ES8405771A1 - Un procedimiento para la preparacion de pirimidin-2-onas-sustituidas. - Google Patents

Un procedimiento para la preparacion de pirimidin-2-onas-sustituidas.

Info

Publication number
ES8405771A1
ES8405771A1 ES517865A ES517865A ES8405771A1 ES 8405771 A1 ES8405771 A1 ES 8405771A1 ES 517865 A ES517865 A ES 517865A ES 517865 A ES517865 A ES 517865A ES 8405771 A1 ES8405771 A1 ES 8405771A1
Authority
ES
Spain
Prior art keywords
group
ring
heterocyclic
hydrogen atom
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517865A
Other languages
English (en)
Other versions
ES517865A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nyegaard and Co AS
Original Assignee
Nyegaard and Co AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard and Co AS filed Critical Nyegaard and Co AS
Publication of ES517865A0 publication Critical patent/ES517865A0/es
Publication of ES8405771A1 publication Critical patent/ES8405771A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE PIRIMIDIN-2-ONAS-SUSTITUIDAS, DE FORMULA GENERAL (I), EN LA QUE X REPRESENTA UN ATOMO DE HALOGENO O UN GRUPO TRIFLUOROMETILO; R Y R REPRESENTAN, INDEPENDIENTEMENTE, UN ATOMO DE HIDROGENO O UN GRUPO ALCOHILO INFERIOR; Z REPRESENTA UN ATOMO DE OXIGENO O UN ATOMO DE AZUFRE; R REPRESENTA UN GRUPO AROMATICO CARBOCICLICO O UN GRUPO HETEROCICLICO; Y R REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALCOHILO INFERIOR, ALQUENILO INFERIOR O ALCANOILO INFERIOR, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA(II) CON UN COMPUESTO DE FORMULA: R-ZH, EN LAS QUE R, R, R Y X TIENEN LOS SIGNIFICADOS YA INDICADOS; E Y REPRESENTA UN ATOMO DE HALOGENO, UN GRUPO HIDROXILO O UN GRUPO MERCAPTO.DE APLICACION EN FARMACIA PARA COMBATIR LA PROLIFERACION ANORMAL DE CELULAS.
ES517865A 1981-01-09 1982-12-01 Un procedimiento para la preparacion de pirimidin-2-onas-sustituidas. Expired ES8405771A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8100613 1981-01-09

Publications (2)

Publication Number Publication Date
ES517865A0 ES517865A0 (es) 1984-06-16
ES8405771A1 true ES8405771A1 (es) 1984-06-16

Family

ID=10518891

Family Applications (2)

Application Number Title Priority Date Filing Date
ES508593A Expired ES8304945A1 (es) 1981-01-09 1982-01-08 "un procedimiento para la preparacion de pirimidin-2-onas sustituidas".
ES517865A Expired ES8405771A1 (es) 1981-01-09 1982-12-01 Un procedimiento para la preparacion de pirimidin-2-onas-sustituidas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES508593A Expired ES8304945A1 (es) 1981-01-09 1982-01-08 "un procedimiento para la preparacion de pirimidin-2-onas sustituidas".

Country Status (12)

