ES8402319A1 - Procedimiento para la fabricacion de heparinas de bajo peso molecular, por despolimerizacion de la heparina normal. - Google Patents
Procedimiento para la fabricacion de heparinas de bajo peso molecular, por despolimerizacion de la heparina normal.Info
- Publication number
- ES8402319A1 ES8402319A1 ES519015A ES519015A ES8402319A1 ES 8402319 A1 ES8402319 A1 ES 8402319A1 ES 519015 A ES519015 A ES 519015A ES 519015 A ES519015 A ES 519015A ES 8402319 A1 ES8402319 A1 ES 8402319A1
- Authority
- ES
- Spain
- Prior art keywords
- molecular weight
- low molecular
- heparin
- depolymerization
- normal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 6
- 229920000669 heparin Polymers 0.000 title abstract 6
- 229960002897 heparin Drugs 0.000 title abstract 4
- 229940127215 low-molecular weight heparin Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000003055 low molecular weight heparin Substances 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39921782A | 1982-07-19 | 1982-07-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES519015A0 ES519015A0 (es) | 1984-02-01 |
| ES8402319A1 true ES8402319A1 (es) | 1984-02-01 |
Family
ID=23578637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519015A Expired ES8402319A1 (es) | 1982-07-19 | 1983-01-14 | Procedimiento para la fabricacion de heparinas de bajo peso molecular, por despolimerizacion de la heparina normal. |
Country Status (10)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1214609B (it) * | 1985-05-17 | 1990-01-18 | Opocrin Spa | Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono. |
| US4745106A (en) * | 1986-08-20 | 1988-05-17 | Griffin Charles C | Heparin derivatives having improved anti-Xa specificity |
| US4942156A (en) * | 1986-08-20 | 1990-07-17 | Hepar Industries, Inc. | Low molecular weight heparin derivatives having improved anti-Xa specificity |
| ES2071608T3 (es) * | 1986-08-20 | 1995-07-01 | Univ Miami | Esteres de alcanoilo de heparina de bajo peso molecular. |
| US6001820A (en) * | 1995-03-31 | 1999-12-14 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US5763427A (en) * | 1995-03-31 | 1998-06-09 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US5744457A (en) * | 1995-03-31 | 1998-04-28 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US5767269A (en) * | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
| FR2763848B1 (fr) * | 1997-05-28 | 2000-01-28 | Rhone Poulenc Rorer Sa | Utilisation des heparines de bas poids moleculaire pour la prevention et le traitement du trauma du systeme nerveux central |
| EP1192187A1 (en) * | 1999-06-30 | 2002-04-03 | Hamilton Civic Hospitals Research Development, Inc. | Heparin compositions that inhibit clot associated coagulation factors |
| JP2002293804A (ja) * | 2001-03-28 | 2002-10-09 | Itoham Foods Inc | 低分子量ヘパリンの製造法 |
| AU2020310172A1 (en) | 2019-07-09 | 2022-03-03 | Optimvia Llc | Methods for synthesizing anticoagulant polysaccharides |
| EP4182452A4 (en) | 2020-07-14 | 2024-07-31 | Optimvia, LLC | METHOD FOR THE SYNTHESIS OF NON-ANTICOAGULATING HEPARAN SULFATE |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3179566A (en) * | 1963-05-16 | 1965-04-20 | Canada Packers Ltd | Purification of heparin |
| US3482014A (en) * | 1966-06-29 | 1969-12-02 | Canada Packers Ltd | Orally active heparin and method for making and using same |
| CA1136620A (en) * | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Heparin fragments having selective anticoagulation activity |
| JPS56120704A (en) * | 1980-01-28 | 1981-09-22 | Hepar Ind Inc | Method of obtaining low molecular weight heparin having heightened pharmacologic property* product manufactured thereby and its use |
| US4281108A (en) * | 1980-01-28 | 1981-07-28 | Hepar Industries, Inc. | Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained |
-
1982
- 1982-12-23 ZA ZA829463A patent/ZA829463B/xx unknown
- 1982-12-23 CA CA000418428A patent/CA1195322A/en not_active Expired
-
1983
- 1983-01-12 AU AU10331/83A patent/AU1033183A/en not_active Abandoned
- 1983-01-12 NZ NZ202996A patent/NZ202996A/en unknown
- 1983-01-12 JP JP58003271A patent/JPS5920302A/ja active Granted
- 1983-01-12 EP EP83300155A patent/EP0101141A3/en not_active Withdrawn
- 1983-01-14 ES ES519015A patent/ES8402319A1/es not_active Expired
- 1983-01-19 PT PT76111A patent/PT76111A/pt unknown
- 1983-01-21 AR AR291924A patent/AR231644A1/es active
- 1983-07-14 DK DK198303255A patent/DK172798B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1195322A (en) | 1985-10-15 |
| DK172798B1 (da) | 1999-07-19 |
| EP0101141A2 (en) | 1984-02-22 |
| DK325583A (da) | 1984-01-20 |
| AR231644A1 (es) | 1985-01-31 |
| AU1033183A (en) | 1984-01-26 |
| NZ202996A (en) | 1985-10-11 |
| JPS5920302A (ja) | 1984-02-02 |
| DK325583D0 (da) | 1983-07-14 |
| ES519015A0 (es) | 1984-02-01 |
| EP0101141A3 (en) | 1985-05-22 |
| JPH0442401B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-07-13 |
| PT76111A (en) | 1983-02-01 |
| ZA829463B (en) | 1983-10-26 |
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