992A1 - Ergot alkaloids - Google Patents
Ergot alkaloidsInfo
- Publication number
- ES8502992A1 ES8502992A1 ES524815A ES524815A ES8502992A1 ES 8502992 A1 ES8502992 A1 ES 8502992A1 ES 524815 A ES524815 A ES 524815A ES 524815 A ES524815 A ES 524815A ES 8502992 A1 ES8502992 A1 ES 8502992A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- agents
- ergot alkaloids
- phenyl
- lysergyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
2-methyl-lysergyl ethers and thioethers are useful neuroleptics, anti-migraine agents, cerebral insufficiency agents, agents for senile dementia and anti-depressants. Preferably compounds of formula < IMAGE > where X is O or S, R1 is H, C1-4 alkyl or phenyl, R2 is C1-3 alkyl and R3 is phenyl or pyridyl, which may be substituted, or alkyl are used.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH4772/82A CH649998A5 (en) | 1982-08-09 | 1982-08-09 | ERGOL DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND HEALING AGENTS, CONTAINING THESE ERGOL DERIVATIVES AS AN ACTIVE SUBSTANCE. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8502992A1 true ES8502992A1 (en) | 1985-02-01 |
| ES524815A0 ES524815A0 (en) | 1985-02-01 |
Family
ID=4282273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES524815A Granted ES524815A0 (en) | 1982-08-09 | 1983-08-08 | PROCEDURE FOR THE PREPARATION OF A (TIO) -ETER OF 2-METHYL-LISERG-8-ILO |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS5948480A (en) |
| AT (1) | AT383125B (en) |
| AU (1) | AU563736B2 (en) |
| BE (1) | BE897473A (en) |
| CA (1) | CA1215972A (en) |
| CH (1) | CH649998A5 (en) |
| DE (1) | DE3327705A1 (en) |
| DK (1) | DK361983A (en) |
| ES (1) | ES524815A0 (en) |
| FI (1) | FI73679C (en) |
| FR (1) | FR2531433B1 (en) |
| GB (1) | GB2125041B (en) |
| GR (1) | GR78923B (en) |
| HU (1) | HU187600B (en) |
| IL (1) | IL69450A (en) |
| IT (1) | IT1168961B (en) |
| MY (1) | MY8700166A (en) |
| NL (1) | NL8302776A (en) |
| NZ (1) | NZ205181A (en) |
| PH (1) | PH20385A (en) |
| PT (1) | PT77168B (en) |
| SE (1) | SE8304315L (en) |
| ZA (1) | ZA835850B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675322A (en) * | 1984-12-10 | 1987-06-23 | Eli Lilly And Company | 1-Substituted-6-n-propyl-8β-methylthio-methylergolines |
| HU193782B (en) * | 1985-06-21 | 1987-11-30 | Richter Gedeon Vegyeszet | Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof |
| FR2589734B1 (en) * | 1985-11-13 | 1988-09-02 | Roussel Uclaf | USE OF ERGOLIN DERIVATIVES FOR OBTAINING A GERIATRIC MEDICINE |
| US4798834A (en) * | 1987-08-31 | 1989-01-17 | Eli Lilly And Company | Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement |
| DE3913756A1 (en) * | 1989-04-21 | 1990-10-25 | Schering Ag | 8 (BETA) SUBSTITUTED ERGOLINE, METHOD FOR THE PRODUCTION AND USE THEREOF |
| DE10212564B4 (en) * | 2002-03-12 | 2007-04-19 | Neurobiotec Gmbh | 1-Allyl ergot alkaloid derivatives and their use for the prophylaxis and treatment of migraine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE41533B1 (en) * | 1974-03-14 | 1980-01-30 | Sandoz Ltd | Thiomethyl ergolene derivatives |
| US3901894A (en) * | 1974-06-06 | 1975-08-26 | Lilly Co Eli | 8-thiomethylergolines |
