ES8107198A1 - Un procedimiento para la preparacion de nuevos 1,2,4-triazo-les - Google Patents

Un procedimiento para la preparacion de nuevos 1,2,4-triazo-les

Info

Publication number
ES8107198A1
ES8107198A1 ES496486A ES496486A ES8107198A1 ES 8107198 A1 ES8107198 A1 ES 8107198A1 ES 496486 A ES496486 A ES 496486A ES 496486 A ES496486 A ES 496486A ES 8107198 A1 ES8107198 A1 ES 8107198A1
Authority
ES
Spain
Prior art keywords
ring
alkyl
incorporation
cycloalkyl
rest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496486A
Other languages
English (en)
Other versions
ES496486A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES496486A0 publication Critical patent/ES496486A0/es
Publication of ES8107198A1 publication Critical patent/ES8107198A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 1,2,4-TRIAZOLES DE FORMULA (I), DE SUS SALES, HIDRATOS Y BIOPRECURSORES FISIOLOGICAMENTE COMPATIBLES, EN LA QUE R1, R2, R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES; ALQ ES UNA CADENA ALQUILENICA C1-4; Q ES UN ANILLO DE FURANO, TIOFENO O BENCENICO, SUSTITUIDOS; X ES -CH2-,-O- O -S-; M VALE 2-4, Y N VALE 0-2. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN AGENTE NUCLEOFILO, FORMULA EN LA QUE L ELEVADO A A ES R1R2N Y L ELEVADO A B ES (CH2)QL ELEVADO A C, O BIEN L ELEVADO A A ES L ELEVADO A D Y L ELEVADO A B ES R4, SIENDO L ELEVADO A C Y L ELEVADO A D GRUPOS SALIENTES, Y Q VALE DE 1 A 6. EL AGENTE NUCLEOFILO PUEDE TENER PROTECCION DE CUALQUIER GRUPO REACTIVO. TAMBIEN SE PUEDE TRANSFORMAR UN RADICAL R4 EN OTRO RADICAL R4, ASI COMO OBTENER LAS SALES CORRESPONDIENTES POR METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES MEDICAS POR SU ACTIVIDAD DE BLOQUEO DE LA HISTAMINA H2. *FORMULA*
ES496486A 1979-03-02 1980-10-31 Un procedimiento para la preparacion de nuevos 1,2,4-triazo-les Expired ES8107198A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7907421 1979-03-02
GB7907423 1979-03-02

Publications (2)

Publication Number Publication Date
ES496486A0 ES496486A0 (es) 1981-10-01
ES8107198A1 true ES8107198A1 (es) 1981-10-01

Family

ID=26270755

Family Applications (5)

Application Number Title Priority Date Filing Date
ES489127A Expired ES8105721A1 (es) 1979-03-02 1980-03-01 Un procedimiento para la preparacion de nuevos 1, 2, 4-tria-zoles.
ES496485A Expired ES8203857A1 (es) 1979-03-02 1980-10-31 Un procedimiento para la preparacion de nuevos 1,2,4-triazo-les
ES496484A Expired ES8107199A1 (es) 1979-03-02 1980-10-31 Un procedimiento para la preparacion de nuevos 1,2,4-triazo-les
ES496487A Granted ES496487A0 (es) 1979-03-02 1980-10-31 Un procedimiento para la preparacion de nuevos derivados hi-droxialquil-triazoles
ES496486A Expired ES8107198A1 (es) 1979-03-02 1980-10-31 Un procedimiento para la preparacion de nuevos 1,2,4-triazo-les

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES489127A Expired ES8105721A1 (es) 1979-03-02 1980-03-01 Un procedimiento para la preparacion de nuevos 1, 2, 4-tria-zoles.
ES496485A Expired ES8203857A1 (es) 1979-03-02 1980-10-31 Un procedimiento para la preparacion de nuevos 1,2,4-triazo-les
ES496484A Expired ES8107199A1 (es) 1979-03-02 1980-10-31 Un procedimiento para la preparacion de nuevos 1,2,4-triazo-les
ES496487A Granted ES496487A0 (es) 1979-03-02 1980-10-31 Un procedimiento para la preparacion de nuevos derivados hi-droxialquil-triazoles

Country Status (15)

