ES8501392A1 - Procedimiento para la obtencion de derivados de indol conteniendo azufre - Google Patents
Procedimiento para la obtencion de derivados de indol conteniendo azufreInfo
- Publication number
- ES8501392A1 ES8501392A1 ES526121A ES526121A ES8501392A1 ES 8501392 A1 ES8501392 A1 ES 8501392A1 ES 526121 A ES526121 A ES 526121A ES 526121 A ES526121 A ES 526121A ES 8501392 A1 ES8501392 A1 ES 8501392A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- indole derivatives
- sulphuric
- twice
- substituted once
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE INDOL CONTENIENDO AZUFRE.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), PARA OBTENER UN INDOL DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE ACEPTABLES. DONDE: IND SIGNIFICA UN RESTO INDOL-3-ILO QUE PUEDE ESTAR UNA O DOS VECES SUSTITUIDO POR ALQUILO, OH, HALOGENO Y OTROS; A SIGNIFICA UN RADICAL DE FORMULA (IV) O DE FORMULA (V); N SIGNIFICA 0 O 1; M ES 2, 3 O 4; E SIGNIFICA S, SO O SO2; AR SIGNIFICA UN GRUPO FENILO INSUSTITUIDO O UNA O DOS VECES SUSTITUIDO POR ALQUILO, OH, HALOGENO Y OTROS; X1 SIGNIFICA X O NH2; X SIGNIFICA HALOGENO Y; X2 Y X3 SIGNIFICAN NH, SI X1 ES NH2. LA REACCION SE EFECTUA EN UN AUTOCLAVE, EN PRESENCIA DE DISOLVENTES, COMO BENCENO, ACETONA, ALCOHOLES Y OTROS Y A TEMPERATURA ENTRE 0J Y 158JC.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823236243 DE3236243A1 (de) | 1982-09-30 | 1982-09-30 | Schwefelhaltige indolderivate |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8501392A1 true ES8501392A1 (es) | 1984-11-16 |
ES526121A0 ES526121A0 (es) | 1984-11-16 |
Family
ID=6174592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES526121A Granted ES526121A0 (es) | 1982-09-30 | 1983-09-29 | Procedimiento para la obtencion de derivados de indol conteniendo azufre |
Country Status (14)
Country | Link |
---|---|
US (1) | US4617309A (es) |
EP (1) | EP0105397B1 (es) |
JP (1) | JPS5982384A (es) |
AT (1) | ATE20747T1 (es) |
AU (1) | AU564169B2 (es) |
CA (1) | CA1244831A (es) |
DE (2) | DE3236243A1 (es) |
ES (1) | ES526121A0 (es) |
HK (1) | HK28487A (es) |
HU (1) | HU192243B (es) |
IE (1) | IE56051B1 (es) |
IL (1) | IL69821A (es) |
SG (1) | SG94086G (es) |
ZA (1) | ZA837311B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3342632A1 (de) * | 1983-11-25 | 1985-06-05 | Merck Patent Gmbh, 6100 Darmstadt | Indolderivate |
US4704390A (en) * | 1986-02-13 | 1987-11-03 | Warner-Lambert Company | Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents |
DE3604949A1 (de) * | 1986-02-17 | 1987-08-20 | Merck Patent Gmbh | Hydroxyindolester |
DE3907974A1 (de) * | 1989-03-11 | 1990-09-13 | Merck Patent Gmbh | Indolderivate |
US5198443A (en) * | 1991-06-28 | 1993-03-30 | Warner-Lambert Company | Substituted 1,2,3,6-tetrahydropyridines as central nervous system agents |
US5120748A (en) * | 1991-06-28 | 1992-06-09 | Warner-Lambert Company | Substituted 1,2,3,6-tetrahydropyridines as central nervous system agents |
US5364767A (en) * | 1993-02-11 | 1994-11-15 | Research Organics, In. | Chromogenic compounds and methods of using same |
US7423176B2 (en) * | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
