ES8502108A1 - Procedimiento para la obtencion de derivados de tetrahidrocarbazol - Google Patents

Procedimiento para la obtencion de derivados de tetrahidrocarbazol

Info

Publication number
ES8502108A1
ES8502108A1 ES528654A ES528654A ES8502108A1 ES 8502108 A1 ES8502108 A1 ES 8502108A1 ES 528654 A ES528654 A ES 528654A ES 528654 A ES528654 A ES 528654A ES 8502108 A1 ES8502108 A1 ES 8502108A1
Authority
ES
Spain
Prior art keywords
alkyl
radical
derivatives
twice
substituted once
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528654A
Other languages
English (en)
Other versions
ES528654A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19833300094 external-priority patent/DE3300094A1/de
Priority claimed from DE19833336643 external-priority patent/DE3336643A1/de
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES8502108A1 publication Critical patent/ES8502108A1/es
Publication of ES528654A0 publication Critical patent/ES528654A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE TETRAHIDROCARBAZOL.CONSISTE EN HACER REACCIONAR COMPUESTOS DE FORMULA (II) EN UN MEDIO DISOCIADOR (HE) Y ELIMINAR (HE) CON BASES ORGANICAS E INORGANICAS COMO BASES ALCALINAS Y AMINAS, A UNA TEMPERATURA ENTRE 50J Y 200JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y LAS SALES FISIOLOGICAMENTE ACEPTABLES. DONDE: THC SIGNIFICA UN RESTO 1,2,3,4-TETRAHIDROCARBAZOL-1-3-ILO, UNA O DOS VECES SUSTITUIDO POR ALQUILO Y OTROS; Z SIGNIFICA AR Y H; AR SIGNIFICA UN FENILO INSUSTITUIDO UNA O DOS VECES SUSTITUIDO POR ALQUILO Y OTROS; X SIGNIFICA HAL U OH; E UNO SIGNIFICA X, CN O NH2 Y EL OTRO H; Y SIGNIFICAN JUNTOS UN DOBLE ENLACE CFC; Y A SIGNIFICA -CH2- O -CH2-CH2-.SE UTILIZAN COMO MEDICAMENTOS PARA EL SISTEMA CENTRAL.
ES528654A 1983-01-04 1984-01-03 Procedimiento para la obtencion de derivados de tetrahidrocarbazol Granted ES528654A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833300094 DE3300094A1 (de) 1983-01-04 1983-01-04 Tetrahydrocarbazolderivate
DE19833336643 DE3336643A1 (de) 1983-10-08 1983-10-08 Tetrahydrocarbazolderivate

Publications (2)

Publication Number Publication Date
ES8502108A1 true ES8502108A1 (es) 1984-12-16
ES528654A0 ES528654A0 (es) 1984-12-16

Family

ID=25807401

Family Applications (1)

Application Number Title Priority Date Filing Date
ES528654A Granted ES528654A0 (es) 1983-01-04 1984-01-03 Procedimiento para la obtencion de derivados de tetrahidrocarbazol

Country Status (8)

Country Link
US (3) US4547576A (es)
EP (1) EP0115607A1 (es)
AU (1) AU566688B2 (es)
CA (1) CA1259618A (es)
ES (1) ES528654A0 (es)
FI (1) FI840012A (es)
HU (1) HU192863B (es)
IL (1) IL70611A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518745D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB9113802D0 (en) * 1991-06-26 1991-08-14 Smithkline Beecham Plc Medicaments
DE10164564B4 (de) * 2001-12-14 2007-05-16 Zentaris Gmbh Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR)
BR0316521A (pt) * 2002-11-26 2005-10-04 Pfizer Prod Inc Ativadores de ppar
US7332520B2 (en) * 2003-06-06 2008-02-19 Merck & Co., Inc. Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
AU2006214233A1 (en) * 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
WO2013130744A1 (en) 2012-02-28 2013-09-06 Wayne State University Using ion current signal for engine performance and emissions measuring techniques and methods for doing the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
US3634420A (en) * 1969-05-09 1972-01-11 American Cyanamid Co 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
GB1260768A (en) * 1969-08-28 1972-01-19 Pfizer N-alkyl-tetrahydrocarbazoles
CH586678A5 (es) * 1970-05-25 1977-04-15 Hoffmann La Roche
EP0077607A1 (en) * 1981-09-17 1983-04-27 Beecham Group Plc N-substituted 3-aryl piperidines and derivatives thereof

Also Published As

Publication number Publication date
US4698351A (en) 1987-10-06
AU2286483A (en) 1984-07-05
AU566688B2 (en) 1987-10-29
US4618614A (en) 1986-10-21
FI840012A (fi) 1984-07-05
HU192863B (en) 1987-07-28
ES528654A0 (es) 1984-12-16
US4547576A (en) 1985-10-15
CA1259618A (en) 1989-09-19
HUT34742A (en) 1985-04-28
IL70611A0 (en) 1984-04-30
FI840012A0 (fi) 1984-01-03
EP0115607A1 (de) 1984-08-15
IL70611A (en) 1987-03-31

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