ES8401076A1 - Mejoras introducidas en un procedimiento de preparacion de acido 6,6-diyodopenicilanico. - Google Patents
Mejoras introducidas en un procedimiento de preparacion de acido 6,6-diyodopenicilanico.Info
- Publication number
- ES8401076A1 ES8401076A1 ES515434A ES515434A ES8401076A1 ES 8401076 A1 ES8401076 A1 ES 8401076A1 ES 515434 A ES515434 A ES 515434A ES 515434 A ES515434 A ES 515434A ES 8401076 A1 ES8401076 A1 ES 8401076A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- acid
- pure
- beta
- diiodopenicillanic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO MEJORADO PARA LA PREPARACION DE ACIDO 6,6-DIYODOPENICILANICO.CONSISTE EN LAS SIGUIENTES FASES: REACCION DE DIAZOTACION DEL ACIDO 6-B-AMINOPENICILANICO, 6-APA, EN UN DISOLVENTE INERTE A LA REACCION, TAL COMO ACETATO DE ETILO, CLORURO DE METILENO, TOLUENO, ETER DIETILICO Y ETER DIISOPROPILICO, A UNA TEMPERATURA COMPRENDIDA ENTRE LOS 0º C Y LOS 10º C, CON ACIDO SULFURICO Y NITRITO SODICO, EN PRESENCIA DE YODO, QUE SE AGREGA EN FORMA SOLIDA O EN SOLUCION CON UN DISOLVENTE INERTE A LA REACCION, COMO ACETATO DE ETILO, ETER DIETILICO Y OTROS, EN UNAS RELACIONES MOLARES DE 6-APA: NANO 2:2 DE 1:2:1 A 1:2:3 APROXIMADAMENTE; RECUPERACION DEL PRODUCTO DE REACCION POR SEPARACION DE LA FASE ORGANICA SEGUIDA DE EVAPORACION DE LA MISMA; LAVADO DEL RESIDUO SOLIDO ANTERIOR CON UNA SOLUCION ACUOSA DE UN YODURO METALICO ALCALINO, TAL COMO YODURO SODICO O POTASICO, A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 100º C, NORMALMENTE A TEMPERATURA AMBIENTE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/298,678 US4360463A (en) | 1981-09-02 | 1981-09-02 | Pure 6,6-diiodopenicillanic acid and process for its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES515434A0 ES515434A0 (es) | 1983-12-01 |
| ES8401076A1 true ES8401076A1 (es) | 1983-12-01 |
Family
ID=23151550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES515434A Expired ES8401076A1 (es) | 1981-09-02 | 1982-09-01 | Mejoras introducidas en un procedimiento de preparacion de acido 6,6-diyodopenicilanico. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4360463A (es) |
| EP (1) | EP0073674B1 (es) |
| JP (1) | JPS5883695A (es) |
| KR (1) | KR860000854B1 (es) |
| AR (1) | AR229132A1 (es) |
| AT (1) | ATE17487T1 (es) |
| AU (1) | AU533721B2 (es) |
| CA (1) | CA1171406A (es) |
| DE (1) | DE3268558D1 (es) |
| DK (1) | DK154143C (es) |
| ES (1) | ES8401076A1 (es) |
| FI (1) | FI75164C (es) |
| GR (1) | GR77270B (es) |
| HU (1) | HU187787B (es) |
| IE (1) | IE53648B1 (es) |
| IL (1) | IL66691A (es) |
| PH (1) | PH17619A (es) |
| PL (1) | PL130873B1 (es) |
| PT (1) | PT75490B (es) |
| YU (1) | YU42796B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT76526B (en) * | 1982-04-19 | 1986-01-21 | Gist Brocades Nv | Preparation of 6-alpha-bromo- and/or 6,6-dibromopenicillanic acid 1,1-dioxides |
| EP0139047A1 (en) * | 1983-10-18 | 1985-05-02 | Gist-Brocades N.V. | Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2051046B (en) * | 1979-05-21 | 1984-03-28 | Leo Pharm Prod Ltd | Penicillanic acid derivatives |
-
1981
- 1981-09-02 US US06/298,678 patent/US4360463A/en not_active Expired - Fee Related
-
1982
- 1982-08-31 DE DE8282304562T patent/DE3268558D1/de not_active Expired
- 1982-08-31 EP EP82304562A patent/EP0073674B1/en not_active Expired
- 1982-08-31 KR KR8203927A patent/KR860000854B1/ko active
- 1982-08-31 AT AT82304562T patent/ATE17487T1/de not_active IP Right Cessation
- 1982-08-31 AR AR290489A patent/AR229132A1/es active
- 1982-08-31 GR GR69172A patent/GR77270B/el unknown
- 1982-09-01 PT PT75490A patent/PT75490B/pt not_active IP Right Cessation
- 1982-09-01 YU YU1969/82A patent/YU42796B/xx unknown
- 1982-09-01 ES ES515434A patent/ES8401076A1/es not_active Expired
- 1982-09-01 HU HU822812A patent/HU187787B/hu not_active IP Right Cessation
- 1982-09-01 FI FI823025A patent/FI75164C/fi not_active IP Right Cessation
- 1982-09-01 IE IE2117/82A patent/IE53648B1/en unknown
- 1982-09-01 AU AU87908/82A patent/AU533721B2/en not_active Ceased
- 1982-09-01 CA CA000410554A patent/CA1171406A/en not_active Expired
- 1982-09-01 PL PL1982238107A patent/PL130873B1/pl unknown
- 1982-09-01 DK DK391482A patent/DK154143C/da not_active IP Right Cessation
- 1982-09-01 IL IL66691A patent/IL66691A/xx unknown
- 1982-09-02 PH PH27813A patent/PH17619A/en unknown
- 1982-09-02 JP JP57153361A patent/JPS5883695A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IE822117L (en) | 1983-03-02 |
| IE53648B1 (en) | 1989-01-04 |
| DE3268558D1 (en) | 1986-02-27 |
| DK391482A (da) | 1983-03-03 |
| PL238107A1 (en) | 1983-05-09 |
| HU187787B (en) | 1986-02-28 |
| AU533721B2 (en) | 1983-12-08 |
| YU42796B (en) | 1988-12-31 |
| US4360463A (en) | 1982-11-23 |
| IL66691A (en) | 1985-03-31 |
| IL66691A0 (en) | 1982-12-31 |
| JPS5883695A (ja) | 1983-05-19 |
| PT75490B (en) | 1985-11-12 |
| GR77270B (es) | 1984-09-11 |
| ATE17487T1 (de) | 1986-02-15 |
| EP0073674B1 (en) | 1986-01-15 |
| PH17619A (en) | 1984-10-05 |
| KR860000854B1 (ko) | 1986-07-09 |
| ES515434A0 (es) | 1983-12-01 |
| DK154143B (da) | 1988-10-17 |
| FI75164B (fi) | 1988-01-29 |
| CA1171406A (en) | 1984-07-24 |
| JPH0310633B2 (es) | 1991-02-14 |
| KR840001179A (ko) | 1984-03-28 |
| FI823025A0 (fi) | 1982-09-01 |
| EP0073674A1 (en) | 1983-03-09 |
| FI75164C (fi) | 1988-05-09 |
| DK154143C (da) | 1989-03-13 |
| PT75490A (en) | 1982-10-01 |
| YU196982A (en) | 1984-12-31 |
| AR229132A1 (es) | 1983-06-15 |
| AU8790882A (en) | 1983-03-31 |
| PL130873B1 (en) | 1984-09-29 |
| FI823025L (fi) | 1983-03-03 |
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