Country Link
US (2) US4596870A (es)
EP (1) EP0056319B1 (es)
JP (1) JPS57136575A (es)
AT (1) ATE19242T1 (es)
AU (1) AU7929482A (es)
CA (1) CA1180710A (es)
DE (1) DE3270525D1 (es)
DK (1) DK5382A (es)
ES (2) ES8304945A1 (es)
NO (1) NO160514C (es)
NZ (1) NZ199447A (es)
ZA (1) ZA82125B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58159479A (ja) * 1982-02-24 1983-09-21 ニユエガ−ド・アンド・コンパニ−・アクシエ／セルカペト 置換されたピリミジン−２−オン化合物
GB2135992B (en) * 1983-01-11 1986-09-24 Nyegaard & Co As Substituted pyrimidines and processes for their preparation
DE3461796D1 (en) * 1983-02-23 1987-02-05 Bayer Ag Agent for regulating the growth of plants
GB8411291D0 (en) * 1984-05-02 1984-06-06 Nyegaard & Co As Chemical compounds
US4864021A (en) * 1984-10-30 1989-09-05 Otsuka Pharmaceutical Co., Ltd. 5-fluorouracil derivatives
US4675321A (en) * 1986-02-07 1987-06-23 Merck & Co., Inc. Substituted pyrimidines useful as calcium channel blockers
US4849426A (en) * 1987-05-15 1989-07-18 Pearlman Dale L Method for treating actinic keratosis with cytotoxic agents
US4853388A (en) * 1987-05-15 1989-08-01 Pearlman Dale L Method for treating psoriasis with cytotoxic agents
US4820711A (en) * 1987-05-15 1989-04-11 Pearlman Dale L Method for treating actinic keratosis with cytotoxic agents
US8933239B1 (en) * 2013-07-16 2015-01-13 Dow Global Technologies Llc Bis(aryl)acetal compounds
GB201321734D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1561290A (en) * 1975-10-16 1980-02-20 Nyegaard & Co As Pyrimid - 2 - ones
US4044008A (en) * 1976-10-06 1977-08-23 Morton-Norwich Products, Inc. 1-[2-Hydroxy-3-(2-naphthoxy)propyl]-2(1H)pyrimidone hydrochloride
ES498337A0 (es) * 1980-01-07 1982-06-01 Nyegaard & Co As Un procedimiento para la preparacion de 5-halo-pirimidin-2- onas
AU549117B2 (en) * 1980-01-10 1986-01-16 Nyegaard & Co. A/S Pyrimidine-2-sulphides and their 5-oxides
JPS58159479A (ja) * 1982-02-24 1983-09-21 ニユエガ−ド・アンド・コンパニ−・アクシエ／セルカペト 置換されたピリミジン−２−オン化合物

Also Published As

Publication number Publication date
ATE19242T1 (de) 1986-05-15
EP0056319A3 (en) 1982-10-27
CA1180710A (en) 1985-01-08
ES508593A0 (es) 1983-03-16
US4596870A (en) 1986-06-24
NO820049L (no) 1982-07-12
DE3270525D1 (en) 1986-05-22
NO160514B (no) 1989-01-16
EP0056319B1 (en) 1986-04-16
EP0056319A2 (en) 1982-07-21
NO160514C (no) 1989-04-26
AU7929482A (en) 1982-07-15
ES517865A0 (es) 1984-06-16
US4705791A (en) 1987-11-10
NZ199447A (en) 1985-08-16
ZA82125B (en) 1982-12-29
DK5382A (da) 1982-07-10
ES8304945A1 (es) 1983-03-16
JPS57136575A (en) 1982-08-23

Similar Documents

Publication Publication Date Title
DK159148C (da) Analogifremgangsmaade til fremstilling af tranexamsyrederivater
ES8405771A1 (es) Un procedimiento para la preparacion de pirimidin-2-onas-sustituidas.
ES8304538A1 (es) "procedimiento para la preparacion de nuevas fenilalcohilaminas".
ES466366A1 (es) Un procedimiento para preparar derivados de metasulfonamido-benzamida.
DE3371512D1 (en) Substituted pyrimidin-2-ones and the salts thereof
DE3174132D1 (en) New ethenylimidazole derivatives, processes for their preparation and pharmaceutical compositions containing them; intermediates, useful in their preparation and a process for the preparation thereof
SE8302481L (sv) Karbazinderivat, forfarande for framstellning derav samt kompositioner innehallande desamma
ES483279A1 (es) Procedimiento para la obtencion de n-pirazolilmetil-haloge- noacetanilidas sustituidas
JPS57128674A (en) Growth regulant alpha-azolylglycol, manufacture and plant growth regulant containing same
HUT39445A (en) Herbicides containing as reagent derivatives of benzodisultam and process for production of the reagents
ES8502699A1 (es) Procedimiento para la obtencion de tetrahidrotiopiran-3, 5-dion-4-carboxamidas
DE69006607D1 (de) Verfahren zur Herstellung von Carbamaten und dabei auftretende Zwischenprodukte.
ES490675A0 (es) Un procedimiento para la preparacion de nuevos derivados de oxazolina y tiazolina
ES8600204A1 (es) Procedimiento de preparacion de nuevos deridados de alfa-etibenzol con un grupo amino propanolico sustituido y sus sales de adicion acidas y amonicas cuaternarias.
ES476889A1 (es) Procedimiento para la obtencion de derivados de la isoquino-leina.