ES8501766A1 - Procedimiento de preparacion de nuevos derivados de tieno (2,3-b) pirrol. - Google Patents

Procedimiento de preparacion de nuevos derivados de tieno (2,3-b) pirrol.

Info

Publication number
ES8501766A1
ES8501766A1 ES528088A ES528088A ES8501766A1 ES 8501766 A1 ES8501766 A1 ES 8501766A1 ES 528088 A ES528088 A ES 528088A ES 528088 A ES528088 A ES 528088A ES 8501766 A1 ES8501766 A1 ES 8501766A1
Authority
ES
Spain
Prior art keywords
lower alkyl
thieno
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528088A
Other languages
English (en)
Other versions
ES528088A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of ES528088A0 publication Critical patent/ES528088A0/es
Publication of ES8501766A1 publication Critical patent/ES8501766A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS DE TIENO2,3-BPIRROL.CONSISTE EN: A) DEDIOZAR LOS DERIVADOS DIAZOICOS DE FORMULA (II), PARA OBTENER UN COMPUESTO DE FORMULA (III); B) ACILAR A (III) CON UN HALOGENURO DE ACILO DE FORMULA X-CO-R4, PARA OBTENER UN COMPUESTO DE FORMULA (IV); C) SAPONIFICAR A (IV) PARA OBTENER UN COMPUESTO DE FORMULA (V); D) DESCARBOXILAR A (V), PARA OBTENER UN COMPUESTO DE FORMULA (VI); Y E) N-ALCOILAR A (VI) POR MEDIO DE UN BAB-HALOGENO O DERIVADO DE FORMULA (VII), PARA OBTENER UN COMPUESTO DE FORMULA (I). DONDE X ES HAL; R1 ES H, O UN RADICAL ALCOILO DE C 1 A 5 DE CADENA LINEAL O RAMIFICADO; R2 ES UN RADICAL CIANO Y OTROS; R3 ES UN RADICAL ALCOILO DE CADENA LINEAL O RAMIFICADO DE C 1 A 5 Y R4 ES UN RADICAL ALCOILO EN CADENA LINEAL O RAMIFICADO DE C 1 A 5 Y OTROS.SE UTILIZAN EN EL TRATAMIENTO DE LOS DOLORES AGUDOS O CRONICOS.
ES528088A 1982-12-16 1983-12-15 Procedimiento de preparacion de nuevos derivados de tieno (2,3-b) pirrol. Expired ES8501766A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8221090A FR2537974A1 (fr) 1982-12-16 1982-12-16 Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
ES528088A0 ES528088A0 (es) 1984-12-16
ES8501766A1 true ES8501766A1 (es) 1984-12-16

Family

ID=9280166

Family Applications (1)

Application Number Title Priority Date Filing Date
ES528088A Expired ES8501766A1 (es) 1982-12-16 1983-12-15 Procedimiento de preparacion de nuevos derivados de tieno (2,3-b) pirrol.

Country Status (20)

Country Link
US (1) US4608384A (es)
EP (1) EP0114014B1 (es)
JP (1) JPS59118788A (es)
KR (1) KR840007004A (es)
AT (1) ATE27277T1 (es)
AU (1) AU2245883A (es)
CA (1) CA1212380A (es)
DD (1) DD259193A5 (es)
DE (1) DE3371632D1 (es)
DK (1) DK577483A (es)
ES (1) ES8501766A1 (es)
FR (1) FR2537974A1 (es)
GR (1) GR79477B (es)
IL (1) IL70457A (es)
MA (1) MA19977A1 (es)
NO (1) NO834637L (es)
OA (1) OA07612A (es)
PH (1) PH19425A (es)
PT (1) PT77826B (es)
ZA (1) ZA839341B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2554819B1 (fr) * 1983-11-10 1986-05-16 Adir Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant
JP3091297B2 (ja) * 1992-01-10 2000-09-25 住友製薬株式会社 ピロリジン誘導体およびその製造方法
FR2733750B1 (fr) * 1995-05-03 1997-06-13 Synthelabo Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique
GB9716657D0 (en) * 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9803226D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9803228D0 (en) * 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9902455D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902453D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902459D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902452D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB0000625D0 (en) 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds
AU2001280461A1 (en) * 2000-08-04 2002-02-18 Eli Lilly And Company Substituted pyrrole compounds and their use as spla2 inhibitors
US6730694B1 (en) * 2001-07-20 2004-05-04 Eli Lilly And Company sPLA2 inhibitors
JP2004035507A (ja) * 2002-07-05 2004-02-05 Nippon Soda Co Ltd ピロール誘導体及びその製造方法
US7196106B2 (en) * 2002-11-05 2007-03-27 Merck & Co., Inc Cyanothiophene derivatives, compositions containing such compounds and methods of use
DK1648904T3 (da) * 2003-07-31 2007-10-22 Wyeth Corp N-sulfonylheterocyclopyrrolalkylaminforbindelser som 5-hydroxytryptamin-6-ligander
WO2011100324A1 (en) * 2010-02-09 2011-08-18 Ironwood Pharmaceuticals Inc. Cannabinoid receptor agonists

Also Published As

Publication number Publication date
IL70457A (en) 1986-02-28
FR2537974A1 (fr) 1984-06-22
DD259193A5 (de) 1988-08-17
ZA839341B (en) 1984-07-25
ES528088A0 (es) 1984-12-16
US4608384A (en) 1986-08-26
EP0114014A2 (fr) 1984-07-25
OA07612A (fr) 1985-03-31
EP0114014B1 (fr) 1987-05-20
DK577483A (da) 1984-06-17
PH19425A (en) 1986-04-15
AU2245883A (en) 1984-06-21
MA19977A1 (fr) 1984-07-01
NO834637L (no) 1984-06-18
DE3371632D1 (en) 1987-06-25
EP0114014A3 (en) 1984-08-22
FR2537974B1 (es) 1985-03-15
ATE27277T1 (de) 1987-06-15
PT77826B (fr) 1986-05-05
CA1212380A (fr) 1986-10-07
GR79477B (es) 1984-10-30
DK577483D0 (da) 1983-12-15
KR840007004A (ko) 1984-12-04
IL70457A0 (en) 1984-03-30
PT77826A (fr) 1984-01-01
JPS59118788A (ja) 1984-07-09

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