ES8407018A1 - Synthesis of 1-(4-isopropylthiophenyl)-2-n- octylaminopropanol, ester and salt of same - Google Patents
Synthesis of 1-(4-isopropylthiophenyl)-2-n- octylaminopropanol, ester and salt of sameInfo
- Publication number
- ES8407018A1 ES8407018A1 ES522440A ES522440A ES8407018A1 ES 8407018 A1 ES8407018 A1 ES 8407018A1 ES 522440 A ES522440 A ES 522440A ES 522440 A ES522440 A ES 522440A ES 8407018 A1 ES8407018 A1 ES 8407018A1
- Authority
- ES
- Spain
- Prior art keywords
- synthesis
- octylaminopropanol
- isopropylthiophenyl
- ester
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
Abstract
PROCEDURE FOR THE SYNTHESIS OF 1- (4-ISOPROPILTIOFENIL) -2-N.OCTILAMINOPROPANOL. IT CONSISTS OF SOMETER 1- (4-TIOFENILO) -2-N.OCTALAMINOPROPANOL TO A PROCESS OF ALKYLATION, REACTIONING THIS WITH AN AGENT IC3H7X, TO OBTAIN COMPOUNDS FROM FORMULA (I), WHERE X REPRESENTS AN ELIMINABLE GROUP, WITH PROPENE IN ACID MEDIUM. THE REACTION IS CARRIED OUT IN THE PRESENCE OF WATER OR AN INERT ORGANIC SOLVENT SUCH AS CHLOROFORM OR DICHLOROMETHANE; AN ORGANIC BASE SUCH AS SODIC OR POTASSIC HYDROXIDE; A PHASE TRANSFER CATALYST SUCH AS TETRA-N.BUTYLAMMONIUM HYDROXIDE. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LU83039A LU83039A1 (en) | 1980-12-24 | 1980-12-24 | METHODS OF SYNTHESIS OF 1- (4 ISOPROPYLTHIOPHENYL) -2-N OCTYLAMINOPROPANOL |
Publications (2)
Publication Number | Publication Date |
---|---|
ES522440A0 ES522440A0 (en) | 1984-08-16 |
ES8407018A1 true ES8407018A1 (en) | 1984-08-16 |
Family
ID=19729552
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES508313A Expired ES8308844A1 (en) | 1980-12-24 | 1981-12-23 | Synthesis of 1-(4-isopropylthiophenyl)-2-n- octylaminopropanol, ester and salt of same |
ES522442A Expired ES8407020A1 (en) | 1980-12-24 | 1983-05-16 | Synthesis of 1-(4-isopropylthiophenyl)-2-n- octylaminopropanol, ester and salt of same |
ES522440A Expired ES8407018A1 (en) | 1980-12-24 | 1983-05-16 | Synthesis of 1-(4-isopropylthiophenyl)-2-n- octylaminopropanol, ester and salt of same |
ES522441A Expired ES8407019A1 (en) | 1980-12-24 | 1983-05-16 | Synthesis of 1-(4-isopropylthiophenyl)-2-n- octylaminopropanol, ester and salt of same |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES508313A Expired ES8308844A1 (en) | 1980-12-24 | 1981-12-23 | Synthesis of 1-(4-isopropylthiophenyl)-2-n- octylaminopropanol, ester and salt of same |
ES522442A Expired ES8407020A1 (en) | 1980-12-24 | 1983-05-16 | Synthesis of 1-(4-isopropylthiophenyl)-2-n- octylaminopropanol, ester and salt of same |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522441A Expired ES8407019A1 (en) | 1980-12-24 | 1983-05-16 | Synthesis of 1-(4-isopropylthiophenyl)-2-n- octylaminopropanol, ester and salt of same |
Country Status (11)
Country | Link |
---|---|
JP (4) | JPS5912665B2 (en) |
KR (1) | KR860000340B1 (en) |
AR (1) | AR229799A1 (en) |
AT (1) | AT380872B (en) |
AU (1) | AU548084B2 (en) |
CH (2) | CH654296A5 (en) |
ES (4) | ES8308844A1 (en) |
