ES8106088A1 - Procedimiento cromatografico para la separacion de impurezasde un antibiotico aminoglucosido - Google Patents

Procedimiento cromatografico para la separacion de impurezasde un antibiotico aminoglucosido

Info

Publication number
ES8106088A1
ES8106088A1 ES493829A ES493829A ES8106088A1 ES 8106088 A1 ES8106088 A1 ES 8106088A1 ES 493829 A ES493829 A ES 493829A ES 493829 A ES493829 A ES 493829A ES 8106088 A1 ES8106088 A1 ES 8106088A1
Authority
ES
Spain
Prior art keywords
chromatographic process
gentamicin
impurities
separation
recovery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493829A
Other languages
English (en)
Other versions
ES493829A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ES8106088A1 publication Critical patent/ES8106088A1/es
Publication of ES493829A0 publication Critical patent/ES493829A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO CROMATOGRAFICO PARA LA SEPARACION DE IMPUREZAS DE UN ANIBIOTICO AMINOGLUCOSIDO. SE AJUSTA EL PH DE UNA SOLUCION DE ANTIBIOTICO AMINOGLUCOSIDO, QUE ES UN COMPLEJO DE GENTAMICINA, ALREDEDOR DE 3 A 11; SE PASA LA SOLUCION DE PH AJUSTADO POR UNA RESINA DE INTERCAMBIO IONICO QUE HA SIDO CALENTADA ENTRE 25 Y 100 GC; SE PASA AGUA A UNA TEMPERATURA DE 25 A 100 GC, POR UNA COLUMNA CROMATOGRAFICA; POR ULTIMO SE RECOGEN LAS FRACCIONES RICAS EN ANTIBIOTICO AMINOGLUCOSIDO, QUE A LA VEZ SON FRACCIONES RICAS EN GENTAMICINA.
ES493829A 1979-07-30 1980-07-30 Procedimiento cromatografico para la separacion de impurezasde un antibiotico aminoglucosido Granted ES493829A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/061,682 US4252971A (en) 1979-07-30 1979-07-30 Chromatographic process

Publications (2)

Publication Number Publication Date
ES8106088A1 true ES8106088A1 (es) 1981-08-01
ES493829A0 ES493829A0 (es) 1981-08-01

Family

ID=22037419

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493829A Granted ES493829A0 (es) 1979-07-30 1980-07-30 Procedimiento cromatografico para la separacion de impurezasde un antibiotico aminoglucosido

Country Status (8)

Country Link
US (1) US4252971A (es)
JP (1) JPS5621597A (es)
DE (1) DE3024780A1 (es)
ES (1) ES493829A0 (es)
FR (1) FR2462442A1 (es)
GB (1) GB2054577B (es)
IT (1) IT1128164B (es)
NL (1) NL8004013A (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5220040A (en) * 1975-08-07 1977-02-15 Matsushita Electric Ind Co Ltd Theremal printing head
US5188945A (en) * 1991-09-09 1993-02-23 American Cyanamid Company Recovery process for antibiotics ll-e19020 alpha and beta
WO2004105688A2 (en) * 2003-05-21 2004-12-09 Advanced Research And Technology Institute, Inc. Bactericidal composition and associated method
CN102617666A (zh) * 2012-03-07 2012-08-01 广州牌牌生物科技有限公司 一种使硫酸庆大霉素中西索米星和小诺霉素含量符合2010版中国药典标准的工艺方法
CN102633848B (zh) * 2012-04-09 2014-07-02 南阳普康药业有限公司 一种庆大霉素除杂方法
CN103374047B (zh) * 2012-04-27 2016-05-11 无锡济民可信山禾药业股份有限公司 一种高纯度的3，2″，6″-三-N-乙酰基庆大C1a碱(P1)分离纯化方法
CN105524128B (zh) * 2015-12-25 2018-08-31 无锡济民可信山禾药业股份有限公司 一种庆大霉素C1a的连续色谱分离工艺
CN109096347B (zh) * 2018-09-20 2022-03-08 无锡济煜山禾药业股份有限公司 一种高纯度的3,2`,6`-三-N-乙酰基庆大C1a碱（P1）纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1269572A (fr) * 1959-06-08 1961-08-18 Bristol Lab Internat S A Procédé de décoloration de la kanamycine
US3091572A (en) * 1962-07-16 1963-05-28 Schering Corp Gentamycin and method of production
CH551965A (de) * 1970-06-22 1974-07-31 Scherico Ltd Verfahren zur herstellung antibiotisch wirksamer verbindungen.
US4011391A (en) * 1971-04-20 1977-03-08 Takeda Chemical Industries, Ltd. Validamycin c, d, e and f antibiotics
US4045610A (en) * 1973-10-24 1977-08-30 Abbott Laboratories Antibiotics designated xk-88 series
US4011390A (en) * 1974-02-15 1977-03-08 Schering-Plough Corporation Semi-synthetic aminocyclitol aminoglycoside antibiotics and methods for the preparation thereof

Also Published As

Publication number Publication date
JPS5621597A (en) 1981-02-28
GB2054577A (en) 1981-02-18
FR2462442A1 (fr) 1981-02-13
FR2462442B1 (es) 1983-04-29
NL8004013A (nl) 1981-02-03
IT8049293A0 (it) 1980-07-21
IT1128164B (it) 1986-05-28
DE3024780A1 (de) 1981-02-19
ES493829A0 (es) 1981-08-01
GB2054577B (en) 1983-03-16
US4252971A (en) 1981-02-24

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