ES8201134A1 - Procedimiento para preparar derivados de tetrahidrotiopirano(3,2-b)indol - Google Patents

Procedimiento para preparar derivados de tetrahidrotiopirano(3,2-b)indol

Info

Publication number
ES8201134A1
ES8201134A1 ES498968A ES498968A ES8201134A1 ES 8201134 A1 ES8201134 A1 ES 8201134A1 ES 498968 A ES498968 A ES 498968A ES 498968 A ES498968 A ES 498968A ES 8201134 A1 ES8201134 A1 ES 8201134A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
tetrahydrothiopyrano
image
indole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498968A
Other languages
English (en)
Other versions
ES498968A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of ES498968A0 publication Critical patent/ES498968A0/es
Publication of ES8201134A1 publication Critical patent/ES8201134A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA L OBTENCION DE DERIVADOS DE TETRAHIDROTIOPIRANOS (3,2-BINDOL Y SUS SALES FISIOLOGICAMENTE ACEPTABLES, DE FORMULA (I), EN LA QUE R1 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES; R2 Y R4 SON HIDROGENO O ALCOHILO C1-6,Y N VALE 0-2. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1 TIENE EL MISMO SIGNIFICADO QUE EEN LA FORMULA (I), CON AMONIACO O UNA MINA PRIMARIA. LA REACCION DE CONDENSACION SE LLEVA AL CABO EN CONDICIONES REDUCTORAS,O EL PRODUCTO OBTENIDO SE REDUCE POSTERIORMENTE CON UN AGENTE REDUCTOR, TAL COMO BOHIDRURO SODICO, EN UN DISOLVENTE ORGANICO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICS POR SU ACTIVIDAD ANALGESICA,ANTIINFLAMATORIA Y ANTIDEPRESORA.
ES498968A 1980-02-27 1981-01-30 Procedimiento para preparar derivados de tetrahidrotiopirano(3,2-b)indol Expired ES8201134A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2375180A JPS56120686A (en) 1980-02-27 1980-02-27 Tetrahydrothiopyrano 3,2-b indole derivative

Publications (2)

Publication Number Publication Date
ES498968A0 ES498968A0 (es) 1981-12-01
ES8201134A1 true ES8201134A1 (es) 1981-12-01

Family

ID=12119010

Family Applications (2)

Application Number Title Priority Date Filing Date
ES498968A Expired ES8201134A1 (es) 1980-02-27 1981-01-30 Procedimiento para preparar derivados de tetrahidrotiopirano(3,2-b)indol
ES502954A Granted ES502954A0 (es) 1980-02-27 1981-06-11 Procedimiento para preparar derivados de tetrahidrotiopira- no-(3,2-b) indol

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES502954A Granted ES502954A0 (es) 1980-02-27 1981-06-11 Procedimiento para preparar derivados de tetrahidrotiopira- no-(3,2-b) indol

Country Status (8)

Country Link
US (1) US4910318A (es)
EP (1) EP0035259B1 (es)
JP (1) JPS56120686A (es)
AU (1) AU538185B2 (es)
CA (1) CA1158241A (es)
DE (1) DE3162851D1 (es)
DK (1) DK150305C (es)
ES (2) ES8201134A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2639944B1 (fr) * 1988-12-06 1991-01-18 Adir Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU675141B2 (en) * 1993-07-20 1997-01-23 Adir Et Compagnie (Thia)cycloalkyl(b)indoles, process for preparing them and pharmaceutical compositions containing them
FR2720064B1 (fr) * 1994-05-19 1996-06-28 Adir Thiacycloalkyl [b] indoles, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE37060B1 (en) * 1972-01-13 1977-04-27 Ayerst Mckenna & Harrison Indole derivatives
JPS557201A (en) * 1978-05-23 1980-01-19 Shionogi & Co Ltd Derivative of tetrahydrothiopyrano(2,3-b)indole

Also Published As

Publication number Publication date
JPS56120686A (en) 1981-09-22
DE3162851D1 (en) 1984-05-03
JPS6365675B2 (es) 1988-12-16
EP0035259A1 (en) 1981-09-09
AU6793481A (en) 1981-09-03
EP0035259B1 (en) 1984-03-28
AU538185B2 (en) 1984-08-02
DK85481A (da) 1981-08-28
DK150305C (da) 1987-11-23
ES8301994A1 (es) 1982-12-16
ES502954A0 (es) 1982-12-16
ES498968A0 (es) 1981-12-01
US4910318A (en) 1990-03-20
CA1158241A (en) 1983-12-06
DK150305B (da) 1987-02-02

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