ES8400441A1 - "procedimiento para la produccion de 1-azaxantona". - Google Patents

"procedimiento para la produccion de 1-azaxantona".

Info

Publication number
ES8400441A1
ES8400441A1 ES515897A ES515897A ES8400441A1 ES 8400441 A1 ES8400441 A1 ES 8400441A1 ES 515897 A ES515897 A ES 515897A ES 515897 A ES515897 A ES 515897A ES 8400441 A1 ES8400441 A1 ES 8400441A1
Authority
ES
Spain
Prior art keywords
azaxanthone
processes
production
pharmaceutical compositions
therapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515897A
Other languages
English (en)
Other versions
ES515897A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lacer SA
Original Assignee
Lacer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer SA filed Critical Lacer SA
Publication of ES8400441A1 publication Critical patent/ES8400441A1/es
Publication of ES515897A0 publication Critical patent/ES515897A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 1-AZAXANTONA.CONSISTE EN LA REACCION DE CICLIZACION DE ACIDO 2-FENOXINICOTINICO POR CALENTAMIENTO A UNA TEMPERATURA ENTRE 160JC Y 200JC EN PRESENCIA DE ACIDO POLIFOSFORICO COMO AGENTE DESHIDRATANTE. LA REACCION SE LLEVA A CABO AÑADIENDO EL ACIDO 2-FENOXINICOTINICO SOBRE 5-10 VECES SU PESO DE ACIDO POLIFOSFORICO DE 80-85, EXPRESADO EN P2O5, PREVIAMENTE CALENTADO. LA MEZCLA DE REACCION SE DILUYE CON AGUA, SE NEUTRALIZA HASTA PH 2-3 CON ALCALI Y SE SEPARA DE LA 1-AZAXANTONA.LA 1-AZAXANTONA TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANALGESICA, ANTIPIRETICA,ANTIINFLAMATORIA, ESPASMOLITICA, BRONCODILATADORA Y DIURETICA.
ES515897A 1981-09-25 1982-09-23 "procedimiento para la produccion de 1-azaxantona". Granted ES515897A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP81107651A EP0075607B1 (en) 1981-09-25 1981-09-25 1-azaxanthone for use as therapeutic agent, processes for its production and pharmaceutical compositions

Publications (2)

Publication Number Publication Date
ES8400441A1 true ES8400441A1 (es) 1983-11-16
ES515897A0 ES515897A0 (es) 1983-11-16

Family

ID=8187931

Family Applications (2)

Application Number Title Priority Date Filing Date
ES515897A Granted ES515897A0 (es) 1981-09-25 1982-09-23 "procedimiento para la produccion de 1-azaxantona".
ES515898A Granted ES515898A0 (es) 1981-09-25 1982-09-23 "procedimiento para la produccion de 1-azaxantona".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES515898A Granted ES515898A0 (es) 1981-09-25 1982-09-23 "procedimiento para la produccion de 1-azaxantona".

Country Status (7)

Country Link
US (1) US4623648A (es)
EP (1) EP0075607B1 (es)
JP (1) JPS5867618A (es)
AT (1) ATE12072T1 (es)
DE (1) DE3169269D1 (es)
ES (2) ES515897A0 (es)
PT (2) PT75582A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE902790A (fr) * 1984-07-12 1986-01-02 Sandoz Sa Procede de preparation de xanthones et de thioxanthones.
US5565413A (en) * 1994-12-06 1996-10-15 Zeneca Limited Substituted pyridyl phenyl ketone herbicides
EP0996436B1 (en) * 1997-03-03 2005-07-27 Sanofi-Aventis Pharmaceutical formulations containing poorly soluble drug substances
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803153A (en) 1970-11-16 1974-04-09 Schering Corp Benzopyrano pyridines
JPS5619350B2 (es) * 1972-07-21 1981-05-07
JPS5919113B2 (ja) * 1975-02-03 1984-05-02 ウェルファイド株式会社 新規なベンゾピラノピリジン誘導体の製法
JPS5195097A (ja) * 1975-02-08 1976-08-20 Benzopiranopirijinjudotainoseizoho

Also Published As

Publication number Publication date
ES8308886A1 (es) 1983-10-16
EP0075607A1 (en) 1983-04-06
JPS5867618A (ja) 1983-04-22
ES515898A0 (es) 1983-10-16
PT75582A (fr) 1982-10-01
DE3169269D1 (en) 1985-04-18
EP0075607B1 (en) 1985-03-13
PT75581B (fr) 1985-05-31
JPH0354645B2 (es) 1991-08-20
ES515897A0 (es) 1983-11-16
ATE12072T1 (de) 1985-03-15
PT75581A (fr) 1982-10-01
US4623648A (en) 1986-11-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519