ES8202539A1 - Procedimiento para la preparacion de nuevos derivados de prostaglandina - Google Patents
Procedimiento para la preparacion de nuevos derivados de prostaglandinaInfo
- Publication number
- ES8202539A1 ES8202539A1 ES490031A ES490031A ES8202539A1 ES 8202539 A1 ES8202539 A1 ES 8202539A1 ES 490031 A ES490031 A ES 490031A ES 490031 A ES490031 A ES 490031A ES 8202539 A1 ES8202539 A1 ES 8202539A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- preparation
- pgi1
- therapeutic application
- keto
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ROUDCKODIMKLNO-CTBSXBMHSA-N 6-oxoprostaglandin E1 Chemical class CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CC(=O)CCCCC(O)=O ROUDCKODIMKLNO-CTBSXBMHSA-N 0.000 title abstract 2
- 101150040663 PGI1 gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE PROSTAGLANDINA DE FORMULA (I). CONSISTENTE EN PREPARAR EL COMPUESTO (I) EN EL QUE R1 ES PREFERENTEMENTE HIDROGENO O UN RADICAL ALCOHILO DE CADENA RECTA O RAMIFICADO CON HASTA OCHO ATOMOS DE CARBONO U ORTROS RADICALES HIDROCARBONADOS, Y R2 ES PREFERENTEMENTE UN CICLOALCOHILO CON 5 HASTA 7 ATOMOS DE CARNPBONO O RADICALES ALCOHILOS DE CADENA RECTA CON 3 HASTA 7 ATOMOS DE CARBONO, ASI COMO RADICALES ALCOHILO RAMIFICADOS QUE PUEDEN ESTAR SUSTITUIDOS CON DIVERSOS GRUPOS. PARA LA OBTENCION DE (I) SE PARTE DE UN COMPUESTO CON ESTRUCTURA BASTANTE SIMILAR, HASTA OBTENER UN COMPUESTO (II) EN EL QUE R3 ES UN GRUPO PROTECTOR FACILMENTE SEPARABLE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19792913856 DE2913856A1 (de) | 1979-04-06 | 1979-04-06 | Neue prostaglandinderivate in der 6-keto-pge tief 1 -reihe |
Publications (2)
Publication Number | Publication Date |
---|---|
ES490031A0 ES490031A0 (es) | 1982-02-01 |
ES8202539A1 true ES8202539A1 (es) | 1982-02-01 |
Family
ID=6067601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES490031A Expired ES8202539A1 (es) | 1979-04-06 | 1980-03-28 | Procedimiento para la preparacion de nuevos derivados de prostaglandina |
Country Status (11)
Country | Link |
---|---|
US (1) | US4304783A (es) |
EP (1) | EP0019069B1 (es) |
JP (1) | JPS55141465A (es) |
AT (1) | ATE8621T1 (es) |
AU (1) | AU544615B2 (es) |
CA (1) | CA1152505A (es) |
DE (2) | DE2913856A1 (es) |
ES (1) | ES8202539A1 (es) |
HU (1) | HU184735B (es) |
IL (1) | IL59768A (es) |
ZA (1) | ZA802011B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3401542A1 (de) * | 1984-01-18 | 1985-08-01 | Merck Patent Gmbh, 6100 Darmstadt | Schwefelhaltige 6-ketoprostaglandine |
JPS60181068A (ja) * | 1984-02-29 | 1985-09-14 | Teijin Ltd | 6−置換プロスタグランジンe↓1類およびその製造法 |
DE3708537A1 (de) * | 1987-03-13 | 1988-09-22 | Schering Ag | 6-oxoprostaglandin-e-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung |
US4791133A (en) * | 1987-06-26 | 1988-12-13 | G. D. Searle & Co. | Phenylene, furyl, and thienyl leukotriene B4 analogues |
US5834498A (en) * | 1992-09-21 | 1998-11-10 | Allergan | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
US6576663B2 (en) | 1999-12-22 | 2003-06-10 | Alcon, Inc. | 6-Keto prostaglandin F1α and analogs for treating dry eye |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU511711B2 (en) * | 1976-12-30 | 1980-09-04 | Upjohn Company, The | 6-Oxo and 5, 6-Dihalo prostaglandin analogues |
US4205178A (en) * | 1976-12-30 | 1980-05-27 | The Upjohn Company | 6-Keto prostaglandin E-type compounds |
JPS6022710B2 (ja) * | 1977-09-16 | 1985-06-03 | 小野薬品工業株式会社 | プロスタグランジン類似化合物 |
-
1979
- 1979-04-06 DE DE19792913856 patent/DE2913856A1/de not_active Withdrawn
-
1980
- 1980-03-28 ES ES490031A patent/ES8202539A1/es not_active Expired
- 1980-04-01 AT AT80101719T patent/ATE8621T1/de not_active IP Right Cessation
- 1980-04-01 EP EP80101719A patent/EP0019069B1/de not_active Expired
- 1980-04-01 DE DE8080101719T patent/DE3068652D1/de not_active Expired
- 1980-04-03 ZA ZA00802011A patent/ZA802011B/xx unknown
- 1980-04-03 US US06/136,819 patent/US4304783A/en not_active Expired - Lifetime
- 1980-04-03 AU AU57170/80A patent/AU544615B2/en not_active Ceased
- 1980-04-03 CA CA000349229A patent/CA1152505A/en not_active Expired
- 1980-04-03 HU HU80808A patent/HU184735B/hu not_active IP Right Cessation
- 1980-04-04 IL IL59768A patent/IL59768A/xx unknown
- 1980-04-05 JP JP4408380A patent/JPS55141465A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU544615B2 (en) | 1985-06-06 |
EP0019069A2 (de) | 1980-11-26 |
HU184735B (en) | 1984-10-29 |
DE2913856A1 (de) | 1980-10-23 |
IL59768A0 (en) | 1980-06-30 |
ZA802011B (en) | 1981-04-29 |
JPS55141465A (en) | 1980-11-05 |
ATE8621T1 (de) | 1984-08-15 |
AU5717080A (en) | 1980-10-09 |
CA1152505A (en) | 1983-08-23 |
DE3068652D1 (en) | 1984-08-30 |
IL59768A (en) | 1986-01-31 |
ES490031A0 (es) | 1982-02-01 |
EP0019069B1 (de) | 1984-07-25 |
EP0019069A3 (en) | 1981-01-14 |
US4304783A (en) | 1981-12-08 |
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