ES8308877A1 - Procedimiento para la obtencion de derivados del acido 2-(3'-hidroxi-pirid-2'-il)-2-tiazolin-4-carboxilico. - Google Patents

Procedimiento para la obtencion de derivados del acido 2-(3'-hidroxi-pirid-2'-il)-2-tiazolin-4-carboxilico.

Info

Publication number
ES8308877A1
ES8308877A1 ES514587A ES514587A ES8308877A1 ES 8308877 A1 ES8308877 A1 ES 8308877A1 ES 514587 A ES514587 A ES 514587A ES 514587 A ES514587 A ES 514587A ES 8308877 A1 ES8308877 A1 ES 8308877A1
Authority
ES
Spain
Prior art keywords
compounds
formula
processes
carbocyclic
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514587A
Other languages
English (en)
Other versions
ES514587A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8308877A1 publication Critical patent/ES8308877A1/es
Publication of ES514587A0 publication Critical patent/ES514587A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/167—Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/48—Streptomyces antibioticus ; Actinomyces antibioticus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL ACIDO 2-(3 -HIDROXIPIRID-2 -IL)-2-TIAZOLIN-4-CARBOXILICO. CONSISTE EN RETIRAR UN PROTON DE UN COMPUESTO (I) EN QUE R>3 ES HIDROGENO Y EL PRODUCTO INTERMEDIO OBTENIDO SE HACE REACCIONAR CON UN AGENTE DE ALQUILACION TRANSMISOR DEL RESTO R>3, EN EL QUE EL ATOMO DE CARBONO ALQUILO, QUE FORMA EL NUEVO ENLACE, ELEVE UNA CARGA PARCIAL POSITIVA. EN EL COMPUESTO OBTENIDO (I), R>1 SIGNIFICA HIDROXI LIBRE ETERADO O ESTERIFICADO; R>2 ES HIDROGENO O UN RESTO ALIFATICO, CARBOCICLICO O CARBOCICLICO-ALIFATICO Y R>3 ES UN RESTO ALIFATICO INSUSTITUIDO CON 1-7 ATOMO DE CARBONO. OPCIONALMENTE SE OBTIENEN LAS SALES O LOS COMPLEJOS DE ION METALICO CORRESPONDIENTES.
ES514587A 1980-07-28 1982-07-30 Procedimiento para la obtencion de derivados del acido 2-(3'-hidroxi-pirid-2'-il)-2-tiazolin-4-carboxilico. Granted ES514587A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH575580 1980-07-28
CH592580 1980-08-05

Publications (2)

Publication Number Publication Date
ES8308877A1 true ES8308877A1 (es) 1983-10-01
ES514587A0 ES514587A0 (es) 1983-10-01

Family

ID=25698328

Family Applications (4)

Application Number Title Priority Date Filing Date
ES504316A Granted ES504316A0 (es) 1980-07-28 1981-07-27 Procedimiento para la obtencion de derivados del acido 2-(3'-hidroxipirid-2'-il)-2-tiazolin-4-carboxilico
ES514588A Expired ES8308878A1 (es) 1980-07-28 1982-07-30 Procedimiento para la obtencion de derivados del acido 2-(3'-hidroxi-pirid-2'-il)-2-tiazolin-4-carboxilico.
ES514587A Granted ES514587A0 (es) 1980-07-28 1982-07-30 Procedimiento para la obtencion de derivados del acido 2-(3'-hidroxi-pirid-2'-il)-2-tiazolin-4-carboxilico.
ES514586A Expired ES8400425A1 (es) 1980-07-28 1982-07-30 Procedimiento para la obtencion de derivados del acido 2-(3'-hidroxi-pirid-2'-il)-2-tiazolin-4-carboxilico.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES504316A Granted ES504316A0 (es) 1980-07-28 1981-07-27 Procedimiento para la obtencion de derivados del acido 2-(3'-hidroxipirid-2'-il)-2-tiazolin-4-carboxilico
ES514588A Expired ES8308878A1 (es) 1980-07-28 1982-07-30 Procedimiento para la obtencion de derivados del acido 2-(3'-hidroxi-pirid-2'-il)-2-tiazolin-4-carboxilico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES514586A Expired ES8400425A1 (es) 1980-07-28 1982-07-30 Procedimiento para la obtencion de derivados del acido 2-(3'-hidroxi-pirid-2'-il)-2-tiazolin-4-carboxilico.

Country Status (13)

Country Link
US (1) US4406905A (es)
EP (1) EP0045281B1 (es)
AU (1) AU548331B2 (es)
CA (1) CA1172188A (es)
DE (1) DE3170401D1 (es)
DK (1) DK160304C (es)
ES (4) ES504316A0 (es)
GB (1) GB2085873B (es)
GR (1) GR74313B (es)
IE (1) IE51430B1 (es)
IL (1) IL63428A (es)
NZ (1) NZ197840A (es)
PT (1) PT73439B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU200177B (en) * 1985-06-18 1990-04-28 Biogal Gyogyszergyar Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds
JPS63225373A (ja) * 1986-07-24 1988-09-20 Sumitomo Pharmaceut Co Ltd 新規チアゾリジン−４−オン誘導体およびその酸付加塩
CN1030415A (zh) * 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
US4992455A (en) * 1987-05-22 1991-02-12 Sumitomo Pharmaceuticals Company, Limited Thiazolidin-4-one derivatives useful for treating diseases caused by platelet activating factor
EP0325559B1 (de) * 1988-01-20 1993-12-15 Ciba-Geigy Ag Verfahren zur Herstellung von Komplexverbindungen
US5021435A (en) * 1988-01-22 1991-06-04 Sumitomo Pharmaceuticals Company, Limited Certain pyridyl-thiazolidin-4-one having anti-ulcer activity
AU5602594A (en) * 1992-11-16 1994-06-08 University Of Florida Research Foundation, Inc. 2-(pyrid-2'-yl)-2-thiazoline-4(s)-carboxylic acid derivatives
US5840739A (en) * 1992-11-16 1998-11-24 University Of Florida Research Foundation, Inc. Thiazoline acid derivatives
CA2173342A1 (en) * 1994-08-05 1996-02-15 Reiji Takeda New antibiotics and process for preparation therefor
US6083966A (en) 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
CN1585639A (zh) * 1998-09-21 2005-02-23 佛罗里达大学研究基金会 抗疟疾制剂
AT500490A1 (de) * 2001-10-16 2006-01-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte
WO2003097622A2 (en) * 2002-05-15 2003-11-27 Genzyme Corporation Synthesis of 2-alkylcysteines, 2-(hydroxylated phenyl)-4-alkylthiazoline-4-carboxylic acids and derivatives thereof
AU2003268706A1 (en) * 2002-10-01 2004-04-23 Kaneka Corporation PROCESS FOR PRODUCING OPTICALLY ACTIVE Alpha-SUBSTITUTED CYSTEINE OR SALT THEREOF, INTERMEDIATE THEREFOR, AND PROCESS FOR PRODUCING THE SAME
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
BRPI0610644B8 (pt) * 2005-04-04 2021-05-25 Univ Florida composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável.
CN104003955A (zh) * 2007-03-15 2014-08-27 佛罗里达大学研究基金公司 去铁硫辛聚醚类似物
CA2859406C (en) 2011-12-16 2020-08-25 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
USD722879S1 (en) 2012-06-14 2015-02-24 S.C. Johnson & Son, Inc. Bottle
USD736089S1 (en) 2012-06-14 2015-08-11 S.C. Johnson & Son, Inc. Bottle
USD736637S1 (en) 2012-06-14 2015-08-18 S.C. Johnson & Son, Inc. Bottle
JP6838966B2 (ja) 2013-11-22 2021-03-03 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． デスフェリチオシン類似体およびその使用
KR102418462B1 (ko) 2014-07-08 2022-07-08 코르테바 애그리사이언스 엘엘씨 3―히드록시피콜린산 제조 방법
TWI682923B (zh) * 2014-07-08 2020-01-21 美商陶氏農業科學公司 用於製備４-烷氧基-３-羥基吡啶甲酸之方法
CN107708693A (zh) 2015-04-27 2018-02-16 佛罗里达大学研究基金会 代谢程序化的金属螯合剂及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592905A (en) * 1969-10-30 1971-07-13 Merck & Co Inc Therapeutic methods
CA962269A (en) * 1971-05-05 1975-02-04 Robert E. Grahame (Jr.) Thiazoles, and their use as insecticides
US3852293A (en) * 1972-06-21 1974-12-03 Uniroyal Inc 4-phenyl-2-(3-pyridyl)-thiazole carboxamides
US3842172A (en) * 1972-10-06 1974-10-15 Uniroyal Inc Pharmaceutical compositions containing a 4-substituted-2-(3-pyridyl)thiazole and methods of using same
FR2356423A1 (fr) * 1976-07-01 1978-01-27 Oeriu Simion Derives de l'acide thiazolidinecarboxylique, leur preparation et leur application comme medicaments

Also Published As

Publication number Publication date
DK160304C (da) 1991-07-29
PT73439A (de) 1981-08-01
AU7343981A (en) 1982-02-04
IE51430B1 (en) 1986-12-24
ES514587A0 (es) 1983-10-01
US4406905A (en) 1983-09-27
IE811697L (en) 1982-01-28
NZ197840A (en) 1985-08-30
GB2085873B (en) 1984-03-21
ES514588A0 (es) 1983-10-01
CA1172188A (en) 1984-08-07
ES514586A0 (es) 1983-11-01
AU548331B2 (en) 1985-12-05
DE3170401D1 (en) 1985-06-13
DK160304B (da) 1991-02-25
PT73439B (de) 1983-06-20
GR74313B (es) 1984-06-22
IL63428A (en) 1984-12-31
ES8301476A1 (es) 1982-12-01
ES504316A0 (es) 1982-12-01
IL63428A0 (en) 1981-10-30
ES8308878A1 (es) 1983-10-01
DK335781A (da) 1982-01-29
ES8400425A1 (es) 1983-11-01
GB2085873A (en) 1982-05-06
EP0045281A1 (de) 1982-02-03
EP0045281B1 (de) 1985-05-08

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20000201