ES8205406A1 - Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina. - Google Patents
Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina.Info
- Publication number
- ES8205406A1 ES8205406A1 ES500055A ES500055A ES8205406A1 ES 8205406 A1 ES8205406 A1 ES 8205406A1 ES 500055 A ES500055 A ES 500055A ES 500055 A ES500055 A ES 500055A ES 8205406 A1 ES8205406 A1 ES 8205406A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- present
- aralkyl
- alkyl
- represent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 4
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 title abstract 2
- YJGVMLPVUAXIQN-HAEOHBJNSA-N picropodophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-HAEOHBJNSA-N 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000006575 electron-withdrawing group Chemical group 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- XHLHPRDBBAGVEG-UHFFFAOYSA-N 1-tetralone Chemical compound C1=CC=C2C(=O)CCCC2=C1 XHLHPRDBBAGVEG-UHFFFAOYSA-N 0.000 abstract 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- -1 aralkoxy Chemical group 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/127,436 US4294763A (en) | 1980-03-05 | 1980-03-05 | Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8205406A1 true ES8205406A1 (es) | 1982-06-01 |
| ES500055A0 ES500055A0 (es) | 1982-06-01 |
Family
ID=22430103
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES500056A Expired ES8205407A1 (es) | 1980-03-05 | 1981-03-04 | Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina. |
| ES500055A Granted ES500055A0 (es) | 1980-03-05 | 1981-03-04 | Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina. |
| ES500051A Expired ES8205408A1 (es) | 1980-03-05 | 1981-03-04 | Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES500056A Expired ES8205407A1 (es) | 1980-03-05 | 1981-03-04 | Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES500051A Expired ES8205408A1 (es) | 1980-03-05 | 1981-03-04 | Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4294763A (enExample) |
| JP (2) | JPS572229A (enExample) |
| CA (1) | CA1181083A (enExample) |
| CH (2) | CH657363A5 (enExample) |
| DE (2) | DE3153681C2 (enExample) |
| ES (3) | ES8205407A1 (enExample) |
| GB (2) | GB2070609B (enExample) |
| IT (1) | IT1212502B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4708964A (en) * | 1984-02-09 | 1987-11-24 | Chemex Pharmaceuticals | Lipoxygenase inhibitors |
| US4795819A (en) * | 1985-04-12 | 1989-01-03 | Bristol-Myers Company | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof |
| US4644072A (en) * | 1985-04-12 | 1987-02-17 | Bristol-Myers Company | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof |
| US4866189A (en) * | 1985-04-12 | 1989-09-12 | Bristol-Myers Company | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof |
| US4734512A (en) * | 1985-12-05 | 1988-03-29 | Bristol-Myers Company | Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof |
| US5106996A (en) * | 1985-12-05 | 1992-04-21 | Bristol-Myers Company | Process for the preparation of podophyllotoxin |
| US5013851A (en) * | 1985-12-05 | 1991-05-07 | Bristol-Myers Company | Intermediates for the production of podophyllotoxin and related compounds |
| JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
| CA2789262C (en) | 2005-04-28 | 2016-10-04 | Proteus Digital Health, Inc. | Pharma-informatics system |
| US8795627B2 (en) | 2007-03-21 | 2014-08-05 | Raptor Pharmaceuticals Inc. | Treatment of liver disorders by administration of RAP conjugates |
| WO2009100349A1 (en) * | 2008-02-09 | 2009-08-13 | The Trustees Of Columbia University In The City Of New York | Analogues of (-)-picropodophyllin, synthesis and uses thereof |
| ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
| CN110075069A (zh) | 2009-05-06 | 2019-08-02 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1088621A (en) | 1963-12-12 | 1967-10-25 | Sandoz Ltd | Improvements in or relating to podophyllin derivatives |
| NL6613143A (enExample) * | 1965-09-21 | 1967-03-22 | ||
| US4122092A (en) * | 1977-08-25 | 1978-10-24 | University Of Rochester | Total synthesis of (±)-picropodophyllone and (±)-4'-demethylpicropodophyllone |
-
1980
- 1980-03-05 US US06/127,436 patent/US4294763A/en not_active Expired - Lifetime
-
1981
- 1981-02-23 DE DE3153681A patent/DE3153681C2/de not_active Expired - Lifetime
- 1981-02-23 DE DE19813106674 patent/DE3106674A1/de active Granted
- 1981-02-27 CH CH5351/84A patent/CH657363A5/de not_active IP Right Cessation
- 1981-02-27 CH CH1350/81A patent/CH655303A5/de not_active IP Right Cessation
- 1981-03-02 JP JP2978981A patent/JPS572229A/ja active Granted
- 1981-03-03 CA CA000372161A patent/CA1181083A/en not_active Expired
- 1981-03-04 ES ES500056A patent/ES8205407A1/es not_active Expired
- 1981-03-04 GB GB8106755A patent/GB2070609B/en not_active Expired
- 1981-03-04 ES ES500055A patent/ES500055A0/es active Granted
- 1981-03-04 ES ES500051A patent/ES8205408A1/es not_active Expired
- 1981-03-05 IT IT8120148A patent/IT1212502B/it active
-
1983
- 1983-03-28 GB GB08308455A patent/GB2116182B/en not_active Expired
-
1988
- 1988-07-05 JP JP88167623A patent/JPH01199929A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES500051A0 (es) | 1982-06-01 |
| CH655303A5 (de) | 1986-04-15 |
| US4294763A (en) | 1981-10-13 |
| JPH0148272B2 (enExample) | 1989-10-18 |
| DE3153681C2 (enExample) | 1992-07-09 |
| CA1181083A (en) | 1985-01-15 |
| CH657363A5 (de) | 1986-08-29 |
| ES500056A0 (es) | 1982-06-01 |
| ES8205407A1 (es) | 1982-06-01 |
| DE3106674A1 (de) | 1981-12-17 |
| GB2116182A (en) | 1983-09-21 |
| GB2070609B (en) | 1984-08-08 |
| GB8308455D0 (en) | 1983-05-05 |
| ES8205408A1 (es) | 1982-06-01 |
| GB2116182B (en) | 1984-10-31 |
| IT1212502B (it) | 1989-11-22 |
| ES500055A0 (es) | 1982-06-01 |
| GB2070609A (en) | 1981-09-09 |
| JPH01199929A (ja) | 1989-08-11 |
| DE3106674C2 (enExample) | 1992-06-11 |
| JPS572229A (en) | 1982-01-07 |
| IT8120148A0 (it) | 1981-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970203 |