ES8202550A1 - Un procedimiento para la produccion de productos de hidroge-nacion hipocolesterolemicos - Google Patents

Un procedimiento para la produccion de productos de hidroge-nacion hipocolesterolemicos

Info

Publication number
ES8202550A1
ES8202550A1 ES499078A ES499078A ES8202550A1 ES 8202550 A1 ES8202550 A1 ES 8202550A1 ES 499078 A ES499078 A ES 499078A ES 499078 A ES499078 A ES 499078A ES 8202550 A1 ES8202550 A1 ES 8202550A1
Authority
ES
Spain
Prior art keywords
same
formula
double bond
dihydromevinolin
mevinolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499078A
Other languages
English (en)
Spanish (es)
Other versions
ES499078A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES499078A0 publication Critical patent/ES499078A0/es
Publication of ES8202550A1 publication Critical patent/ES8202550A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES499078A 1980-02-04 1981-02-03 Un procedimiento para la produccion de productos de hidroge-nacion hipocolesterolemicos Expired ES8202550A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11805080A 1980-02-04 1980-02-04

Publications (2)

Publication Number Publication Date
ES499078A0 ES499078A0 (es) 1982-02-01
ES8202550A1 true ES8202550A1 (es) 1982-02-01

Family

ID=22376236

Family Applications (1)

Application Number Title Priority Date Filing Date
ES499078A Expired ES8202550A1 (es) 1980-02-04 1981-02-03 Un procedimiento para la produccion de productos de hidroge-nacion hipocolesterolemicos

Country Status (9)

Country Link
EP (1) EP0033537B1 (OSRAM)
JP (1) JPS56122374A (OSRAM)
AT (1) ATE13534T1 (OSRAM)
DE (1) DE3170666D1 (OSRAM)
DK (1) DK45981A (OSRAM)
ES (1) ES8202550A1 (OSRAM)
GR (1) GR73077B (OSRAM)
IE (1) IE51477B1 (OSRAM)
PT (1) PT72394B (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2739768A (en) * 1954-09-27 1956-03-27 August C Purpura Aircraft having feathering airfoils
AU548996B2 (en) 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
JPS57185274A (en) * 1981-05-07 1982-11-15 Sankyo Co Ltd Tetrahydro-mb-530b and its derivative
JPS57185276A (en) * 1981-05-11 1982-11-15 Sankyo Co Ltd Dihydro-dum-4 and dihydro-isodum-4 and their derivative
DE3480923D1 (de) * 1983-10-11 1990-02-08 Merck & Co Inc Verfahren zur c-methylierung von 2-methylbutyraten.
EP0137444B1 (en) * 1983-10-11 1990-01-31 Merck & Co. Inc. Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-Decahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
US4885314A (en) * 1987-06-29 1989-12-05 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
EP0306210B1 (en) * 1987-09-03 1993-09-29 Merck & Co. Inc. A novel hydrogenation process for the formation of di or tetrahydro hmg-coa reductase inhibitors
US5089523A (en) * 1990-05-11 1992-02-18 E. R. Squibb & Sons, Inc. Fluorinated derivatives of mevinic acids
US5250435A (en) * 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
AR013445A1 (es) * 1997-08-28 2000-12-27 Novartis Ag Antagonistas de lfa-1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (OSRAM) * 1974-06-07 1981-03-18
US4049495A (en) * 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
JPS6026094B2 (ja) * 1978-07-04 1985-06-21 三共株式会社 テトラヒドロｍｌ↓−２３６ｂおよびその誘導体並びにそれを有効成分とする高脂血症治療剤
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation

Also Published As

Publication number Publication date
EP0033537B1 (en) 1985-05-29
GR73077B (OSRAM) 1984-01-31
ES499078A0 (es) 1982-02-01
DK45981A (da) 1981-08-05
PT72394B (en) 1982-09-06
DE3170666D1 (en) 1985-07-04
JPS56122374A (en) 1981-09-25
IE51477B1 (en) 1987-01-07
PT72394A (en) 1981-02-01
IE810168L (en) 1981-08-04
ATE13534T1 (de) 1985-06-15
EP0033537A3 (en) 1982-02-24
JPH0136471B2 (OSRAM) 1989-07-31
EP0033537A2 (en) 1981-08-12

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960401