IL (1) | IL64631A0 (en) |
IT (1) | IT1140399B (en) |
LU (1) | LU83039A1 (en) |
PT (1) | PT74203B (en) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1321701A (en) * | 1969-10-01 | 1973-06-27 | Continental Pharma | Amino-alcohols their salts and process for prepairing the same |
GB1390748A (en) * | 1973-04-09 | 1975-04-16 | Continental Pharma | Alkyl and cycloalkylthiophenylalkylaminoalkanols their salts and the preparation thereof |
LU77237A1 (en) * | 1977-05-03 | 1979-01-18 | ||
IT1082122B (en) * | 1977-07-11 | 1985-05-21 | Medea Res Srl | PROCESS FOR THE PREPARATION OF 1- (4-ISOPROPILMERCAPTO-FENYL) -2-N.OCTYLAMINE-PROPANOL |
LU79970A1 (en) * | 1978-07-13 | 1980-02-14 | Continental Pharma | PROCESS FOR THE PREPARATION OF 1-PHENYL-1-PROPANOL DERIVATIVES |
-
1980
- 1980-12-24 LU LU83039A patent/LU83039A1/en unknown
-
1981
- 1981-12-21 AT AT0549881A patent/AT380872B/en not_active IP Right Cessation
- 1981-12-23 AR AR287941A patent/AR229799A1/en active
- 1981-12-23 ES ES508313A patent/ES8308844A1/en not_active Expired
- 1981-12-23 CH CH443/85A patent/CH654296A5/en not_active IP Right Cessation
- 1981-12-23 CH CH8259/81A patent/CH653325A5/en not_active IP Right Cessation
- 1981-12-23 IL IL64631A patent/IL64631A0/en unknown
- 1981-12-23 PT PT74203A patent/PT74203B/en unknown
- 1981-12-24 KR KR1019810005129A patent/KR860000340B1/en active
- 1981-12-24 IT IT25853/81A patent/IT1140399B/en active
- 1981-12-24 AU AU79025/81A patent/AU548084B2/en not_active Ceased
- 1981-12-24 JP JP56208270A patent/JPS5912665B2/en not_active Expired
-
1982
- 1982-12-06 JP JP57212826A patent/JPS5915905B2/en not_active Expired
- 1982-12-06 JP JP57212825A patent/JPS5938224B2/en not_active Expired
- 1982-12-06 JP JP57212827A patent/JPS5915906B2/en not_active Expired
-
1983
- 1983-05-16 ES ES522442A patent/ES8407020A1/en not_active Expired
- 1983-05-16 ES ES522440A patent/ES8407018A1/en not_active Expired
- 1983-05-16 ES ES522441A patent/ES8407019A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CH653325A5 (en) | 1985-12-31 |
AU7902581A (en) | 1982-07-01 |
JPS5938224B2 (en) | 1984-09-14 |
ES522441A0 (en) | 1984-08-16 |
ES522442A0 (en) | 1984-08-16 |
JPS57134459A (en) | 1982-08-19 |
ES8407020A1 (en) | 1984-08-16 |
IT8125853A0 (en) | 1981-12-24 |
PT74203A (en) | 1982-01-01 |
JPS5915906B2 (en) | 1984-04-12 |
JPS5915905B2 (en) | 1984-04-12 |
CH654296A5 (en) | 1986-02-14 |
KR830007541A (en) | 1983-10-21 |
ES508313A0 (en) | 1983-10-01 |
AR229799A1 (en) | 1983-11-30 |
ES522440A0 (en) | 1984-08-16 |
ATA549881A (en) | 1985-12-15 |
LU83039A1 (en) | 1982-07-07 |
AT380872B (en) | 1986-07-25 |
JPS58113169A (en) | 1983-07-05 |
ES8407019A1 (en) | 1984-08-16 |
PT74203B (en) | 1983-05-20 |
KR860000340B1 (en) | 1986-04-12 |
AU548084B2 (en) | 1985-11-21 |
ES8308844A1 (en) | 1983-10-01 |
JPS58113171A (en) | 1983-07-05 |
IT1140399B (en) | 1986-09-24 |
JPS5912665B2 (en) | 1984-03-24 |
IL64631A0 (en) | 1982-03-31 |
JPS58113170A (en) | 1983-07-05 |
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