ES8405841A1 - Un metodo de producir una composicion pulverulenta, que contiene una serrapeptasa estabilizada. - Google Patents

Un metodo de producir una composicion pulverulenta, que contiene una serrapeptasa estabilizada.

Info

Publication number
ES8405841A1
ES8405841A1 ES518579A ES518579A ES8405841A1 ES 8405841 A1 ES8405841 A1 ES 8405841A1 ES 518579 A ES518579 A ES 518579A ES 518579 A ES518579 A ES 518579A ES 8405841 A1 ES8405841 A1 ES 8405841A1
Authority
ES
Spain
Prior art keywords
serratiopeptidase
solution
freeze
dissolved
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518579A
Other languages
English (en)
Other versions
ES518579A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES518579A0 publication Critical patent/ES518579A0/es
Publication of ES8405841A1 publication Critical patent/ES8405841A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/98—Preparation of granular or free-flowing enzyme compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

METODO PARA ESTABILIZAR UNA SERRAPEPTASA ADECUADA PARA PRODUCIR UNA COMPOSICION EN POLVO.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE PREPARA UNA SOLUCION O UNA SUSPENSION QUE CONTIENE SERRAPEPTASA; SEGUNDA, SE LE AÑADE A DICHA SOLUCION O SUSPENSION QUE CONTIENE SERRAPEPTASA, UNA CANTIDAD COMPRENDIDA ENTRE 0,5 Y 1,5 VECES EL PESO DE SERRAPEPTASA, DE UNA MEZCLA FORMADA POR LACTOSA, SACAROSA, GELATINA, ACIDO ASPARTICO Y ACIDO GLUTAMICO; Y POR ULTIMO, SE LIOFILIZA LA SOLUCION O SUSPENSION RESULTANTE, A UN PH COMPRENDIDO ENTRE 6,5 Y 7,5, A UNA TEMPERATURA COMPRENDIDAENTRE -60 Y 60 GRADOS Y A UNA PRESION COMPRENDIDA ENTRE 10-3 Y 10-1 MM DE HG.DE APLICACION EN MEDICINA POR ACTIVIDAD ANTIINFLAMATORIA.
ES518579A 1981-12-28 1982-12-27 Un metodo de producir una composicion pulverulenta, que contiene una serrapeptasa estabilizada. Expired ES8405841A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56215724A JPS58134991A (ja) 1981-12-28 1981-12-28 セラチオペプチタ−ゼの安定化法

Publications (2)

Publication Number Publication Date
ES518579A0 ES518579A0 (es) 1984-06-16
ES8405841A1 true ES8405841A1 (es) 1984-06-16

Family

ID=16677126

Family Applications (1)

Application Number Title Priority Date Filing Date
ES518579A Expired ES8405841A1 (es) 1981-12-28 1982-12-27 Un metodo de producir una composicion pulverulenta, que contiene una serrapeptasa estabilizada.

Country Status (7)

Country Link
JP (1) JPS58134991A (es)
KR (1) KR870000237B1 (es)
ES (1) ES8405841A1 (es)
FR (1) FR2519021B1 (es)
GR (1) GR78417B (es)
IT (1) IT1157994B (es)
PT (1) PT76042B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017111569A1 (es) * 2015-12-21 2017-06-29 Clinica De Avances Oculares, S.A.P.I. De C.V. Combinación y formulación farmacéutica, para el tratamiento de enfermedades oculares

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1230300A (en) * 1983-06-06 1987-12-15 Michael K. Hoskins Stabilized isoenzyme control product
US5405767A (en) * 1992-04-08 1995-04-11 Solvay Enzymes, Inc. Purified enzyme concentrate and method of preparation
US6288030B1 (en) * 1993-12-22 2001-09-11 Amgen Inc. Stem cell factor formulations and methods
DE69523163T2 (de) * 1994-07-20 2002-03-07 Kyowa Hakko Kogyo Kk Verfahren zur herstellung von stabilisierter getrockeneter carboxyesterase
CU23475A1 (es) 2004-07-08 2009-12-17 Ct Ingenieria Genetica Biotech Composición farmacéutica conteniendo fragmentos polipeptídicos de serralisinas
KR100667852B1 (ko) 2006-01-13 2007-01-11 삼성전자주식회사 휴대용 레코더 기기의 잡음 제거 장치 및 그 방법
CN108309941B (zh) * 2018-03-20 2023-08-11 南京工业大学 一种舍雷肽酶外用粉剂及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1352103A (fr) * 1960-02-26 1964-02-14 Procédé de stabilisation d'enzymes sensibles ou instables spécialement de la catalase
FR1533993A (fr) * 1967-06-13 1968-07-26 Takeda Chemical Industries Ltd Procédé de préparation d'une protéase
JPS5534001A (en) * 1978-08-28 1980-03-10 Noda Sangyo Kagaku Kenkyusho Stabilization of sarcosine oxidase
FR2444465A1 (fr) * 1978-12-22 1980-07-18 Green Cross Corp Procede de production d'une preparation thrombolytique

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017111569A1 (es) * 2015-12-21 2017-06-29 Clinica De Avances Oculares, S.A.P.I. De C.V. Combinación y formulación farmacéutica, para el tratamiento de enfermedades oculares

Also Published As

Publication number Publication date
PT76042B (en) 1986-01-27
FR2519021B1 (fr) 1985-07-26
IT1157994B (it) 1987-02-18
FR2519021A1 (fr) 1983-07-01
IT8268523A0 (it) 1982-12-27
ES518579A0 (es) 1984-06-16
PT76042A (en) 1983-01-01
KR870000237B1 (ko) 1987-02-18
JPS58134991A (ja) 1983-08-11
GR78417B (es) 1984-09-27
JPH0218069B2 (es) 1990-04-24
KR840002901A (ko) 1984-07-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102