Country Link
EP (1) EP0016565B1 (es)
KR (2) KR850001319B1 (es)
AU (1) AU535701B2 (es)
CA (1) CA1159453A (es)
DE (1) DE3067920D1 (es)
DK (1) DK89480A (es)
ES (5) ES8105721A1 (es)
FI (1) FI68395C (es)
GB (1) GB2047238B (es)
IE (1) IE49528B1 (es)
IL (1) IL59503A (es)
NO (1) NO800583L (es)
NZ (1) NZ193009A (es)
PT (1) PT70884A (es)
YU (4) YU56680A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028483B1 (en) * 1979-10-22 1984-04-18 Glaxo Group Limited 1,2,4-triazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
CH655104A5 (fr) * 1980-02-28 1986-03-27 Glaxo Group Ltd Derives heterocycliques triazoliques, procedes pour leur preparation et compositions pharmaceutiques les comportant.
DK381581A (da) * 1980-08-27 1982-02-28 Glaxo Group Ltd Fremgangsmaade til fremstilling af heterocycliske derivater
JPS5775976A (en) * 1980-08-27 1982-05-12 Glaxo Group Ltd Novel heterocyclic derivative, manufacture and medicinal composition containing same
US4439437A (en) * 1981-04-28 1984-03-27 Smith Kline & French Laboratories Limited 2-[2-Thiazolyl or 2-guanidino-4-thiazolyl methylthioethyl(or butyl)amino]-3-(hydroxy or carboxy)pyridines, compositions containing same and method of use
AU8480982A (en) * 1981-06-11 1983-01-13 Glaxo Group Limited 1,2,4-triazole derivatives with histamine h2-blocking activity
EP0070743A3 (en) * 1981-07-22 1983-10-12 Glaxo Group Limited Pharmaceutical compositions containing compounds having action on histamine receptors
BE894286A (fr) * 1981-09-04 1983-03-02 Glaxo Group Ltd Composition pharmaceutique contenant un medicament anti-inflammatoire systemique non steroidique et du 1-methyl-5-((3-(3-(1-piperidinylmethyl)phenoxy)-propyl)amino -1h-1,2,4-triazole-3-methanol ou un sel de ce compose
ES520031A0 (es) * 1982-02-24 1984-04-01 Glaxo Group Ltd Un procedimiento para prepararacion de derivados del triazol.
GB9009437D0 (en) * 1990-04-26 1990-06-20 Glaxo Group Ltd Chemical compounds
TWI697485B (zh) * 2015-07-21 2020-07-01 日商捷恩智股份有限公司 含唑啉環的化合物、含有其的電子輸送/注入層用材料、使用其的有機電致發光元件、顯示裝置及照明裝置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681374A (en) * 1970-08-11 1972-08-01 Asahi Chemical Ind Synthetic nacreous triazole crystals and method for production thereof
GB1403866A (en) * 1971-12-06 1975-08-28 Wyeth John & Brother Ltd Derivatives of 3-amino-1,2,4-triazoles
US4104381A (en) * 1973-05-03 1978-08-01 Smith Kline & French Laboratories Limited Pharmacologically active compounds
US4076938A (en) * 1974-08-29 1978-02-28 Ciba-Geigy Corporation Process for the production of 3-hydroxy-1,2,4-triazole derivatives
GB1547564A (en) * 1975-06-05 1979-06-20 Lilly Industries Ltd Acylated amino-heteroaryl compounds
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
IE46886B1 (en) * 1977-05-17 1983-10-19 Allen & Hanburys Ltd Aminoalkyl-benzene derivatives
GB1601459A (en) * 1977-05-17 1981-10-28 Allen & Hanburys Ltd Aminoalkyl thiophene derivatives
AR228941A1 (es) * 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos

Also Published As

Publication number Publication date
ES496486A0 (es) 1981-10-01
NZ193009A (en) 1983-07-15
ES496485A0 (es) 1982-04-01
KR850001318B1 (ko) 1985-09-14
IL59503A0 (en) 1980-05-30
NO800583L (no) 1980-09-03
ES489127A0 (es) 1981-05-16
DE3067920D1 (en) 1984-06-28
EP0016565A1 (en) 1980-10-01
ES8107200A1 (es) 1981-10-01
KR850001319B1 (en) 1985-09-14
PT70884A (en) 1980-03-01
GB2047238B (en) 1983-09-14
KR830001911A (ko) 1983-05-19
FI800628A (fi) 1980-09-03
CA1159453A (en) 1983-12-27
ES496487A0 (es) 1981-10-01
FI68395C (fi) 1985-09-10
YU277482A (en) 1983-04-30
ES8105721A1 (es) 1981-05-16
DK89480A (da) 1980-09-03
YU277682A (en) 1983-04-30
KR850003289A (ko) 1985-06-13
AU535701B2 (en) 1984-04-05
ES8203857A1 (es) 1982-04-01
FI68395B (fi) 1985-05-31
YU56680A (en) 1983-04-30
IE800410L (en) 1980-09-02
ES496484A0 (es) 1981-10-01
GB2047238A (en) 1980-11-26
ES8107199A1 (es) 1981-10-01
IE49528B1 (en) 1985-10-16
IL59503A (en) 1985-03-31
EP0016565B1 (en) 1984-05-23
AU5604080A (en) 1980-09-04
YU277782A (en) 1983-04-30

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