US7119214B2 (en) * | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
EP1589016A1 (en) * | 2004-04-13 | 2005-10-26 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
TW200734313A (en) | 2006-01-17 | 2007-09-16 | Astrazeneca Ab | Piperazines and piperidines as mGluR5 potentiators |
FR2932481B1 (fr) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique. |
FR2932482B1 (fr) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Nouveaux derives de (phenyl-3,6-dihydro-2h-pyridinyl)- (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
EP2606894A1 (en) | 2011-12-20 | 2013-06-26 | Sanofi | Novel therapeutic use of p75 receptor antagonists |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2580475A (en) * | 1947-10-30 | 1952-01-01 | Schering Corp | Imidazolinylalkyl ethers of pyridylcarbinols |
GB1189064A (en) * | 1967-05-01 | 1970-04-22 | Sterling Drug Inc | Indole Derivatives |
DE2060816C3 (de) * | 1970-12-10 | 1980-09-04 | Merck Patent Gmbh, 6100 Darmstadt | 4-Phenylpiperidinderivate Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen |
US4302589A (en) * | 1980-05-08 | 1981-11-24 | American Cyanamid Company | Cis-mono and disubstituted-2-methyl-3-[(piperazinyl) and (piperidino)ethyl]indolines, intermediates for their preparation and methods of preparation |
DE3034005C2 (de) * | 1980-09-10 | 1982-12-09 | A. Nattermann & Cie GmbH, 5000 Köln | Indolessigsäure-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen |
-
1982
- 1982-09-30 DE DE19823236243 patent/DE3236243A1/de not_active Withdrawn
-
1983
- 1983-09-19 EP EP83109244A patent/EP0105397B1/de not_active Expired
- 1983-09-19 DE DE8383109244T patent/DE3364527D1/de not_active Expired
- 1983-09-19 AT AT83109244T patent/ATE20747T1/de not_active IP Right Cessation
- 1983-09-26 IL IL69821A patent/IL69821A/xx unknown
- 1983-09-29 IE IE2311/83A patent/IE56051B1/xx unknown
- 1983-09-29 AU AU19777/83A patent/AU564169B2/en not_active Ceased
- 1983-09-29 ZA ZA837311A patent/ZA837311B/xx unknown
- 1983-09-29 ES ES526121A patent/ES526121A0/es active Granted
- 1983-09-30 JP JP58180893A patent/JPS5982384A/ja active Pending
- 1983-09-30 HU HU833413A patent/HU192243B/hu not_active IP Right Cessation
- 1983-09-30 CA CA000438072A patent/CA1244831A/en not_active Expired
- 1983-09-30 US US06/537,621 patent/US4617309A/en not_active Expired - Fee Related
-
1986
- 1986-12-11 SG SG940/86A patent/SG94086G/en unknown
-
1987
- 1987-04-09 HK HK284/87A patent/HK28487A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ATE20747T1 (de) | 1986-08-15 |
JPS5982384A (ja) | 1984-05-12 |
HU192243B (en) | 1987-05-28 |
HK28487A (en) | 1987-04-16 |
IL69821A (en) | 1986-09-30 |
AU564169B2 (en) | 1987-08-06 |
SG94086G (en) | 1989-01-27 |
IL69821A0 (en) | 1983-12-30 |
HUT34970A (en) | 1985-05-28 |
ZA837311B (en) | 1984-06-27 |
AU1977783A (en) | 1984-04-05 |
IE832311L (en) | 1984-03-30 |
ES526121A0 (es) | 1984-11-16 |
DE3236243A1 (de) | 1984-04-05 |
EP0105397B1 (de) | 1986-07-16 |
DE3364527D1 (de) | 1986-08-21 |
IE56051B1 (en) | 1991-03-27 |
US4617309A (en) | 1986-10-14 |
EP0105397A1 (de) | 1984-04-18 |
CA1244831A (en) | 1988-11-15 |
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