ES8404787A1 - Procedimiento para la preparacion de 7 -alcohil-17 -pregn4-en-21,17-carbolactonas y -21-sales de acidos carboxilicos - Google Patents

Procedimiento para la preparacion de 7 -alcohil-17 -pregn4-en-21,17-carbolactonas y -21-sales de acidos carboxilicos

Info

Publication number
ES8404787A1
ES8404787A1 ES525672A ES525672A ES8404787A1 ES 8404787 A1 ES8404787 A1 ES 8404787A1 ES 525672 A ES525672 A ES 525672A ES 525672 A ES525672 A ES 525672A ES 8404787 A1 ES8404787 A1 ES 8404787A1
Authority
ES
Spain
Prior art keywords
alpha
carbolactones
pregn
ene
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525672A
Other languages
English (en)
Other versions
ES525672A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES525672A0 publication Critical patent/ES525672A0/es
Publication of ES8404787A1 publication Critical patent/ES8404787A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 7A-ALCOHIL-17-A-PREGN-4- EN-21,17-CARBOLACTONAS Y -21-SALES DE ACIDOS CARBOXILICOS.CONSISTE EN HACER REACCIONAR COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE GRINARD DE FORMULA (III), EN PRESENCIA DE UNA SAL DE COBRE O DE UN COMPUESTO DE FORMULA (R)2 CU LI, INTRODUCIR UN DOBLE ENLACE A1 Y DESDOBLAR EL ANILLO LACTONICO POR ACCION DE UN HIDROXIDO DE METAL ALCALINO, PARA FORMAR COMPUESTOS DE FORMULA (I), DONDE C1---C2 SIGNIFICA UN ENLACE SIMPLE O DOBLE; R SIGNIFICA RADICAL ALCOHILO CON C 1 A 6 SATURADO O INSATURADO, DE CADENA RECTAO RAMIFICADA, SUSTITUIDO O NO POR CLORO O GRUPO HIDROXI; E REPRESENTA LAS AGRUPACIONES DE FORMULA (IV); M ES UN METAL ALCALINO TAL COMO POTASIO; Y HAL ES UN ATOMO DE CLORO, BROMO O YODO. SE LLEVA A CABO A TEMPERATURAS ENTRE C30 HASTA B20JC Y LOS ACIDOS EMPLEADOS SON DEL TIPO CLORHIDRICO O SULFURICO.TIENE APLICACION PARA EL TRATAMIENTO DE LA HIPERTONIA.
ES525672A 1982-09-17 1983-09-16 Procedimiento para la preparacion de 7 -alcohil-17 -pregn4-en-21,17-carbolactonas y -21-sales de acidos carboxilicos Expired ES8404787A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823234972 DE3234972A1 (de) 1982-09-17 1982-09-17 7(alpha)-alkyl-17(alpha)-pregn-4-en-21.17-carbolactone und -21-carbonsaeuresalze sowie verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

Publications (2)

Publication Number Publication Date
ES525672A0 ES525672A0 (es) 1984-06-01
ES8404787A1 true ES8404787A1 (es) 1984-06-01

Family

ID=6173787

Family Applications (1)

Application Number Title Priority Date Filing Date
ES525672A Expired ES8404787A1 (es) 1982-09-17 1983-09-16 Procedimiento para la preparacion de 7 -alcohil-17 -pregn4-en-21,17-carbolactonas y -21-sales de acidos carboxilicos

Country Status (6)

Country Link
EP (1) EP0106793A1 (es)
JP (1) JPS5970700A (es)
AU (1) AU1861183A (es)
DE (1) DE3234972A1 (es)
DK (1) DK412783A (es)
ES (1) ES8404787A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3402329A1 (de) * 1984-01-20 1985-08-01 Schering AG, 1000 Berlin und 4709 Bergkamen 6,6-ethylen-15,16-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE3612632A1 (de) * 1986-04-11 1987-10-22 Schering Ag Verfahren zur herstellung von 7(alpha)-propylsteroiden

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845041A (en) * 1973-12-26 1974-10-29 Searle & Co 7-halomethyl-17-hydroxy-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid gamma-lactones
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
FR2451923A1 (fr) * 1979-03-22 1980-10-17 Roussel Uclaf Nouveaux derives steroides 7-alkyles, leur procede de preparation et leur application comme medicament

Also Published As

Publication number Publication date
EP0106793A1 (en) 1984-04-25
DK412783A (da) 1984-03-18
JPS5970700A (ja) 1984-04-21
ES525672A0 (es) 1984-06-01
DE3234972A1 (de) 1984-03-22
DK412783D0 (da) 1983-09-12
AU1861183A (en) 1984-03-22

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