ES8401047A1 - Un procedimiento para la prepracion de nitrilos antiinflamatorios. - Google Patents
Un procedimiento para la prepracion de nitrilos antiinflamatorios.Info
- Publication number
- ES8401047A1 ES8401047A1 ES516508A ES516508A ES8401047A1 ES 8401047 A1 ES8401047 A1 ES 8401047A1 ES 516508 A ES516508 A ES 516508A ES 516508 A ES516508 A ES 516508A ES 8401047 A1 ES8401047 A1 ES 8401047A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrazino
- benzoxazolyl
- alkyl nitrile
- nitrile derivatives
- loweralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 1-(2-benzoxazolyl)hydrazino Chemical group 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE NITRILOS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES HIDROGENO O ALQUILO INFERIOR; X, Y Y Z PUEDEN SER VARIOS TIPOS DE RADICALES Y M Y N VALEN DE 0 A 6; COMPUESTOS QUE TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIINFLAMATORIOS.CONSISTE EN LA REACCION DE UN DERIVADO HIDRAZINO ADECUADO CON ACRILONITRILO EN UN DISOLVENTE INERTE O EN AUSENCIA DEL MISMO, EN PRESENCIA DE UNAS BASES TAL COMO COLINA, HIDROXIDO SODICO O ETOXIDO SODICO, A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y 150JC.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31184381A | 1981-10-16 | 1981-10-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES516508A0 ES516508A0 (es) | 1983-11-16 |
| ES8401047A1 true ES8401047A1 (es) | 1983-11-16 |
Family
ID=23208752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES516508A Expired ES8401047A1 (es) | 1981-10-16 | 1982-10-14 | Un procedimiento para la prepracion de nitrilos antiinflamatorios. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4476137A (es) |
| EP (1) | EP0091468B1 (es) |
| JP (1) | JPS58501722A (es) |
| AU (1) | AU553775B2 (es) |
| CA (1) | CA1183540A (es) |
| CH (1) | CH654573A5 (es) |
| DE (1) | DE3249054T1 (es) |
| ES (1) | ES8401047A1 (es) |
| GB (1) | GB2116964B (es) |
| GR (1) | GR77022B (es) |
| IT (1) | IT1191037B (es) |
| NL (1) | NL8220390A (es) |
| NZ (1) | NZ202071A (es) |
| PH (1) | PH17577A (es) |
| PT (1) | PT75676B (es) |
| SE (1) | SE454175B (es) |
| WO (1) | WO1983001448A1 (es) |
| ZA (1) | ZA827307B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3419994A1 (de) * | 1984-05-29 | 1985-12-05 | Hoechst Ag, 6230 Frankfurt | Benzoxazolyl- und benzthiazolyl-aminosaeuren, ihre herstellung und verwendung im pflanzenschutz |
| DE60229695D1 (de) * | 2001-08-10 | 2008-12-18 | Samsung Electronics Co Ltd | Elektrophotographischer organischer Photorezeptor mit Ladungsübertragungsmitteln |
| EP1293837B1 (en) | 2001-09-14 | 2008-10-08 | Samsung Electronics Co., Ltd. | Electrophotographic organophotoreceptors |
| US7118839B2 (en) * | 2001-09-28 | 2006-10-10 | Samsung Electronics Co., Ltd. | Electrophotographic organophotoreceptors with novel charge transport materials |
| US6905804B2 (en) * | 2002-02-08 | 2005-06-14 | Samsung Electronics Co., Ltd. | Electrophotographic organophotoreceptors with novel charge transport materials |
| US6835514B2 (en) * | 2002-03-28 | 2004-12-28 | Samsung Electronics Co., Ltd. | Hydrazone-based charge transport compounds |
| US6864028B1 (en) | 2002-03-28 | 2005-03-08 | Samsung Electronics Co., Ltd. | Di-hydrazone based charge transport compounds |
| US6864025B2 (en) * | 2002-03-28 | 2005-03-08 | Samsung Electronics Co., Ltd. | Sulfonyldiphenylene-based charge transport compositions |
| US6835513B2 (en) * | 2002-03-28 | 2004-12-28 | Samsung Electronic Co., Ltd. | Carbazole based charge transport compounds |
| US6815133B2 (en) * | 2002-04-12 | 2004-11-09 | Samsung Electronics Co., Ltd. | Sulfonyldiphenylene based charge transport compositions |
| US6964833B2 (en) * | 2002-05-31 | 2005-11-15 | Samsung Electronics Co., Ltd. | Linked dihydrazone-based charge transport compounds |
| US6899984B2 (en) * | 2002-05-31 | 2005-05-31 | Samsung Electronics Co., Ltd. | Linked dihydrazone-based charge transport compounds |
| US7090953B2 (en) * | 2002-10-25 | 2006-08-15 | Samsung Electronics Co., Ltd. | Organophotoreceptor with a charge transport compound having an epoxy group |
| US7029812B2 (en) * | 2002-10-25 | 2006-04-18 | Samsung Electronics Co., Ltd. | Organophotoreceptor with charge transport compound having an epoxy group |
