FR2444465A1 - Procede de production d'une preparation thrombolytique - Google Patents
Procede de production d'une preparation thrombolytiqueInfo
- Publication number
- FR2444465A1 FR2444465A1 FR7836125A FR7836125A FR2444465A1 FR 2444465 A1 FR2444465 A1 FR 2444465A1 FR 7836125 A FR7836125 A FR 7836125A FR 7836125 A FR7836125 A FR 7836125A FR 2444465 A1 FR2444465 A1 FR 2444465A1
- Authority
- FR
- France
- Prior art keywords
- urokinase
- prodn
- maintaining
- produced
- processing step
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Procédé de production d'une préparation thrombolytique contenant comme constituant principal une urokinase ayant une masse moléculaire de 54 000 +- 10 000. Parmi les conditions de traitement de la production de l'urokinase, le pH est maintenu dans le domaine neutre ou faiblement alcalin sur toute la durée de chaque stade du traitement pour produire une préparation thrombolytique contenant de l'urokinase ayant une masse moléculaire de 54 000 + 10 000 comme ingrédient principal. Application en médecine.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7836125A FR2444465A1 (fr) | 1978-12-22 | 1978-12-22 | Procede de production d'une preparation thrombolytique |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7836125A FR2444465A1 (fr) | 1978-12-22 | 1978-12-22 | Procede de production d'une preparation thrombolytique |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2444465A1 true FR2444465A1 (fr) | 1980-07-18 |
FR2444465B1 FR2444465B1 (fr) | 1984-11-16 |
Family
ID=9216456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7836125A Granted FR2444465A1 (fr) | 1978-12-22 | 1978-12-22 | Procede de production d'une preparation thrombolytique |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2444465A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2519021A1 (fr) * | 1981-12-28 | 1983-07-01 | Takeda Chemical Industries Ltd | Procede de stabilisation de la serrapeptase, composition contenant cette serrapeptase stabilisee et preparation de cette composition |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49125584A (fr) * | 1973-04-11 | 1974-12-02 | ||
FR2258396A1 (fr) * | 1974-01-22 | 1975-08-18 | Green Cross Corp | |
JPS5120596A (fr) * | 1974-08-11 | 1976-02-18 | Hitachi Maxell | |
JPS5135481A (ja) * | 1974-09-18 | 1976-03-25 | Fujiwa Kako Kk | Kojundohitorokinaaze no seiho |
FR2291983A1 (fr) * | 1974-11-20 | 1976-06-18 | Abbott Lab | Purification de l'urokinase |
JPS52105279A (en) * | 1976-03-01 | 1977-09-03 | Wakamoto Pharma Co Ltd | Collfcting method of urokinase and novel absorbing agent used in said method |
US4066506A (en) * | 1976-10-08 | 1978-01-03 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Method of separating and purifying two active forms of urokinase using affinity chromatography |
JPS53142593A (en) * | 1977-12-12 | 1978-12-12 | Green Cross Corp:The | Stabilization of urokinase by heating |
-
1978
- 1978-12-22 FR FR7836125A patent/FR2444465A1/fr active Granted
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49125584A (fr) * | 1973-04-11 | 1974-12-02 | ||
FR2258396A1 (fr) * | 1974-01-22 | 1975-08-18 | Green Cross Corp | |
JPS5120596A (fr) * | 1974-08-11 | 1976-02-18 | Hitachi Maxell | |
JPS5135481A (ja) * | 1974-09-18 | 1976-03-25 | Fujiwa Kako Kk | Kojundohitorokinaaze no seiho |
FR2291983A1 (fr) * | 1974-11-20 | 1976-06-18 | Abbott Lab | Purification de l'urokinase |
JPS52105279A (en) * | 1976-03-01 | 1977-09-03 | Wakamoto Pharma Co Ltd | Collfcting method of urokinase and novel absorbing agent used in said method |
US4066506A (en) * | 1976-10-08 | 1978-01-03 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Method of separating and purifying two active forms of urokinase using affinity chromatography |
JPS53142593A (en) * | 1977-12-12 | 1978-12-12 | Green Cross Corp:The | Stabilization of urokinase by heating |
Non-Patent Citations (4)
Title |
---|
ABJP/79 * |
CA1975 * |
CA1976 * |
CA1977 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2519021A1 (fr) * | 1981-12-28 | 1983-07-01 | Takeda Chemical Industries Ltd | Procede de stabilisation de la serrapeptase, composition contenant cette serrapeptase stabilisee et preparation de cette composition |
Also Published As
Publication number | Publication date |
---|---|
FR2444465B1 (fr) | 1984-11-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |