ES8205861A1 - Procedimiento para la preparacion de un preparado estabili- zado de trombina - Google Patents

Procedimiento para la preparacion de un preparado estabili- zado de trombina

Info

Publication number
ES8205861A1
ES8205861A1 ES501365A ES501365A ES8205861A1 ES 8205861 A1 ES8205861 A1 ES 8205861A1 ES 501365 A ES501365 A ES 501365A ES 501365 A ES501365 A ES 501365A ES 8205861 A1 ES8205861 A1 ES 8205861A1
Authority
ES
Spain
Prior art keywords
thrombin preparation
stabilized thrombin
stabilized
preparation
stabilizer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501365A
Other languages
English (en)
Other versions
ES501365A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of ES8205861A1 publication Critical patent/ES8205861A1/es
Publication of ES501365A0 publication Critical patent/ES501365A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8114—Kunitz type inhibitors
    • G01N2333/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

PROCEDIMIENTO PARA OBTENER UN PREPARADO ESTABILIZADO DE TROMBINA. A LA SOLUCION DE TROMBINA SE LE AÑADEN COMO ESTABILIZADORES DE 5 A 100 MG ML. DE ALBUMINA SE SUERO EN COMBINACION CON, AL MENOS, UN FORMADOR DE QUELATOS 0,01 S 0,2 M, UTILIZANDOSE CON ESTE FIN LIGANDOS HEXADENTADOS TAL COMO ACIDO ETILENDIAMINO TETRAACETICO. SE PROSIGUE LA REACCION HASTA EL ESTABLECIMIENTO DE UN EQUILIBRIO ESTABLE Y EVENTUALMENTE SE LIOFILIZA LA SOLUCION OBTENIDA. SE UTILIZA CON FINES DIAGNOSTICOS.
ES501365A 1980-05-22 1981-04-14 Procedimiento para la preparacion de un preparado estabili- zado de trombina Granted ES501365A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803019612 DE3019612A1 (de) 1980-05-22 1980-05-22 Stabilisiertes thrombinpraeparat

Publications (2)

Publication Number Publication Date
ES8205861A1 true ES8205861A1 (es) 1982-08-16
ES501365A0 ES501365A0 (es) 1982-08-16

Family

ID=6103084

Family Applications (1)

Application Number Title Priority Date Filing Date
ES501365A Granted ES501365A0 (es) 1980-05-22 1981-04-14 Procedimiento para la preparacion de un preparado estabili- zado de trombina

Country Status (7)

Country Link
US (1) US4409334A (es)
EP (1) EP0040799B1 (es)
JP (1) JPS5826956B2 (es)
AT (1) ATE5150T1 (es)
DD (1) DD158857A5 (es)
DE (2) DE3019612A1 (es)
ES (1) ES501365A0 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58220697A (ja) * 1982-06-15 1983-12-22 Green Cross Corp:The アンテイトロンビン−３の活性測定方法及びその方法を使用するキツト
DE3413311A1 (de) * 1984-04-09 1985-10-17 Behringwerke Ag, 3550 Marburg Reagenz zur bestimmung der thromboplastinzeit
US4613574A (en) * 1984-05-04 1986-09-23 Preventive Diagnostics Corporation In vitro test for ocular toxic properties
DE3637253A1 (de) * 1986-11-03 1988-05-05 Behringwerke Ag Latex-agglutinations-verfahren zum nachweis von anti-streptokokken-desoxyribonuclease b
IL87327A0 (en) * 1987-09-03 1989-01-31 Technicon Instr Aqueous enzyme compositions comprising proteolytic inhibitors as stabilizers
US5939325A (en) * 1989-07-20 1999-08-17 Analytical Control Systems, Inc. Stable whole blood coagulation controls
DE69033033T2 (de) * 1989-07-20 1999-10-28 Analytical Control Syst Inc Verbesserte kontrollverfahren für stabile blutkoagulation
US5646046A (en) * 1989-12-01 1997-07-08 Akzo Nobel N.V. Method and instrument for automatically performing analysis relating to thrombosis and hemostasis
US5068181A (en) * 1989-12-01 1991-11-26 Akzo N.V. Method of monitoring reagent delivery in a scanning spectrophotometer
DE3942081A1 (de) * 1989-12-20 1991-06-27 Behringwerke Ag Mittel zur verbesserung der wiederfindung von annexinen
US5212081A (en) * 1990-04-03 1993-05-18 Microgenics Corporation Stabilization of polypeptide fragments against proteolytic degradation
AT398079B (de) * 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
US5385825A (en) * 1993-07-20 1995-01-31 Emerald Biomedical Sciences, Inc. Composition for processing bodyfluids, method of processing bodyfluids and products made from bodyfluids
RU2193897C2 (ru) * 1996-04-04 2002-12-10 Бакстер Акциенгезельшафт Гемостатическая губка, основанная на коллагене, способ ее получения, повязка для ран, включающая такую губку, и набор для приготовления повязки для ран
US6274553B1 (en) 1997-01-20 2001-08-14 Japan Energy Corporation Method for stabilizing peptides and freeze-dried medicinal compositions containing peptides obtained by using the method
DE19855819C2 (de) 1998-12-03 2001-02-15 Roche Diagnostics Gmbh Stabilisierung von Cytokeratin enthaltenden Kalibratoren
EP1221479B1 (en) * 1999-09-27 2006-11-22 Sysmex Corporation Method for stabilizing thrombin
DE10012732A1 (de) 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
JP5044829B2 (ja) * 2003-12-31 2012-10-10 ザ ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム トロンビンペプチド誘導体のための医薬組成物
AU2007264735B2 (en) * 2006-06-26 2012-11-08 Omrix Biopharmaceuticals Inc. Virus removal by nanofiltration
IL229134A0 (en) 2013-10-29 2014-03-31 Omrix Biopharmaceuticals Ltd Compounds and methods for stabilizing thrombin activity
IL234246A0 (en) 2014-08-21 2014-11-30 Omrix Biopharmaceuticals Ltd Stabilized thrombin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931399A (en) * 1970-12-22 1976-01-06 Behringwerke Aktiengesellschaft Process for isolating a fibrin-stabilizing factor
DE2234412B2 (de) * 1972-07-13 1980-07-03 Henkel Kgaa, 4000 Duesseldorf Verfahren zur Stabilisierung und Fällung konzentrierter Protease-Lösungen
DE2648759C3 (de) * 1976-10-27 1979-05-31 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilisierungsmittel für Enzyme
DE2807089A1 (de) * 1978-02-20 1979-08-23 Degussa Verwendung von proteinen zur stabilisierung von lipase nicht-tierischen ursprungs in arzneizubereitungen
DE2812943C3 (de) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma
US4195072A (en) * 1978-07-05 1980-03-25 Abbott Laboratories Stabilized platelet factor 4 immunoassay standards
DE2903701C2 (de) * 1979-01-31 1980-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Kontrollreagens für die Bestimmung der Heparinaktivität

Also Published As

Publication number Publication date
DE3161270D1 (en) 1983-12-01
JPS5826956B2 (ja) 1983-06-06
EP0040799B1 (de) 1983-10-26
EP0040799A3 (en) 1982-01-13
US4409334A (en) 1983-10-11
ATE5150T1 (de) 1983-11-15
DE3019612A1 (de) 1981-11-26
JPS5718985A (en) 1982-01-30
DD158857A5 (de) 1983-02-09
EP0040799A2 (de) 1981-12-02
ES501365A0 (es) 1982-08-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990405