| US3959288A (en) * | 1974-12-13 | 1976-05-25 | Eli Lilly And Company | 8-Oxymethylergolines and process therefor |
| US4166182A (en) * | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
| US4382940A (en) * | 1979-12-06 | 1983-05-10 | Farmitalia Carlo Erba S.P.A. | Ercoline derivatives and therapeutic compositions having CNS affecting activity |
-
1982
- 1982-08-09 CH CH4772/82A patent/CH649998A5/en not_active IP Right Cessation
-
1983
- 1983-08-01 DE DE19833327705 patent/DE3327705A1/en not_active Withdrawn
- 1983-08-02 FI FI832789A patent/FI73679C/en not_active IP Right Cessation
- 1983-08-04 FR FR8313018A patent/FR2531433B1/en not_active Expired
- 1983-08-05 GB GB08321222A patent/GB2125041B/en not_active Expired
- 1983-08-05 NL NL8302776A patent/NL8302776A/en not_active Application Discontinuation
- 1983-08-05 BE BE1/10847A patent/BE897473A/en not_active IP Right Cessation
- 1983-08-08 JP JP58144843A patent/JPS5948480A/en active Pending
- 1983-08-08 DK DK361983A patent/DK361983A/en unknown
- 1983-08-08 IL IL69450A patent/IL69450A/en unknown
- 1983-08-08 NZ NZ205181A patent/NZ205181A/en unknown
- 1983-08-08 HU HU832798A patent/HU187600B/en unknown
- 1983-08-08 GR GR72165A patent/GR78923B/el unknown
- 1983-08-08 AT AT0286383A patent/AT383125B/en not_active IP Right Cessation
- 1983-08-08 ES ES524815A patent/ES524815A0/en active Granted
- 1983-08-08 PT PT77168A patent/PT77168B/en unknown
- 1983-08-08 SE SE8304315A patent/SE8304315L/en not_active Application Discontinuation
- 1983-08-08 CA CA000434064A patent/CA1215972A/en not_active Expired
- 1983-08-08 AU AU17672/83A patent/AU563736B2/en not_active Expired - Fee Related
- 1983-08-09 IT IT22490/83A patent/IT1168961B/en active
- 1983-08-09 ZA ZA835850A patent/ZA835850B/en unknown
- 1983-08-09 PH PH29378A patent/PH20385A/en unknown
-
1987
- 1987-12-30 MY MY166/87A patent/MY8700166A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA835850B (en) | 1985-03-27 |
| CA1215972A (en) | 1986-12-30 |
| JPS5948480A (en) | 1984-03-19 |
| AT383125B (en) | 1987-05-25 |
| FI832789A0 (en) | 1983-08-02 |
| GB2125041A (en) | 1984-02-29 |
| FR2531433B1 (en) | 1985-10-18 |
| IL69450A (en) | 1986-10-31 |
| HU187600B (en) | 1986-01-28 |
| SE8304315D0 (en) | 1983-08-08 |
| AU1767283A (en) | 1984-02-16 |
| PH20385A (en) | 1986-12-08 |
| IT8322490A0 (en) | 1983-08-09 |
| DE3327705A1 (en) | 1984-02-09 |
| PT77168B (en) | 1986-03-27 |
| CH649998A5 (en) | 1985-06-28 |
| BE897473A (en) | 1984-02-06 |
| GB8321222D0 (en) | 1983-09-07 |
| MY8700166A (en) | 1987-12-31 |
| DK361983A (en) | 1984-02-10 |
| IL69450A0 (en) | 1983-11-30 |
| FR2531433A1 (en) | 1984-02-10 |
| ATA286383A (en) | 1986-10-15 |
| ES524815A0 (en) | 1985-02-01 |
| AU563736B2 (en) | 1987-07-23 |
| SE8304315L (en) | 1984-02-10 |
| FI73679C (en) | 1987-11-09 |
| FI73679B (en) | 1987-07-31 |
| GB2125041B (en) | 1986-04-23 |
| NZ205181A (en) | 1986-07-11 |
| DK361983D0 (en) | 1983-08-08 |
| FI832789A (en) | 1984-02-10 |
| GR78923B (en) | 1984-10-02 |
| NL8302776A (en) | 1984-03-01 |
| IT1168961B (en) | 1987-05-20 |
| PT77168A (en) | 1983-09-01 |
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