ES8200364A1 - Procedimiento para la obtencion de derivados de la fenotia- zina - Google Patents

Procedimiento para la obtencion de derivados de la fenotia- zina

Info

Publication number
ES8200364A1
ES8200364A1 ES491048A ES491048A ES8200364A1 ES 8200364 A1 ES8200364 A1 ES 8200364A1 ES 491048 A ES491048 A ES 491048A ES 491048 A ES491048 A ES 491048A ES 8200364 A1 ES8200364 A1 ES 8200364A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
phenothiazine derivatives
imidazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491048A
Other languages
English (en)
Other versions
ES491048A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES8200364A1 publication Critical patent/ES8200364A1/es
Publication of ES491048A0 publication Critical patent/ES491048A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE FONOTIAZINA. CONSISTE EN HACER REACCIONAR UN DERIVADO DE FENOTIAZINA CON UNA BASE, O BIEN SE HACE REACCIONAR UN DERIVADO DE FENOTIAZINA CON UN ACIDO CARBOXILICO, O BIEN UNA FENOSTIAZINA SE TRANSFORMA POR TRATAMIENTO CON AGENTES OXIDANTES AL SULFOXIDO O A LA SULFONA CORRESPONDIENTE. LAS BASES OBTENIDAD SE PUEDEN TRANSFORMAR MEDIANTE TRATAMIENTO CON UN ACIDO EN UNA SAL DE ADICION DE ACIDO FISOLOGICAMENTE ACEPTABLE. SE OBTIENE EL COMPUESTO DE FORMULA GENERAL (I), EN QUE R ES H, F, CL, I, CH3, CF3, CN, CH30, CH3I, Y SIGNIFICA S, SO O SO2; Z ES 1-IMIDAZOLIL, 2-METIL-1-IMIDAZOLIL, 1-PIRAZOLIL O 1-BENCIMIDAZOLIL.
ES491048A 1979-05-02 1980-04-30 Procedimiento para la obtencion de derivados de la fenotia- zina Granted ES491048A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792917650 DE2917650A1 (de) 1979-05-02 1979-05-02 Phenothiazinderivate und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8200364A1 true ES8200364A1 (es) 1981-11-01
ES491048A0 ES491048A0 (es) 1981-11-01

Family

ID=6069737

Family Applications (1)

Application Number Title Priority Date Filing Date
ES491048A Granted ES491048A0 (es) 1979-05-02 1980-04-30 Procedimiento para la obtencion de derivados de la fenotia- zina

Country Status (19)

Country Link
US (1) US4289768A (es)
EP (1) EP0018542B1 (es)
JP (1) JPS55147280A (es)
AR (1) AR227640A1 (es)
AT (1) ATE2673T1 (es)
AU (1) AU533392B2 (es)
CA (1) CA1135263A (es)
CS (1) CS222690B2 (es)
DD (1) DD151063A5 (es)
DE (2) DE2917650A1 (es)
ES (1) ES491048A0 (es)
FI (1) FI801397A (es)
HU (1) HU181702B (es)
IE (1) IE50177B1 (es)
IL (1) IL59972A (es)
NO (1) NO801255L (es)
PL (1) PL122711B2 (es)
SU (1) SU867309A3 (es)
ZA (1) ZA802629B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112358475B (zh) * 2020-11-30 2022-09-06 西北师范大学 一种苯并吡喃鎓-吩噻嗪衍生物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2591679A (en) * 1952-04-08 Aminoalkanoyl phenothiazine deriv
FR1488281A (fr) * 1966-03-29 1967-07-13 Chimetron Sarl Benzimidazoles portant un substituant dérivé de la phénothiazine

Also Published As

Publication number Publication date
PL223898A2 (es) 1981-02-13
FI801397A (fi) 1980-11-03
DD151063A5 (de) 1981-09-30
IL59972A0 (en) 1980-07-31
DE2917650A1 (de) 1980-11-13
ATE2673T1 (de) 1986-03-15
HU181702B (en) 1983-11-28
CS222690B2 (en) 1983-07-29
IL59972A (en) 1983-10-31
AU5797280A (en) 1980-11-06
AU533392B2 (en) 1983-11-24
JPS55147280A (en) 1980-11-17
AR227640A1 (es) 1982-11-30
EP0018542B1 (de) 1983-03-02
NO801255L (no) 1980-11-03
EP0018542A1 (de) 1980-11-12
IE50177B1 (en) 1986-03-05
ES491048A0 (es) 1981-11-01
PL122711B2 (en) 1982-08-31
SU867309A3 (ru) 1981-09-23
US4289768A (en) 1981-09-15
IE800886L (en) 1980-11-02
DE3062170D1 (en) 1983-04-07
CA1135263A (en) 1982-11-09
ZA802629B (en) 1981-05-27

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