BR9808136A - Formulações farmacêuticas contendo substâncias medicamentosas fracamente solúveis. - Google Patents

Formulações farmacêuticas contendo substâncias medicamentosas fracamente solúveis.

Info

Publication number
BR9808136A
BR9808136A BR9808136-5A BR9808136A BR9808136A BR 9808136 A BR9808136 A BR 9808136A BR 9808136 A BR9808136 A BR 9808136A BR 9808136 A BR9808136 A BR 9808136A
Authority
BR
Brazil
Prior art keywords
poorly soluble
soluble drug
drug substances
pharmaceutical formulations
formulations containing
Prior art date
Application number
BR9808136-5A
Other languages
English (en)
Inventor
William L Rocco
Sharon M Laughlin
Nancy M Franson
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/808,761 external-priority patent/US5760056A/en
Priority claimed from US08/813,946 external-priority patent/US5837714A/en
Priority claimed from US08/810,560 external-priority patent/US5776987A/en
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of BR9808136A publication Critical patent/BR9808136A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Patente de Invenção: <B>"FORMULAçõES FARMACêUTICAS CONTENDO SUBSTâNCIAS MEDICAMENTOSAS FRACAMENTE SOLúVEIS"<D>. São fornecidas formulações farmacêuticas de substâncias de drogas fracamente solúveis sob a forma de soluções concentradas para enchimento de cápsulas de gelatina macia; dispersões sólidas e suspensões para enchimento de cápsulas de gelatina dura. O sistema solvente usado inclui xilitol, diidrato de fosfato dicálcico, monodrato de lactose, celulose microcristalina, propileno glicol e NaOH.
BR9808136-5A 1997-03-03 1998-02-27 Formulações farmacêuticas contendo substâncias medicamentosas fracamente solúveis. BR9808136A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/808,761 US5760056A (en) 1997-03-03 1997-03-03 Pharmaceutical formulation
US08/813,946 US5837714A (en) 1997-03-03 1997-03-03 Solid pharmaceutical dispersions
US08/810,560 US5776987A (en) 1997-03-03 1997-03-03 Pharmaceutical suspension formulation
US2850498A 1998-02-24 1998-02-24
PCT/US1998/004078 WO1998038987A1 (en) 1997-03-03 1998-02-27 Pharmaceutical formulations containing poorly soluble drug substances

Publications (1)

Publication Number Publication Date
BR9808136A true BR9808136A (pt) 2000-03-28

Family

ID=27487679

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9808136-5A BR9808136A (pt) 1997-03-03 1998-02-27 Formulações farmacêuticas contendo substâncias medicamentosas fracamente solúveis.

Country Status (10)

Country Link
EP (1) EP0996436B1 (pt)
JP (2) JP4510156B2 (pt)
AT (1) ATE300293T1 (pt)
BR (1) BR9808136A (pt)
CA (1) CA2281946C (pt)
DE (1) DE69830997T2 (pt)
ES (1) ES2242273T3 (pt)
HR (1) HRP980105A2 (pt)
NO (1) NO325726B1 (pt)
WO (1) WO1998038987A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197787B1 (en) 1997-03-03 2001-03-06 Sanofi-Synthelabo Pharmaceutical formulations containing poorly soluble drug substances
US6342249B1 (en) 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
IL143846A0 (en) * 1998-12-23 2002-04-21 Alza Corp Dosage forms comprising porous particles
US6387400B1 (en) * 2000-08-29 2002-05-14 R.P. Scherer Technologies, Inc. Process for preparing pharmaceutical compositions for use with soft gelatin formulations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE12072T1 (de) * 1981-09-25 1985-03-15 Lacer Sa 1-azaxanthon zur therapeutischen verwendung, verfahren zu seiner herstellung und pharmazeutische zusammensetzungen.
US4725427A (en) * 1984-03-13 1988-02-16 Albion International, Inc. Effervescent vitamin-mineral granule preparation
US5071643A (en) * 1986-10-17 1991-12-10 R. P. Scherer Corporation Solvent system enhancing the solubility of pharmaceuticals for encapsulation
DD293499A5 (de) * 1989-06-06 1991-09-05 Arzneimittelwerk Dresden Gmbh,De Verfahren zur herstellung cyclosporinhaltiger galenischer formulierungen
FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
PL171158B1 (pl) * 1991-11-04 1997-03-28 Fuisz Technologies Ltd Kompozycja do dostarczania cieczy hydrofobowych o zdolnosci szybkiego ich uwalniani oraz sposób wytwarzania kompozycji do dostarczania cieczy hydrofobowych PL
JP3121080B2 (ja) * 1991-12-19 2000-12-25 アール・ピー・シーラー コーポレイション カプセル封入用溶液
US5376688A (en) * 1992-12-18 1994-12-27 R. P. Scherer Corporation Enhanced solubility pharmaceutical solutions
GB9302720D0 (en) * 1993-02-11 1993-03-24 Scherer Ltd R P Products in capsule form for use in aqueous solution

Also Published As

Publication number Publication date
DE69830997T2 (de) 2006-02-09
JP5563260B2 (ja) 2014-07-30
ES2242273T3 (es) 2005-11-01
HRP980105A2 (en) 1999-02-28
NO994249L (no) 1999-11-03
JP2009286798A (ja) 2009-12-10
DE69830997D1 (de) 2005-09-01
CA2281946A1 (en) 1998-09-11
JP4510156B2 (ja) 2010-07-21
ATE300293T1 (de) 2005-08-15
NO994249D0 (no) 1999-09-02
EP0996436A1 (en) 2000-05-03
EP0996436A4 (en) 2001-04-11
CA2281946C (en) 2007-08-07
EP0996436B1 (en) 2005-07-27
WO1998038987A1 (en) 1998-09-11
NO325726B1 (no) 2008-07-07
JP2002513406A (ja) 2002-05-08

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AOS REQUISITOS DOS ARTIGOS 8, 13, 24 E 25 DA LPI.