| JP5932830B2 (ja) | 2010-12-15 | 2016-06-08 | オラテック セラピューティクス リミティド ライアビリティ カンパニー | 炎症及び疼痛を処置するための３‐メタンスルホニルプロピオニトリル |
| KR101985943B1 (ko) * | 2011-04-27 | 2019-06-04 | 제온 코포레이션 | 중합성 화합물, 중합성 조성물, 고분자, 및 광학 이방체 |
| EP2819995B1 (en) | 2012-02-27 | 2017-02-01 | Olatec Therapeutics LLC | Process for preparing 3-methylsulfonylpropionitrile |
| BR112014030288A8 (pt) | 2012-06-05 | 2021-06-22 | Olatec Ind Llc | composição farmacêutica, uso da mesma, e, uso de metanossulfonilacetonitrila |
| WO2013188214A1 (en) | 2012-06-11 | 2013-12-19 | Olatec Industries Llc | Compounds for treating inflammation and pain |
| US9114122B2 (en) | 2012-06-14 | 2015-08-25 | Olatec Industries Llc | Compounds for treating inflammation and pain |
| CN107253935B (zh) | 2012-07-09 | 2020-10-09 | 日本瑞翁株式会社 | 肼化合物、聚合性化合物的制备方法及将肼化合物作为聚合性化合物的制造原料使用的方法 |
| US10273322B2 (en) * | 2013-08-22 | 2019-04-30 | Zeon Corporation | Polymerizable compound, polymerizable composition, polymer, and optical anisotropic body |
| US9999610B2 (en) | 2013-10-01 | 2018-06-19 | Olatec Therapeutics Llc | Pharmaceutical use of 3-benzylsulfonylpropionitrile |
| WO2015050878A1 (en) * | 2013-10-01 | 2015-04-09 | Olatec Industries Llc | Pharmaceutical use of 3-benzylsulfonylpropionitrile |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5512427B2 (es) * | 1971-12-29 | 1980-04-02 | ||
| US3937714A (en) * | 1972-10-10 | 1976-02-10 | Eli Lilly And Company | Exchange amination process for preparing 2-hydrazinobenzothiazoles |
| JPS49135125A (es) * | 1973-05-01 | 1974-12-26 | ||
| DE2340571C3 (de) * | 1973-08-10 | 1982-01-21 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von heterocyclischen Verbindungen |
| US4178451A (en) * | 1978-07-13 | 1979-12-11 | E. R. Squibb & Sons, Inc. | 3-(Substituted hydrazino)benzisothiazole-1,1-dioxides |
| US4319026A (en) * | 1980-08-14 | 1982-03-09 | Gulf Oil Corporation | Heterocyclic-substituted hydrazides and hydrazones as plant growth regulators |
| US4387318A (en) * | 1981-06-04 | 1983-06-07 | Piezo Electric Products, Inc. | Piezoelectric fluid-electric generator |
-
1982
- 1982-09-20 GB GB08304419A patent/GB2116964B/en not_active Expired
- 1982-09-20 JP JP57503185A patent/JPS58501722A/ja active Pending
- 1982-09-20 AU AU89993/82A patent/AU553775B2/en not_active Ceased
- 1982-09-20 CH CH3079/83A patent/CH654573A5/de not_active IP Right Cessation
- 1982-09-20 NL NL8220390A patent/NL8220390A/nl unknown
- 1982-09-20 DE DE823249054T patent/DE3249054T1/de not_active Withdrawn
- 1982-09-20 EP EP82903204A patent/EP0091468B1/en not_active Expired
- 1982-09-20 WO PCT/US1982/001296 patent/WO1983001448A1/en active IP Right Grant
- 1982-10-04 NZ NZ202071A patent/NZ202071A/en unknown
- 1982-10-05 ZA ZA827307A patent/ZA827307B/xx unknown
- 1982-10-05 CA CA000412861A patent/CA1183540A/en not_active Expired
- 1982-10-07 PH PH27960A patent/PH17577A/en unknown
- 1982-10-11 GR GR69498A patent/GR77022B/el unknown
- 1982-10-14 PT PT75676A patent/PT75676B/pt unknown
- 1982-10-14 ES ES516508A patent/ES8401047A1/es not_active Expired
- 1982-10-15 IT IT23780/82A patent/IT1191037B/it active
-
1983
- 1983-03-03 US US06/471,926 patent/US4476137A/en not_active Expired - Fee Related
- 1983-03-23 SE SE8301608A patent/SE454175B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1983001448A1 (en) | 1983-04-28 |
| IT8223780A0 (it) | 1982-10-15 |
| US4476137A (en) | 1984-10-09 |
| AU8999382A (en) | 1983-05-05 |
| IT1191037B (it) | 1988-02-24 |
| GB2116964A (en) | 1983-10-05 |
| ES516508A0 (es) | 1983-11-16 |
| CH654573A5 (de) | 1986-02-28 |
| JPS58501722A (ja) | 1983-10-13 |
| GB8304419D0 (en) | 1983-03-23 |
| GB2116964B (en) | 1985-07-17 |
| PT75676A (en) | 1982-11-01 |
| AU553775B2 (en) | 1986-07-24 |
| SE454175B (sv) | 1988-04-11 |
| NZ202071A (en) | 1985-12-13 |
| PT75676B (en) | 1985-07-26 |
| SE8301608L (sv) | 1983-04-17 |
| PH17577A (en) | 1984-10-01 |
| SE8301608D0 (sv) | 1983-03-23 |
| EP0091468A1 (en) | 1983-10-19 |
| CA1183540A (en) | 1985-03-05 |
| GR77022B (es) | 1984-09-04 |
| DE3249054T1 (de) | 1983-11-17 |
| EP0091468A4 (en) | 1985-07-01 |
| EP0091468B1 (en) | 1987-08-19 |
| NL8220390A (nl) | 1983-08-01 |
| ZA827307B (en) | 1983-08-31 |
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